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PubMed code 26985320

Compile data set for download or QSAR
Found 89 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@H](CCCC(O)=O)O2 |r|
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 4.60E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169607
PNG
(CHEMBL3805316)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(C)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H23NO5S/c1-11-2-4-12(5-3-11)25-9-14-13-6-7-17(26-18(13)8-16(14)22)19-21-15(10-27-19)20(23)24/h2-5,10,13-14,16-18,22H,6-9H2,1H3,(H,23,24)/t13-,14-,16-,17-,18+/m1/s1
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n/an/an/an/a 27n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 250n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169609
PNG
(CHEMBL3805981)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(OC(F)(F)F)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO6S/c21-20(22,23)30-11-3-1-2-10(6-11)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-31-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 69n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 0.800n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 33n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50360629
PNG
(CHEMBL1933725)
Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H22N2O4S2/c23-16(12-14-4-2-1-3-5-14)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h1-6,8,13,15-16,23H,7,9-12H2,(H,25,26)/b8-6+/t15-,16+/m0/s1
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n/an/an/an/a 5.60n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169610
PNG
(CHEMBL3805596)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(Cl)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20ClNO5S/c20-10-2-1-3-11(6-10)25-8-13-12-4-5-16(26-17(12)7-15(13)22)18-21-14(9-27-18)19(23)24/h1-3,6,9,12-13,15-17,22H,4-5,7-8H2,(H,23,24)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 97n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a 4.20E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50360629
PNG
(CHEMBL1933725)
Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H22N2O4S2/c23-16(12-14-4-2-1-3-5-14)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h1-6,8,13,15-16,23H,7,9-12H2,(H,25,26)/b8-6+/t15-,16+/m0/s1
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n/an/an/an/a 0.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50156543
PNG
(CHEMBL3793045)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(c3)C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)10-2-1-3-11(6-10)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-30-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169612
PNG
(CHEMBL3806060)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20FNO5S/c20-12-3-1-2-4-15(12)25-8-11-10-5-6-16(26-17(10)7-14(11)22)18-21-13(9-27-18)19(23)24/h1-4,9-11,14,16-17,22H,5-8H2,(H,23,24)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 23n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169613
PNG
(CHEMBL3806284)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)12-3-1-2-4-15(12)28-8-11-10-5-6-16(29-17(10)7-14(11)25)18-24-13(9-30-18)19(26)27/h1-4,9-11,14,16-17,25H,5-8H2,(H,26,27)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 0.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169608
PNG
(CHEMBL3806076)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(F)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20FNO5S/c20-10-2-1-3-11(6-10)25-8-13-12-4-5-16(26-17(12)7-15(13)22)18-21-14(9-27-18)19(23)24/h1-3,6,9,12-13,15-17,22H,4-5,7-8H2,(H,23,24)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169607
PNG
(CHEMBL3805316)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(C)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H23NO5S/c1-11-2-4-12(5-3-11)25-9-14-13-6-7-17(26-18(13)8-16(14)22)19-21-15(10-27-19)20(23)24/h2-5,10,13-14,16-18,22H,6-9H2,1H3,(H,23,24)/t13-,14-,16-,17-,18+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169554
PNG
(CHEMBL3805408)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(cc3)C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)10-1-3-11(4-2-10)28-8-13-12-5-6-16(29-17(12)7-15(13)25)18-24-14(9-30-18)19(26)27/h1-4,9,12-13,15-17,25H,5-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169553
PNG
(CHEMBL3805075)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(F)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C22H22N6O3/c23-21-24-17(14-19-25-20(26-28(19)21)18-5-2-10-29-18)15-3-1-4-16(13-15)27-8-6-22(7-9-27)30-11-12-31-22/h1-5,10,13-14H,6-9,11-12H2,(H2,23,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
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Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169615
PNG
(CHEMBL3805455)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H29NO5S/c25-19-13-21-17(10-11-20(29-21)22-24-18(14-30-22)23(26)27)16(19)9-5-2-6-12-28-15-7-3-1-4-8-15/h1,3-4,7-8,14,16-17,19-21,25H,2,5-6,9-13H2,(H,26,27)/t16-,17-,19-,20-,21+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169613
PNG
(CHEMBL3806284)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)12-3-1-2-4-15(12)28-8-11-10-5-6-16(29-17(10)7-14(11)25)18-24-13(9-30-18)19(26)27/h1-4,9-11,14,16-17,25H,5-8H2,(H,26,27)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 11n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@H](CCCC(O)=O)O2 |r|
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 47n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169606
PNG
(CHEMBL3805122)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(OC(F)(F)F)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO6S/c21-20(22,23)30-11-3-1-10(2-4-11)28-8-13-12-5-6-16(29-17(12)7-15(13)25)18-24-14(9-31-18)19(26)27/h1-4,9,12-13,15-17,25H,5-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 14n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169615
PNG
(CHEMBL3805455)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H29NO5S/c25-19-13-21-17(10-11-20(29-21)22-24-18(14-30-22)23(26)27)16(19)9-5-2-6-12-28-15-7-3-1-4-8-15/h1,3-4,7-8,14,16-17,19-21,25H,2,5-6,9-13H2,(H,26,27)/t16-,17-,19-,20-,21+/m1/s1
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n/an/an/an/a 28n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169611
PNG
(CHEMBL3805554)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(C)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H23NO5S/c1-11-3-2-4-12(7-11)25-9-14-13-5-6-17(26-18(13)8-16(14)22)19-21-15(10-27-19)20(23)24/h2-4,7,10,13-14,16-18,22H,5-6,8-9H2,1H3,(H,23,24)/t13-,14-,16-,17-,18+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50156543
PNG
(CHEMBL3793045)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(c3)C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)10-2-1-3-11(6-10)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-30-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 9n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a 5.80E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a 700n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169609
PNG
(CHEMBL3805981)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(OC(F)(F)F)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO6S/c21-20(22,23)30-11-3-1-2-10(6-11)28-8-13-12-4-5-16(29-17(12)7-15(13)25)18-24-14(9-31-18)19(26)27/h1-3,6,9,12-13,15-17,25H,4-5,7-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169611
PNG
(CHEMBL3805554)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(C)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H23NO5S/c1-11-3-2-4-12(7-11)25-9-14-13-5-6-17(26-18(13)8-16(14)22)19-21-15(10-27-19)20(23)24/h2-4,7,10,13-14,16-18,22H,5-6,8-9H2,1H3,(H,23,24)/t13-,14-,16-,17-,18+/m1/s1
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n/an/an/an/a 3.60n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169614
PNG
(CHEMBL3805767)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3Cl)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20ClNO5S/c20-12-3-1-2-4-15(12)25-8-11-10-5-6-16(26-17(10)7-14(11)22)18-21-13(9-27-18)19(23)24/h1-4,9-11,14,16-17,22H,5-8H2,(H,23,24)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 3.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@H](CCCC(O)=O)O2 |r|
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 8.90E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a 7.60E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 360n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 260n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))		BDBM50360629
PNG
(CHEMBL1933725)
Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H22N2O4S2/c23-16(12-14-4-2-1-3-5-14)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h1-6,8,13,15-16,23H,7,9-12H2,(H,25,26)/b8-6+/t15-,16+/m0/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 1.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169614
PNG
(CHEMBL3805767)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3Cl)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20ClNO5S/c20-12-3-1-2-4-15(12)25-8-11-10-5-6-16(26-17(10)7-14(11)22)18-21-13(9-27-18)19(23)24/h1-4,9-11,14,16-17,22H,5-8H2,(H,23,24)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a 203n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 1.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 13n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 380n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 970n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 347n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169553
PNG
(CHEMBL3805075)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(F)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C22H22N6O3/c23-21-24-17(14-19-25-20(26-28(19)21)18-5-2-10-29-18)15-3-1-4-16(13-15)27-8-6-22(7-9-27)30-11-12-31-22/h1-5,10,13-14H,6-9,11-12H2,(H2,23,24)
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n/an/an/an/a 7n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169554
PNG
(CHEMBL3805408)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(cc3)C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO5S/c21-20(22,23)10-1-3-11(4-2-10)28-8-13-12-5-6-16(29-17(12)7-15(13)25)18-24-14(9-30-18)19(26)27/h1-4,9,12-13,15-17,25H,5-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 1.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a 10n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169606
PNG
(CHEMBL3805122)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(OC(F)(F)F)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C20H20F3NO6S/c21-20(22,23)30-11-3-1-10(2-4-11)28-8-13-12-5-6-16(29-17(12)7-15(13)25)18-24-14(9-31-18)19(26)27/h1-4,9,12-13,15-17,25H,5-8H2,(H,26,27)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 4.50E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 32n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 346n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 7.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 11n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50156542
PNG
(CHEMBL3793786)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(Cl)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20ClNO5S/c20-10-1-3-11(4-2-10)25-8-13-12-5-6-16(26-17(12)7-15(13)22)18-21-14(9-27-18)19(23)24/h1-4,9,12-13,15-17,22H,5-8H2,(H,23,24)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169608
PNG
(CHEMBL3806076)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(F)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20FNO5S/c20-10-2-1-3-11(6-10)25-8-13-12-4-5-16(26-17(12)7-15(13)22)18-21-14(9-27-18)19(23)24/h1-3,6,9,12-13,15-17,22H,4-5,7-8H2,(H,23,24)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 5.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169610
PNG
(CHEMBL3805596)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3cccc(Cl)c3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20ClNO5S/c20-10-2-1-3-11(6-10)25-8-13-12-4-5-16(26-17(12)7-15(13)22)18-21-14(9-27-18)19(23)24/h1-3,6,9,12-13,15-17,22H,4-5,7-8H2,(H,23,24)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 6.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a 3.80n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 7.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES [H][C@]12C[C@@H](O)[C@H](CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50169612
PNG
(CHEMBL3806060)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20FNO5S/c20-12-3-1-2-4-15(12)25-8-11-10-5-6-16(26-17(10)7-14(11)22)18-21-13(9-27-18)19(23)24/h1-4,9-11,14,16-17,22H,5-8H2,(H,23,24)/t10-,11-,14-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM50156542
PNG
(CHEMBL3793786)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccc(Cl)cc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H20ClNO5S/c20-10-1-3-11(4-2-10)25-8-13-12-5-6-16(26-17(12)7-15(13)22)18-21-14(9-27-18)19(23)24/h1-4,9,12-13,15-17,22H,5-8H2,(H,23,24)/t12-,13-,15-,16-,17+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated fo...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))		BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 8.50E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analys...

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES [H][C@]12C[C@@H](O)[C@H](COc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/m1/s1
KEGG

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PC cid
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UniChem

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))		BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\CCOc3ccccc3)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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Article
PubMed
n/an/an/an/a 160n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis

ACS Med Chem Lett 7: 306-11 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00455
BindingDB Entry DOI: 10.7270/Q2125VKG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%