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PubMed code 28662813

Compile data set for download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268732
PNG
(CHEMBL4062900)
Show SMILES CCN(Cc1ccccc1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C18H21NO2/c1-3-19(13-16-7-5-4-6-8-16)18(20)14-21-17-11-9-15(2)10-12-17/h4-12H,3,13-14H2,1-2H3
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n/an/an/an/a 1.88E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268745
PNG
(CHEMBL4087060)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1O
Show InChI InChI=1S/C16H19NO3S/c1-3-17(10-13-5-4-8-21-13)16(19)11-20-15-7-6-12(2)9-14(15)18/h4-9,18H,3,10-11H2,1-2H3
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n/an/an/an/a 8n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268746
PNG
(CHEMBL4097943)
Show SMILES CCN(Cc1cccs1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C17H17NO3S/c1-2-18(11-14-4-3-9-22-14)17(19)8-6-13-5-7-15-16(10-13)21-12-20-15/h3-10H,2,11-12H2,1H3/b8-6+
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n/an/an/an/a 0.700n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268747
PNG
(CHEMBL4070838)
Show SMILES Cc1ccc(\C=C\C(=O)N(Cc2cccs2)c2ccn[nH]2)cc1
Show InChI InChI=1S/C18H17N3OS/c1-14-4-6-15(7-5-14)8-9-18(22)21(17-10-11-19-20-17)13-16-3-2-12-23-16/h2-12H,13H2,1H3,(H,19,20)/b9-8+
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n/an/an/an/a 0.00400n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268748
PNG
(CHEMBL4069241)
Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(Cc1cccs1)c1ccn[nH]1
Show InChI InChI=1S/C18H15N3O3S/c22-18(6-4-13-3-5-15-16(10-13)24-12-23-15)21(17-7-8-19-20-17)11-14-2-1-9-25-14/h1-10H,11-12H2,(H,19,20)/b6-4+
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n/an/an/an/a 0.00200n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268752
PNG
(CHEMBL4086513)
Show SMILES COCCN(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H21NO3S/c1-14-5-7-15(8-6-14)21-13-17(19)18(9-10-20-2)12-16-4-3-11-22-16/h3-8,11H,9-10,12-13H2,1-2H3
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n/an/an/an/a 400n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268762
PNG
(CHEMBL4091813)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccccc2)cc1
Show InChI InChI=1S/C20H19NO2S/c1-16-9-11-18(12-10-16)23-15-20(22)21(14-19-8-5-13-24-19)17-6-3-2-4-7-17/h2-13H,14-15H2,1H3
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n/an/an/an/a 23n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268807
PNG
(CHEMBL4104665)
Show SMILES CCN(Cc1cncs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C15H18N2O2S/c1-3-17(9-14-8-16-11-20-14)15(18)10-19-13-6-4-12(2)5-7-13/h4-8,11H,3,9-10H2,1-2H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268811
PNG
(CHEMBL4067773)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccccn2)cc1
Show InChI InChI=1S/C19H18N2O2S/c1-15-7-9-16(10-8-15)23-14-19(22)21(13-17-5-4-12-24-17)18-6-2-3-11-20-18/h2-12H,13-14H2,1H3
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n/an/an/an/a 200n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268817
PNG
(CHEMBL4084970)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H16F3NO2S/c1-2-20(10-14-4-3-9-23-14)15(21)11-22-13-7-5-12(6-8-13)16(17,18)19/h3-9H,2,10-11H2,1H3
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n/an/an/an/a 236n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268733
PNG
(CHEMBL4090832)
Show SMILES CCN(Cc1ccccn1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H20N2O2/c1-3-19(12-15-6-4-5-11-18-15)17(20)13-21-16-9-7-14(2)8-10-16/h4-11H,3,12-13H2,1-2H3
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n/an/an/an/a 1.60E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268734
PNG
(CHEMBL4066698)
Show SMILES CCN(Cc1cccnc1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H20N2O2/c1-3-19(12-15-5-4-10-18-11-15)17(20)13-21-16-8-6-14(2)7-9-16/h4-11H,3,12-13H2,1-2H3
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n/an/an/an/a 1.54E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268757
PNG
(CHEMBL4084023)
Show SMILES CCC(C)N(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C18H23NO2S/c1-4-15(3)19(12-17-6-5-11-22-17)18(20)13-21-16-9-7-14(2)8-10-16/h5-11,15H,4,12-13H2,1-3H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268761
PNG
(CHEMBL4091795)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)C2COC2)cc1
Show InChI InChI=1S/C17H19NO3S/c1-13-4-6-15(7-5-13)21-12-17(19)18(14-10-20-11-14)9-16-3-2-8-22-16/h2-8,14H,9-12H2,1H3
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n/an/an/an/a 2.30E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268769
PNG
(CHEMBL4087522)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-13-4-6-14(7-5-13)22-12-17(21)20(16-8-9-18-19-16)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 0.200n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268770
PNG
(CHEMBL4105385)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2cn[nH]c2)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-13-4-6-15(7-5-13)22-12-17(21)20(14-9-18-19-10-14)11-16-3-2-8-23-16/h2-10H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 1.40n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268812
PNG
(CHEMBL4077389)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2cccnc2)cc1
Show InChI InChI=1S/C19H18N2O2S/c1-15-6-8-17(9-7-15)23-14-19(22)21(13-18-5-3-11-24-18)16-4-2-10-20-12-16/h2-12H,13-14H2,1H3
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n/an/an/an/a 198n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268813
PNG
(CHEMBL4094300)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccncc2)cc1
Show InChI InChI=1S/C19H18N2O2S/c1-15-4-6-17(7-5-15)23-14-19(22)21(13-18-3-2-12-24-18)16-8-10-20-11-9-16/h2-12H,13-14H2,1H3
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n/an/an/an/a 52n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268818
PNG
(CHEMBL4102922)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(OC)cc1
Show InChI InChI=1S/C16H19NO3S/c1-3-17(11-15-5-4-10-21-15)16(18)12-20-14-8-6-13(19-2)7-9-14/h4-10H,3,11-12H2,1-2H3
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n/an/an/an/a 120n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268838
PNG
(CHEMBL4072650)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2nccs2)cc1
Show InChI InChI=1S/C17H16N2O2S2/c1-13-4-6-14(7-5-13)21-12-16(20)19(17-18-8-10-23-17)11-15-3-2-9-22-15/h2-10H,11-12H2,1H3
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n/an/an/an/a 2.24E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268735
PNG
(CHEMBL4059464)
Show SMILES CCN(Cc1cccs1)C(=O)COc1cc(C)ccc1O
Show InChI InChI=1S/C16H19NO3S/c1-3-17(10-13-5-4-8-21-13)16(19)11-20-15-9-12(2)6-7-14(15)18/h4-9,18H,3,10-11H2,1-2H3
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n/an/an/an/a 24n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268760
PNG
(CHEMBL4102011)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)C(C)(C)C)cc1
Show InChI InChI=1S/C18H23NO2S/c1-14-7-9-15(10-8-14)21-13-17(20)19(18(2,3)4)12-16-6-5-11-22-16/h5-11H,12-13H2,1-4H3
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n/an/an/an/a 1.10E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268763
PNG
(CHEMBL4064052)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccon2)cc1
Show InChI InChI=1S/C17H16N2O3S/c1-13-4-6-14(7-5-13)21-12-17(20)19(16-8-9-22-18-16)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268764
PNG
(CHEMBL4099556)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ncco2)cc1
Show InChI InChI=1S/C17H16N2O3S/c1-13-4-6-14(7-5-13)22-12-16(20)19(17-18-8-9-21-17)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3
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n/an/an/an/a 0.300n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268797
PNG
(CHEMBL4086763)
Show SMILES CCN(Cc1nccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C15H18N2O2S/c1-3-17(10-14-16-8-9-20-14)15(18)11-19-13-6-4-12(2)5-7-13/h4-9H,3,10-11H2,1-2H3
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n/an/an/an/a 3.06E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268808
PNG
(CHEMBL4105242)
Show SMILES CCN(Cc1ccsc1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C16H19NO2S/c1-3-17(10-14-8-9-20-12-14)16(18)11-19-15-6-4-13(2)5-7-15/h4-9,12H,3,10-11H2,1-2H3
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n/an/an/an/a 88n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268841
PNG
(CHEMBL4071703)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)C2CC2)cc1
Show InChI InChI=1S/C17H19NO2S/c1-13-4-8-15(9-5-13)20-12-17(19)18(14-6-7-14)11-16-3-2-10-21-16/h2-5,8-10,14H,6-7,11-12H2,1H3
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n/an/an/an/a 8n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268718
PNG
(CHEMBL4071883)
Show SMILES CCN(Cc1cccs1)C(=O)C[C@H](O)c1ccccc1 |r|
Show InChI InChI=1S/C16H19NO2S/c1-2-17(12-14-9-6-10-20-14)16(19)11-15(18)13-7-4-3-5-8-13/h3-10,15,18H,2,11-12H2,1H3/t15-/m0/s1
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n/an/an/an/a 5.20E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268720
PNG
(CHEMBL4067021)
Show SMILES CCN(Cc1cccs1)C(=O)c1cc2cc(C)ccc2s1
Show InChI InChI=1S/C17H17NOS2/c1-3-18(11-14-5-4-8-20-14)17(19)16-10-13-9-12(2)6-7-15(13)21-16/h4-10H,3,11H2,1-2H3
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n/an/an/an/a 1.60E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268723
PNG
(CHEMBL4093292)
Show SMILES CCN(Cc1cc[nH]c1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C16H20N2O2/c1-3-18(11-14-8-9-17-10-14)16(19)12-20-15-6-4-13(2)5-7-15/h4-10,17H,3,11-12H2,1-2H3
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n/an/an/an/a 2.18E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268724
PNG
(CHEMBL4091381)
Show SMILES COc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1
Show InChI InChI=1S/C17H17N3O3S/c1-22-13-4-6-14(7-5-13)23-12-17(21)20(16-8-9-18-19-16)11-15-3-2-10-24-15/h2-10H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 3.70n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268730
PNG
(CHEMBL4091183)
Show SMILES Cc1ccc2oc(cc2c1)C(=O)N(Cc1cccs1)c1ccn[nH]1
Show InChI InChI=1S/C18H15N3O2S/c1-12-4-5-15-13(9-12)10-16(23-15)18(22)21(17-6-7-19-20-17)11-14-3-2-8-24-14/h2-10H,11H2,1H3,(H,19,20)
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n/an/an/an/a 40n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268755
PNG
(CHEMBL4067932)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)C2CCCCC2)cc1
Show InChI InChI=1S/C20H25NO2S/c1-16-9-11-18(12-10-16)23-15-20(22)21(14-19-8-5-13-24-19)17-6-3-2-4-7-17/h5,8-13,17H,2-4,6-7,14-15H2,1H3
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n/an/an/an/a 4.00E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268772
PNG
(CHEMBL4080738)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2nccn2C)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-14-5-7-15(8-6-14)23-13-17(22)21(12-16-4-3-11-24-16)18-19-9-10-20(18)2/h3-11H,12-13H2,1-2H3
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n/an/an/an/a 1.79E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268830
PNG
(CHEMBL4060474)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc2COCc2c1
Show InChI InChI=1S/C17H19NO3S/c1-2-18(9-16-4-3-7-22-16)17(19)12-21-15-6-5-13-10-20-11-14(13)8-15/h3-8H,2,9-12H2,1H3
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n/an/an/an/a 61n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268715
PNG
(CHEMBL4090221)
Show SMILES CCN(Cc1cccs1)C(=O)C(C)Oc1ccc(C)cc1
Show InChI InChI=1S/C17H21NO2S/c1-4-18(12-16-6-5-11-21-16)17(19)14(3)20-15-9-7-13(2)8-10-15/h5-11,14H,4,12H2,1-3H3
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n/an/an/an/a 889n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268722
PNG
(CHEMBL4086590)
Show SMILES CCN(Cc1ccco1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C16H19NO3/c1-3-17(11-15-5-4-10-19-15)16(18)12-20-14-8-6-13(2)7-9-14/h4-10H,3,11-12H2,1-2H3
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n/an/an/an/a 489n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268749
PNG
(CHEMBL4097005)
Show SMILES O=C(COc1ccc2OCOc2c1)N(Cc1cccs1)c1ccn[nH]1
Show InChI InChI=1S/C17H15N3O4S/c21-17(10-22-12-3-4-14-15(8-12)24-11-23-14)20(16-5-6-18-19-16)9-13-2-1-7-25-13/h1-8H,9-11H2,(H,18,19)
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n/an/an/an/a 0.600n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268773
PNG
(CHEMBL4075397)
Show SMILES Cc1n[nH]c(C)c1N(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O2S/c1-13-6-8-16(9-7-13)24-12-18(23)22(11-17-5-4-10-25-17)19-14(2)20-21-15(19)3/h4-10H,11-12H2,1-3H3,(H,20,21)
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n/an/an/an/a 0.300n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268816
PNG
(CHEMBL4065047)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(cc1)C(C)C
Show InChI InChI=1S/C18H23NO2S/c1-4-19(12-17-6-5-11-22-17)18(20)13-21-16-9-7-15(8-10-16)14(2)3/h5-11,14H,4,12-13H2,1-3H3
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n/an/an/an/a 397n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268823
PNG
(CHEMBL4079334)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(CC)cc1
Show InChI InChI=1S/C17H21NO2S/c1-3-14-7-9-15(10-8-14)20-13-17(19)18(4-2)12-16-6-5-11-21-16/h5-11H,3-4,12-13H2,1-2H3
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n/an/an/an/a 67n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268826
PNG
(CHEMBL4087468)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(F)cc1
Show InChI InChI=1S/C15H16FNO2S/c1-2-17(10-14-4-3-9-20-14)15(18)11-19-13-7-5-12(16)6-8-13/h3-9H,2,10-11H2,1H3
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n/an/an/an/a 422n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268827
PNG
(CHEMBL4103845)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClNO2S/c1-2-17(10-14-4-3-9-20-14)15(18)11-19-13-7-5-12(16)6-8-13/h3-9H,2,10-11H2,1H3
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n/an/an/an/a 39n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268832
PNG
(CHEMBL4096839)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C16H19NO2S/c1-3-17(11-15-5-4-10-20-15)16(18)12-19-14-8-6-13(2)7-9-14/h4-10H,3,11-12H2,1-2H3
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n/an/an/an/a 8n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268834
PNG
(CHEMBL4083043)
Show SMILES CCN(Cc1cccn1C)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H22N2O2/c1-4-19(12-15-6-5-11-18(15)3)17(20)13-21-16-9-7-14(2)8-10-16/h5-11H,4,12-13H2,1-3H3
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n/an/an/an/a 2.13E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268835
PNG
(CHEMBL4063252)
Show SMILES CCN(Cc1cccs1)C(=O)\C=C\c1ccc(C)cc1
Show InChI InChI=1S/C17H19NOS/c1-3-18(13-16-5-4-12-20-16)17(19)11-10-15-8-6-14(2)7-9-15/h4-12H,3,13H2,1-2H3/b11-10+
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n/an/an/an/a 2n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268842
PNG
(CHEMBL4064027)
Show SMILES Cc1ccc(OCC(=O)N(CCO)Cc2cccs2)cc1
Show InChI InChI=1S/C16H19NO3S/c1-13-4-6-14(7-5-13)20-12-16(19)17(8-9-18)11-15-3-2-10-21-15/h2-7,10,18H,8-9,11-12H2,1H3
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n/an/an/an/a 900n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268719
PNG
(CHEMBL4093598)
Show SMILES CCN(Cc1cccs1)C(=O)c1cc2cc(C)ccc2o1
Show InChI InChI=1S/C17H17NO2S/c1-3-18(11-14-5-4-8-21-14)17(19)16-10-13-9-12(2)6-7-15(13)20-16/h4-10H,3,11H2,1-2H3
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n/an/an/an/a 120n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268771
PNG
(CHEMBL4074235)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2cnn(C)c2)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-14-5-7-16(8-6-14)23-13-18(22)21(12-17-4-3-9-24-17)15-10-19-20(2)11-15/h3-11H,12-13H2,1-2H3
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n/an/an/an/a 6.30E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268791
PNG
(CHEMBL4076572)
Show SMILES CCN(Cc1ccc(C)s1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H21NO2S/c1-4-18(11-16-10-7-14(3)21-16)17(19)12-20-15-8-5-13(2)6-9-15/h5-10H,4,11-12H2,1-3H3
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n/an/an/an/a 178n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268809
PNG
(CHEMBL4094279)
Show SMILES Cc1ccc(OCC(=O)N(O)Cc2cccs2)cc1
Show InChI InChI=1S/C14H15NO3S/c1-11-4-6-12(7-5-11)18-10-14(16)15(17)9-13-3-2-8-19-13/h2-8,17H,9-10H2,1H3
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n/an/an/an/a 8.00E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268814
PNG
(CHEMBL4092730)
Show SMILES CCCc1ccc(OCC(=O)N(CC)Cc2cccs2)cc1
Show InChI InChI=1S/C18H23NO2S/c1-3-6-15-8-10-16(11-9-15)21-14-18(20)19(4-2)13-17-7-5-12-22-17/h5,7-12H,3-4,6,13-14H2,1-2H3
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n/an/an/an/a 1.81E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268821
PNG
(CHEMBL4073663)
Show SMILES CC(C)CN(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C18H23NO2S/c1-14(2)11-19(12-17-5-4-10-22-17)18(20)13-21-16-8-6-15(3)7-9-16/h4-10,14H,11-13H2,1-3H3
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n/an/an/an/a 900n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268822
PNG
(CHEMBL4077232)
Show SMILES CCN(Cc1cccs1)C(=O)COc1cccc(C)c1
Show InChI InChI=1S/C16H19NO2S/c1-3-17(11-15-8-5-9-20-15)16(18)12-19-14-7-4-6-13(2)10-14/h4-10H,3,11-12H2,1-2H3
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n/an/an/an/a 97n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268824
PNG
(CHEMBL4074700)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(CO)cc1
Show InChI InChI=1S/C16H19NO3S/c1-2-17(10-15-4-3-9-21-15)16(19)12-20-14-7-5-13(11-18)6-8-14/h3-9,18H,2,10-12H2,1H3
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n/an/an/an/a 2.19E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268833
PNG
(CHEMBL4101022)
Show SMILES CCN(Cc1ccoc1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C16H19NO3/c1-3-17(10-14-8-9-19-11-14)16(18)12-20-15-6-4-13(2)5-7-15/h4-9,11H,3,10,12H2,1-2H3
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n/an/an/an/a 136n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268836
PNG
(CHEMBL4072895)
Show SMILES CCN(Cc1cccs1)C(=O)c1cc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C17H18N2OS/c1-3-19(11-14-5-4-8-21-14)17(20)16-10-13-9-12(2)6-7-15(13)18-16/h4-10,18H,3,11H2,1-2H3
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n/an/an/an/a 2.01E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268840
PNG
(CHEMBL4089135)
Show SMILES CC(C)N(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H21NO2S/c1-13(2)18(11-16-5-4-10-21-16)17(19)12-20-15-8-6-14(3)7-9-15/h4-10,13H,11-12H2,1-3H3
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n/an/an/an/a 70n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268731
PNG
(CHEMBL4098555)
Show SMILES CCN(Cc1c[nH]nn1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C14H18N4O2/c1-3-18(9-12-8-15-17-16-12)14(19)10-20-13-6-4-11(2)5-7-13/h4-8H,3,9-10H2,1-2H3,(H,15,16,17)
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n/an/an/an/a 3.11E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268753
PNG
(CHEMBL4100340)
Show SMILES CN(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C15H17NO2S/c1-12-5-7-13(8-6-12)18-11-15(17)16(2)10-14-4-3-9-19-14/h3-9H,10-11H2,1-2H3
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n/an/an/an/a 400n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268754
PNG
(CHEMBL1457614)
Show SMILES Cc1ccc(OCC(=O)NCc2cccs2)cc1
Show InChI InChI=1S/C14H15NO2S/c1-11-4-6-12(7-5-11)17-10-14(16)15-9-13-3-2-8-18-13/h2-8H,9-10H2,1H3,(H,15,16)
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n/an/an/an/a 2.50E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268756
PNG
(CHEMBL4092493)
Show SMILES Cc1ccc(OCC(=O)N(CC=C)Cc2cccs2)cc1
Show InChI InChI=1S/C17H19NO2S/c1-3-10-18(12-16-5-4-11-21-16)17(19)13-20-15-8-6-14(2)7-9-15/h3-9,11H,1,10,12-13H2,2H3
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n/an/an/an/a 20n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268819
PNG
(CHEMBL4084052)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2cnccn2)cc1
Show InChI InChI=1S/C18H17N3O2S/c1-14-4-6-15(7-5-14)23-13-18(22)21(12-16-3-2-10-24-16)17-11-19-8-9-20-17/h2-11H,12-13H2,1H3
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n/an/an/an/a 1.24E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268829
PNG
(CHEMBL4082377)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc2CCCCc2c1
Show InChI InChI=1S/C19H23NO2S/c1-2-20(13-18-8-5-11-23-18)19(21)14-22-17-10-9-15-6-3-4-7-16(15)12-17/h5,8-12H,2-4,6-7,13-14H2,1H3
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n/an/an/an/a 689n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268831
PNG
(CHEMBL4078818)
Show SMILES CCCN(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C17H21NO2S/c1-3-10-18(12-16-5-4-11-21-16)17(19)13-20-15-8-6-14(2)7-9-15/h4-9,11H,3,10,12-13H2,1-2H3
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n/an/an/an/a 40n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268837
PNG
(CHEMBL4072494)
Show SMILES Cc1n[nH]cc1N(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-13-5-7-15(8-6-13)23-12-18(22)21(11-16-4-3-9-24-16)17-10-19-20-14(17)2/h3-10H,11-12H2,1-2H3,(H,19,20)
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n/an/an/an/a 0.400n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268716
PNG
(CHEMBL4069157)
Show SMILES CCN(Cc1cccs1)C(=O)C(C)(C)Oc1ccc(C)cc1
Show InChI InChI=1S/C18H23NO2S/c1-5-19(13-16-7-6-12-22-16)17(20)18(3,4)21-15-10-8-14(2)9-11-15/h6-12H,5,13H2,1-4H3
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n/an/an/an/a 1.10E+4n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268717
PNG
(CHEMBL4091126)
Show SMILES CCN(Cc1cccs1)C(=O)CCc1ccc(C)cc1
Show InChI InChI=1S/C17H21NOS/c1-3-18(13-16-5-4-12-20-16)17(19)11-10-15-8-6-14(2)7-9-15/h4-9,12H,3,10-11,13H2,1-2H3
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n/an/an/an/a 93n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268728
PNG
(CHEMBL4087469)
Show SMILES CCN(Cc1cccs1)C(=O)c1cc2cc(OC)ccc2o1
Show InChI InChI=1S/C17H17NO3S/c1-3-18(11-14-5-4-8-22-14)17(19)16-10-12-9-13(20-2)6-7-15(12)21-16/h4-10H,3,11H2,1-2H3
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n/an/an/an/a 80n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268729
PNG
(CHEMBL4060261)
Show SMILES COc1ccc2oc(cc2c1)C(=O)N(Cc1cccs1)c1ccn[nH]1
Show InChI InChI=1S/C18H15N3O3S/c1-23-13-4-5-15-12(9-13)10-16(24-15)18(22)21(17-6-7-19-20-17)11-14-3-2-8-25-14/h2-10H,11H2,1H3,(H,19,20)
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n/an/an/an/a 1.10n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268750
PNG
(CHEMBL4064391)
Show SMILES O=C(COc1ccc2CCCc2c1)N(Cc1cccs1)c1ccn[nH]1
Show InChI InChI=1S/C19H19N3O2S/c23-19(13-24-16-7-6-14-3-1-4-15(14)11-16)22(18-8-9-20-21-18)12-17-5-2-10-25-17/h2,5-11H,1,3-4,12-13H2,(H,20,21)
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n/an/an/an/a 0.00100n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268751
PNG
(CHEMBL4065074)
Show SMILES Cc1ccc(OCC(=O)N(CCCO)Cc2cccs2)cc1
Show InChI InChI=1S/C17H21NO3S/c1-14-5-7-15(8-6-14)21-13-17(20)18(9-3-10-19)12-16-4-2-11-22-16/h2,4-8,11,19H,3,9-10,12-13H2,1H3
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n/an/an/an/a 3.00E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268788
PNG
(CHEMBL4099411)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccn(C)n2)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-14-5-7-15(8-6-14)23-13-18(22)21(12-16-4-3-11-24-16)17-9-10-20(2)19-17/h3-11H,12-13H2,1-2H3
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n/an/an/an/a 855n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268789
PNG
(CHEMBL4063891)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccccc1
Show InChI InChI=1S/C15H17NO2S/c1-2-16(11-14-9-6-10-19-14)15(17)12-18-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268790
PNG
(CHEMBL4091671)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccccc1C
Show InChI InChI=1S/C16H19NO2S/c1-3-17(11-14-8-6-10-20-14)16(18)12-19-15-9-5-4-7-13(15)2/h4-10H,3,11-12H2,1-2H3
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n/an/an/an/a 192n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268810
PNG
(CHEMBL4095201)
Show SMILES CON(Cc1cccs1)C(=O)COc1ccc(C)cc1
Show InChI InChI=1S/C15H17NO3S/c1-12-5-7-13(8-6-12)19-11-15(17)16(18-2)10-14-4-3-9-20-14/h3-9H,10-11H2,1-2H3
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n/an/an/an/a 10n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268820
PNG
(CHEMBL4102033)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ncccn2)cc1
Show InChI InChI=1S/C18H17N3O2S/c1-14-5-7-15(8-6-14)23-13-17(22)21(12-16-4-2-11-24-16)18-19-9-3-10-20-18/h2-11H,12-13H2,1H3
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n/an/an/an/a 3.70E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268825
PNG
(CHEMBL4095174)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(cc1)C#N
Show InChI InChI=1S/C16H16N2O2S/c1-2-18(11-15-4-3-9-21-15)16(19)12-20-14-7-5-13(10-17)6-8-14/h3-9H,2,11-12H2,1H3
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n/an/an/an/a 1.99E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268828
PNG
(CHEMBL4079591)
Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc2CCCc2c1
Show InChI InChI=1S/C18H21NO2S/c1-2-19(12-17-7-4-10-22-17)18(20)13-21-16-9-8-14-5-3-6-15(14)11-16/h4,7-11H,2-3,5-6,12-13H2,1H3
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n/an/an/an/a 0.800n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50268839
PNG
(CHEMBL4089781)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccnn2C)cc1
Show InChI InChI=1S/C18H19N3O2S/c1-14-5-7-15(8-6-14)23-13-18(22)21(12-16-4-3-11-24-16)17-9-10-19-20(17)2/h3-11H,12-13H2,1-2H3
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n/an/an/an/a 422n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%