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PubMed code 28666737

Compile data set for download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268933
PNG
(CHEMBL4093173)
Show SMILES CCc1cnc(nc1)N1CCC(COc2ccc(nc2)-c2ccc(cc2)C(=O)N(C)OC)CC1
Show InChI InChI=1S/C26H31N5O3/c1-4-19-15-28-26(29-16-19)31-13-11-20(12-14-31)18-34-23-9-10-24(27-17-23)21-5-7-22(8-6-21)25(32)30(2)33-3/h5-10,15-17,20H,4,11-14,18H2,1-3H3
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n/an/an/an/a 319n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268939
PNG
(CHEMBL4061409)
Show SMILES CON(C)C(=O)c1ccc(cc1)-c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C24H31N3O5/c1-17(2)32-24(29)27-13-11-18(12-14-27)16-31-21-9-10-22(25-15-21)19-5-7-20(8-6-19)23(28)26(3)30-4/h5-10,15,17-18H,11-14,16H2,1-4H3
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n/an/an/an/a 155n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268945
PNG
(CHEMBL4105139)
Show SMILES CON(C)C(=O)c1ccc(cc1)-c1csc2c(ncnc12)N(C)C1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C25H31N5O4S/c1-16(2)34-25(32)30-12-10-19(11-13-30)28(3)23-22-21(26-15-27-23)20(14-35-22)17-6-8-18(9-7-17)24(31)29(4)33-5/h6-9,14-16,19H,10-13H2,1-5H3
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n/an/an/an/a 156n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268929
PNG
(CHEMBL4087235)
Show SMILES CON(C)C(=O)c1ccc(cc1)-c1csc2c(OC3CCN(CC3)C(=O)OC(C)(C)C)ncnc12
Show InChI InChI=1S/C25H30N4O5S/c1-25(2,3)34-24(31)29-12-10-18(11-13-29)33-22-21-20(26-15-27-22)19(14-35-21)16-6-8-17(9-7-16)23(30)28(4)32-5/h6-9,14-15,18H,10-13H2,1-5H3
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n/an/an/an/a 64n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268931
PNG
(CHEMBL4099911)
Show SMILES CON(C)C(=O)c1ccc(cc1F)-c1csc2c(OC3CCN(CC3)C(=O)OC(C)(C)C)ncnc12
Show InChI InChI=1S/C25H29FN4O5S/c1-25(2,3)35-24(32)30-10-8-16(9-11-30)34-22-21-20(27-14-28-22)18(13-36-21)15-6-7-17(19(26)12-15)23(31)29(4)33-5/h6-7,12-14,16H,8-11H2,1-5H3
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n/an/an/an/a 57n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268932
PNG
(CHEMBL4081913)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)Oc1ncnc2c(csc12)-c1ccc(C(=O)N(C)OC)c(F)c1
Show InChI InChI=1S/C26H27FN6O3S/c1-4-16-12-28-26(29-13-16)33-9-7-18(8-10-33)36-24-23-22(30-15-31-24)20(14-37-23)17-5-6-19(21(27)11-17)25(34)32(2)35-3/h5-6,11-15,18H,4,7-10H2,1-3H3
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n/an/an/an/a 105n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268943
PNG
(CHEMBL4089778)
Show SMILES CCc1cnc(nc1)N1CCC(COc2ccc(nc2)-c2ccc(C(=O)N(C)OC)c(F)c2)CC1
Show InChI InChI=1S/C26H30FN5O3/c1-4-18-14-29-26(30-15-18)32-11-9-19(10-12-32)17-35-21-6-8-24(28-16-21)20-5-7-22(23(27)13-20)25(33)31(2)34-3/h5-8,13-16,19H,4,9-12,17H2,1-3H3
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n/an/an/an/a 77n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268944
PNG
(CHEMBL4070332)
Show SMILES CON(C)C(=O)c1ccc(cc1F)-c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C24H30FN3O5/c1-16(2)33-24(30)28-11-9-17(10-12-28)15-32-19-6-8-22(26-14-19)18-5-7-20(21(25)13-18)23(29)27(3)31-4/h5-8,13-14,16-17H,9-12,15H2,1-4H3
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n/an/an/an/a 92n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268956
PNG
(CHEMBL4067537)
Show SMILES CON(C)C(=O)c1ccc(cc1)-c1csc2c(ncnc12)N(C)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H33N5O4S/c1-26(2,3)35-25(33)31-13-11-19(12-14-31)29(4)23-22-21(27-16-28-23)20(15-36-22)17-7-9-18(10-8-17)24(32)30(5)34-6/h7-10,15-16,19H,11-14H2,1-6H3
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n/an/an/an/a 98n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268942
PNG
(CHEMBL4061666)
Show SMILES CON(C)C(=O)c1ccc(cc1F)-c1ccc(OCC2CCN(CC2)C(=O)OC(C)(C)C)cn1
Show InChI InChI=1S/C25H32FN3O5/c1-25(2,3)34-24(31)29-12-10-17(11-13-29)16-33-19-7-9-22(27-15-19)18-6-8-20(21(26)14-18)23(30)28(4)32-5/h6-9,14-15,17H,10-13,16H2,1-5H3
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n/an/an/an/a 73n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268928
PNG
(CHEMBL4097314)
Show SMILES CON(C)C(=O)c1ccc(cc1F)-c1csc2c(ncnc12)N(C)C1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C25H30FN5O4S/c1-15(2)35-25(33)31-10-8-17(9-11-31)29(3)23-22-21(27-14-28-23)19(13-36-22)16-6-7-18(20(26)12-16)24(32)30(4)34-5/h6-7,12-15,17H,8-11H2,1-5H3
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n/an/an/an/a 67n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268955
PNG
(CHEMBL4078440)
Show SMILES CN(C1CCN(CC1)C(=O)OC(C)(C)C)c1ncnc2c(csc12)-c1ccc(cc1)C(=O)NOCc1ccccc1
Show InChI InChI=1S/C31H35N5O4S/c1-31(2,3)40-30(38)36-16-14-24(15-17-36)35(4)28-27-26(32-20-33-28)25(19-41-27)22-10-12-23(13-11-22)29(37)34-39-18-21-8-6-5-7-9-21/h5-13,19-20,24H,14-18H2,1-4H3,(H,34,37)
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n/an/an/an/a 83n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268927
PNG
(CHEMBL4105014)
Show SMILES CON(C)C(=O)c1ccc(cc1F)-c1csc2c(ncnc12)N(C)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H32FN5O4S/c1-26(2,3)36-25(34)32-11-9-17(10-12-32)30(4)23-22-21(28-15-29-23)19(14-37-22)16-7-8-18(20(27)13-16)24(33)31(5)35-6/h7-8,13-15,17H,9-12H2,1-6H3
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n/an/an/an/a 53n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268930
PNG
(CHEMBL4064998)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)Oc1ncnc2c(csc12)-c1ccc(cc1)C(=O)N(C)OC
Show InChI InChI=1S/C26H28N6O3S/c1-4-17-13-27-26(28-14-17)32-11-9-20(10-12-32)35-24-23-22(29-16-30-24)21(15-36-23)18-5-7-19(8-6-18)25(33)31(2)34-3/h5-8,13-16,20H,4,9-12H2,1-3H3
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n/an/an/an/a 199n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268940
PNG
(CHEMBL4087173)
Show SMILES CC(C)(C)OC(=O)N1CCC(COc2ccc(nc2)-c2ccc(cc2)C(=O)N2CCCCO2)CC1
Show InChI InChI=1S/C27H35N3O5/c1-27(2,3)35-26(32)29-15-12-20(13-16-29)19-33-23-10-11-24(28-18-23)21-6-8-22(9-7-21)25(31)30-14-4-5-17-34-30/h6-11,18,20H,4-5,12-17,19H2,1-3H3
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n/an/an/an/a 321n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50268941
PNG
(CHEMBL4066367)
Show SMILES CON(C)C(=O)c1ccc(cc1)-c1ccc(OCC2CCN(CC2)C(=O)OC(C)(C)C)cn1
Show InChI InChI=1S/C25H33N3O5/c1-25(2,3)33-24(30)28-14-12-18(13-15-28)17-32-21-10-11-22(26-16-21)19-6-8-20(9-7-19)23(29)27(4)31-5/h6-11,16,18H,12-15,17H2,1-5H3
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n/an/an/an/a 171n/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHOK1 cells harboring CRE-luciferase after 6 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 27: 3909-3914 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.032
BindingDB Entry DOI: 10.7270/Q2NK3HHF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%