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PubMed code 27777004

Compile data set for download or QSAR
Found 90 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM175970
PNG
(US10047103, 3 | US9605024, Example 3 | US9688695, ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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n/an/a 0.00400n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 (unknown origin) assessed as inhibition of activating peptide-induced receptor activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM175970
PNG
(US10047103, 3 | US9605024, Example 3 | US9688695, ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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n/an/a 0.0230n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 (unknown origin) assessed as inhibition of gamma-thrombin-induced receptor activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199438
PNG
(CHEMBL3931873)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O2S/c1-17-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 (unknown origin) assessed as inhibition of activating peptide-induced receptor activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199421
PNG
(CHEMBL3906197)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-2-4-8(5-3-7)12(13,14)15/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199421
PNG
(CHEMBL3906197)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-2-4-8(5-3-7)12(13,14)15/h2-6H,1H3
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n/an/a 15n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199421
PNG
(CHEMBL3906197)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-2-4-8(5-3-7)12(13,14)15/h2-6H,1H3
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n/an/a 16n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a 21n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199416
PNG
(CHEMBL3936444)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H8F3N3O2S/c1-19-11-17-18-6-9(16-10(18)21-11)7-2-4-8(5-3-7)20-12(13,14)15/h2-6H,1H3
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n/an/a 27n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199416
PNG
(CHEMBL3936444)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H8F3N3O2S/c1-19-11-17-18-6-9(16-10(18)21-11)7-2-4-8(5-3-7)20-12(13,14)15/h2-6H,1H3
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n/an/a 27n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199440
PNG
(CHEMBL3909608)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H7Cl2N3OS/c1-17-11-15-16-5-9(14-10(16)18-11)6-2-3-7(12)8(13)4-6/h2-5H,1H3
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n/an/a 28n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199416
PNG
(CHEMBL3936444)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H8F3N3O2S/c1-19-11-17-18-6-9(16-10(18)21-11)7-2-4-8(5-3-7)20-12(13,14)15/h2-6H,1H3
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n/an/a 28n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199440
PNG
(CHEMBL3909608)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H7Cl2N3OS/c1-17-11-15-16-5-9(14-10(16)18-11)6-2-3-7(12)8(13)4-6/h2-5H,1H3
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n/an/a 29n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199425
PNG
(CHEMBL3950308)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-3-2-4-8(5-7)12(13,14)15/h2-6H,1H3
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n/an/a 36n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199425
PNG
(CHEMBL3950308)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-3-2-4-8(5-7)12(13,14)15/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199423
PNG
(CHEMBL3983476)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199423
PNG
(CHEMBL3983476)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199431
PNG
(CHEMBL3927486)
Show SMILES COc1nn2cc(nc2s1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H7F6N3OS/c1-23-11-21-22-5-9(20-10(22)24-11)6-2-7(12(14,15)16)4-8(3-6)13(17,18)19/h2-5H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199431
PNG
(CHEMBL3927486)
Show SMILES COc1nn2cc(nc2s1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H7F6N3OS/c1-23-11-21-22-5-9(20-10(22)24-11)6-2-7(12(14,15)16)4-8(3-6)13(17,18)19/h2-5H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199442
PNG
(CHEMBL3922644)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(C)cc1
Show InChI InChI=1S/C12H11N3OS/c1-8-3-5-9(6-4-8)10-7-15-11(13-10)17-12(14-15)16-2/h3-7H,1-2H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199442
PNG
(CHEMBL3922644)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(C)cc1
Show InChI InChI=1S/C12H11N3OS/c1-8-3-5-9(6-4-8)10-7-15-11(13-10)17-12(14-15)16-2/h3-7H,1-2H3
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n/an/a 58n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199438
PNG
(CHEMBL3931873)
Show SMILES COc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3O2S/c1-17-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)18-11/h2-7H,1H3
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n/an/a 59n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 (unknown origin) assessed as inhibition of gamma-thrombin-induced receptor activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199433
PNG
(CHEMBL3902806)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C12H7F4N3OS/c1-20-11-18-19-5-9(17-10(19)21-11)6-2-3-8(13)7(4-6)12(14,15)16/h2-5H,1H3
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n/an/a 69n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199433
PNG
(CHEMBL3902806)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C12H7F4N3OS/c1-20-11-18-19-5-9(17-10(19)21-11)6-2-3-8(13)7(4-6)12(14,15)16/h2-5H,1H3
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n/an/a 69n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199428
PNG
(CHEMBL3890362)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(Cl)c1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-3-2-4-8(12)5-7/h2-6H,1H3
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n/an/a 72n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199428
PNG
(CHEMBL3890362)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(Cl)c1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-3-2-4-8(12)5-7/h2-6H,1H3
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n/an/a 73n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199418
PNG
(CHEMBL3973767)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C12H9F2N3O2S/c1-18-12-16-17-6-9(15-11(17)20-12)7-2-4-8(5-3-7)19-10(13)14/h2-6,10H,1H3
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n/an/a 83n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199418
PNG
(CHEMBL3973767)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C12H9F2N3O2S/c1-18-12-16-17-6-9(15-11(17)20-12)7-2-4-8(5-3-7)19-10(13)14/h2-6,10H,1H3
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n/an/a 83n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199437
PNG
(CHEMBL3912611)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)cc1F
Show InChI InChI=1S/C11H7F2N3OS/c1-17-11-15-16-5-9(14-10(16)18-11)7-3-2-6(12)4-8(7)13/h2-5H,1H3
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n/an/a 174n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199437
PNG
(CHEMBL3912611)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)cc1F
Show InChI InChI=1S/C11H7F2N3OS/c1-17-11-15-16-5-9(14-10(16)18-11)7-3-2-6(12)4-8(7)13/h2-5H,1H3
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n/an/a 175n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199427
PNG
(CHEMBL3937549)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C11H8N4O3S/c1-18-11-13-14-6-9(12-10(14)19-11)7-2-4-8(5-3-7)15(16)17/h2-6H,1H3
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n/an/a 207n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199427
PNG
(CHEMBL3937549)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C11H8N4O3S/c1-18-11-13-14-6-9(12-10(14)19-11)7-2-4-8(5-3-7)15(16)17/h2-6H,1H3
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n/an/a 209n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199416
PNG
(CHEMBL3936444)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H8F3N3O2S/c1-19-11-17-18-6-9(16-10(18)21-11)7-2-4-8(5-3-7)20-12(13,14)15/h2-6H,1H3
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n/an/a 229n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199416
PNG
(CHEMBL3936444)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H8F3N3O2S/c1-19-11-17-18-6-9(16-10(18)21-11)7-2-4-8(5-3-7)20-12(13,14)15/h2-6H,1H3
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n/an/a 246n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199423
PNG
(CHEMBL3983476)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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n/an/a 286n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199421
PNG
(CHEMBL3906197)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-2-4-8(5-3-7)12(13,14)15/h2-6H,1H3
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n/an/a 347n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199421
PNG
(CHEMBL3906197)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-2-4-8(5-3-7)12(13,14)15/h2-6H,1H3
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n/an/a 348n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199416
PNG
(CHEMBL3936444)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C12H8F3N3O2S/c1-19-11-17-18-6-9(16-10(18)21-11)7-2-4-8(5-3-7)20-12(13,14)15/h2-6H,1H3
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n/an/a 352n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199421
PNG
(CHEMBL3906197)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-2-4-8(5-3-7)12(13,14)15/h2-6H,1H3
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n/an/a 398n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199424
PNG
(CHEMBL3946410)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C11H8FN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199424
PNG
(CHEMBL3946410)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C11H8FN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199435
PNG
(CHEMBL3894648)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1Cl
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-4-2-3-5-8(7)12/h2-6H,1H3
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199435
PNG
(CHEMBL3894648)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1Cl
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-4-2-3-5-8(7)12/h2-6H,1H3
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n/an/a 437n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199439
PNG
(CHEMBL3955095)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1F
Show InChI InChI=1S/C11H8FN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-4-2-3-5-8(7)12/h2-6H,1H3
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n/an/a 525n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199439
PNG
(CHEMBL3955095)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1F
Show InChI InChI=1S/C11H8FN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-4-2-3-5-8(7)12/h2-6H,1H3
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n/an/a 526n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199432
PNG
(CHEMBL3903596)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC)cc1
Show InChI InChI=1S/C12H11N3O2S/c1-16-9-5-3-8(4-6-9)10-7-15-11(13-10)18-12(14-15)17-2/h3-7H,1-2H3
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n/an/a 589n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199432
PNG
(CHEMBL3903596)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC)cc1
Show InChI InChI=1S/C12H11N3O2S/c1-16-9-5-3-8(4-6-9)10-7-15-11(13-10)18-12(14-15)17-2/h3-7H,1-2H3
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n/an/a 592n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199423
PNG
(CHEMBL3983476)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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n/an/a 617n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199423
PNG
(CHEMBL3983476)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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n/an/a 621n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199423
PNG
(CHEMBL3983476)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-2-4-8(12)5-3-7/h2-6H,1H3
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n/an/a 621n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199414
PNG
(CHEMBL3968857)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(F)c1
Show InChI InChI=1S/C11H8FN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-3-2-4-8(12)5-7/h2-6H,1H3
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n/an/a 675n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199414
PNG
(CHEMBL3968857)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(F)c1
Show InChI InChI=1S/C11H8FN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-3-2-4-8(12)5-7/h2-6H,1H3
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n/an/a 676n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199436
PNG
(CHEMBL3947023)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1
Show InChI InChI=1S/C11H9N3OS/c1-15-11-13-14-7-9(12-10(14)16-11)8-5-3-2-4-6-8/h2-7H,1H3
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n/an/a 757n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199436
PNG
(CHEMBL3947023)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1
Show InChI InChI=1S/C11H9N3OS/c1-15-11-13-14-7-9(12-10(14)16-11)8-5-3-2-4-6-8/h2-7H,1H3
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n/an/a 759n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199434
PNG
(CHEMBL3975497)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C12H8N4OS/c1-17-12-15-16-7-10(14-11(16)18-12)9-4-2-8(6-13)3-5-9/h2-5,7H,1H3
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n/an/a 933n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199434
PNG
(CHEMBL3975497)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C12H8N4OS/c1-17-12-15-16-7-10(14-11(16)18-12)9-4-2-8(6-13)3-5-9/h2-5,7H,1H3
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n/an/a 937n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a 977n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199433
PNG
(CHEMBL3902806)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C12H7F4N3OS/c1-20-11-18-19-5-9(17-10(19)21-11)6-2-3-8(13)7(4-6)12(14,15)16/h2-5H,1H3
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n/an/a 1.09E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199433
PNG
(CHEMBL3902806)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C12H7F4N3OS/c1-20-11-18-19-5-9(17-10(19)21-11)6-2-3-8(13)7(4-6)12(14,15)16/h2-5H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199441
PNG
(CHEMBL3948984)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C12H11N3O3S2/c1-18-12-14-15-7-10(13-11(15)19-12)8-3-5-9(6-4-8)20(2,16)17/h3-7H,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199441
PNG
(CHEMBL3948984)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C12H11N3O3S2/c1-18-12-14-15-7-10(13-11(15)19-12)8-3-5-9(6-4-8)20(2,16)17/h3-7H,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199417
PNG
(CHEMBL3963226)
Show SMILES COc1nn2cc(nc2s1)-c1c(F)cccc1F
Show InChI InChI=1S/C11H7F2N3OS/c1-17-11-15-16-5-8(14-10(16)18-11)9-6(12)3-2-4-7(9)13/h2-5H,1H3
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n/an/a 1.29E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199417
PNG
(CHEMBL3963226)
Show SMILES COc1nn2cc(nc2s1)-c1c(F)cccc1F
Show InChI InChI=1S/C11H7F2N3OS/c1-17-11-15-16-5-8(14-10(16)18-11)9-6(12)3-2-4-7(9)13/h2-5H,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199425
PNG
(CHEMBL3950308)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-3-2-4-8(5-7)12(13,14)15/h2-6H,1H3
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n/an/a 1.31E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199419
PNG
(CHEMBL3918711)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-4-2-3-5-8(7)12(13,14)15/h2-6H,1H3
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199425
PNG
(CHEMBL3950308)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-3-2-4-8(5-7)12(13,14)15/h2-6H,1H3
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199419
PNG
(CHEMBL3918711)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C12H8F3N3OS/c1-19-11-17-18-6-9(16-10(18)20-11)7-4-2-3-5-8(7)12(13,14)15/h2-6H,1H3
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n/an/a 1.33E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199440
PNG
(CHEMBL3909608)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H7Cl2N3OS/c1-17-11-15-16-5-9(14-10(16)18-11)6-2-3-7(12)8(13)4-6/h2-5H,1H3
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n/an/a 1.45E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199440
PNG
(CHEMBL3909608)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H7Cl2N3OS/c1-17-11-15-16-5-9(14-10(16)18-11)6-2-3-7(12)8(13)4-6/h2-5H,1H3
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n/an/a 1.46E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199418
PNG
(CHEMBL3973767)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C12H9F2N3O2S/c1-18-12-16-17-6-9(15-11(17)20-12)7-2-4-8(5-3-7)19-10(13)14/h2-6,10H,1H3
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n/an/a 2.51E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199418
PNG
(CHEMBL3973767)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C12H9F2N3O2S/c1-18-12-16-17-6-9(15-11(17)20-12)7-2-4-8(5-3-7)19-10(13)14/h2-6,10H,1H3
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n/an/a 2.54E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199426
PNG
(CHEMBL3905565)
Show SMILES CN(C)c1nn2cc(nc2s1)-c1c(F)cccc1F
Show InChI InChI=1S/C12H10F2N4S/c1-17(2)12-16-18-6-9(15-11(18)19-12)10-7(13)4-3-5-8(10)14/h3-6H,1-2H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199430
PNG
(CHEMBL3924666)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C11H8N4O3S/c1-18-11-13-14-6-8(12-10(14)19-11)7-4-2-3-5-9(7)15(16)17/h2-6H,1H3
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n/an/a 4.79E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199430
PNG
(CHEMBL3924666)
Show SMILES COc1nn2cc(nc2s1)-c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C11H8N4O3S/c1-18-11-13-14-6-8(12-10(14)19-11)7-4-2-3-5-9(7)15(16)17/h2-6H,1H3
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n/an/a 4.84E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199431
PNG
(CHEMBL3927486)
Show SMILES COc1nn2cc(nc2s1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H7F6N3OS/c1-23-11-21-22-5-9(20-10(22)24-11)6-2-7(12(14,15)16)4-8(3-6)13(17,18)19/h2-5H,1H3
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n/an/a 5.62E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199431
PNG
(CHEMBL3927486)
Show SMILES COc1nn2cc(nc2s1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H7F6N3OS/c1-23-11-21-22-5-9(20-10(22)24-11)6-2-7(12(14,15)16)4-8(3-6)13(17,18)19/h2-5H,1H3
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n/an/a 5.62E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199429
PNG
(CHEMBL3896629)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C11H8N4O3S/c1-18-11-13-14-6-9(12-10(14)19-11)7-3-2-4-8(5-7)15(16)17/h2-6H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199422
PNG
(CHEMBL3904669)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(O)cc1
Show InChI InChI=1S/C11H9N3O2S/c1-16-11-13-14-6-9(12-10(14)17-11)7-2-4-8(15)5-3-7/h2-6,15H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199415
PNG
(CHEMBL3906686)
Show SMILES CNc1nn2cc(nc2s1)-c1c(F)cccc1F
Show InChI InChI=1S/C11H8F2N4S/c1-14-10-16-17-5-8(15-11(17)18-10)9-6(12)3-2-4-7(9)13/h2-5H,1H3,(H,14,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 in human platelets assessed as inhibition of activating peptide-induced P-selectin activation

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199422
PNG
(CHEMBL3904669)
Show SMILES COc1nn2cc(nc2s1)-c1ccc(O)cc1
Show InChI InChI=1S/C11H9N3O2S/c1-16-11-13-14-6-9(12-10(14)17-11)7-2-4-8(15)5-3-7/h2-6,15H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199429
PNG
(CHEMBL3896629)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C11H8N4O3S/c1-18-11-13-14-6-9(12-10(14)19-11)7-3-2-4-8(5-7)15(16)17/h2-6H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response preincubated for 20 mins fo...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199428
PNG
(CHEMBL3890362)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(Cl)c1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-3-2-4-8(12)5-7/h2-6H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50199420
PNG
(CHEMBL3933579)
Show SMILES COc1nn2cc(nc2s1)-c1cc2cc(OC(F)(F)F)ccc2n1C
Show InChI InChI=1S/C15H11F3N4O2S/c1-21-11-4-3-9(24-15(16,17)18)5-8(11)6-12(21)10-7-22-13(19-10)25-14(20-22)23-2/h3-7H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR1 in human platelets assessed as inhibition of activating peptide-induced PAC1 binding response

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4


(Homo sapiens (Human))		BDBM50199428
PNG
(CHEMBL3890362)
Show SMILES COc1nn2cc(nc2s1)-c1cccc(Cl)c1
Show InChI InChI=1S/C11H8ClN3OS/c1-16-11-14-15-6-9(13-10(15)17-11)7-3-2-4-8(12)5-7/h2-6H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at PAR4 in human platelets assessed as inhibition of gamma-thrombin-induced PAC1 binding response preincubated for 20 mins follow...

Bioorg Med Chem Lett 26: 5481-5486 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.020
BindingDB Entry DOI: 10.7270/Q2P55QGD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%