| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
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| Ligand | BDBM50199424 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1621530 (CHEMBL3863813) |
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| IC50 | 407±n/a nM |
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| Citation |  Temple, KJ; Duvernay, MT; Maeng, JG; Blobaum, AL; Stauffer, SR; Hamm, HE; Lindsley, CW Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles. Bioorg Med Chem Lett26:5481-5486 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 4 |
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| Name: | Proteinase-activated receptor 4 |
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| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
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| Type: | Protein |
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| Mol. Mass.: | 41145.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI0 |
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| Residue: | 385 |
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| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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| BDBM50199424 |
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| n/a |
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| Name | BDBM50199424 |
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| Synonyms: | CHEMBL3946410 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H8FN3OS |
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| Mol. Mass. | 249.264 |
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| SMILES | COc1nn2cc(nc2s1)-c1ccc(F)cc1 |
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| Structure | 
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