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PubMed code 28751196

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260423
PNG
(CHEMBL4104317)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cn(Cc3ccccc3)cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C28H29FN4O4/c1-17(2)11-20-13-22(26(35)37-3)28(21-12-19(29)9-10-23(21)31-27(28)36)33(20)25(34)24-15-32(16-30-24)14-18-7-5-4-6-8-18/h4-10,12,15-17,20,22H,11,13-14H2,1-3H3,(H,31,36)/t20-,22-,28+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260442
PNG
(CHEMBL4100976)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cn(C)cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C22H25FN4O4/c1-12(2)7-14-9-16(20(29)31-4)22(27(14)19(28)18-10-26(3)11-24-18)15-8-13(23)5-6-17(15)25-21(22)30/h5-6,8,10-12,14,16H,7,9H2,1-4H3,(H,25,30)/t14-,16-,22+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 helicase activity expressed in baculovirus infected Sf9 cells using 5'-[FITC]-...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260438
PNG
(CHEMBL4088975)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r|
Show InChI InChI=1S/C22H25N3O2/c1-14(2)12-16-13-15(3)22(17-8-4-5-9-18(17)24-21(22)27)25(16)20(26)19-10-6-7-11-23-19/h4-11,14-16H,12-13H2,1-3H3,(H,24,27)/t15-,16+,22+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260422
PNG
(CHEMBL4080080)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2c[nH]cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C21H23FN4O4/c1-11(2)6-13-8-15(19(28)30-3)21(26(13)18(27)17-9-23-10-24-17)14-7-12(22)4-5-16(14)25-20(21)29/h4-5,7,9-11,13,15H,6,8H2,1-3H3,(H,23,24)(H,25,29)/t13-,15-,21+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 helicase activity expressed in baculovirus infected Sf9 cells using 5'-[FITC]-...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260392
PNG
(CHEMBL4076145)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C23H24FN3O4/c1-13(2)10-15-12-17(21(29)31-3)23(27(15)20(28)19-6-4-5-9-25-19)16-11-14(24)7-8-18(16)26-22(23)30/h4-9,11,13,15,17H,10,12H2,1-3H3,(H,26,30)/t15-,17-,23+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260432
PNG
(CHEMBL4088974)
Show SMILES CC(C)C[C@H]1C[C@@H](CF)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r|
Show InChI InChI=1S/C22H24FN3O2/c1-14(2)11-16-12-15(13-23)22(17-7-3-4-8-18(17)25-21(22)28)26(16)20(27)19-9-5-6-10-24-19/h3-10,14-16H,11-13H2,1-2H3,(H,25,28)/t15-,16-,22-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260416
PNG
(CHEMBL4074224)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2nccn2C)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C22H25FN4O4/c1-12(2)9-14-11-16(20(29)31-4)22(27(14)19(28)18-24-7-8-26(18)3)15-10-13(23)5-6-17(15)25-21(22)30/h5-8,10,12,14,16H,9,11H2,1-4H3,(H,25,30)/t14-,16-,22+/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260427
PNG
(CHEMBL4076348)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17-,23+/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260427
PNG
(CHEMBL4076348)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17-,23+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260433
PNG
(CHEMBL4072226)
Show SMILES CC(C)C[C@H]1C[C@@H](CCl)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r|
Show InChI InChI=1S/C22H24ClN3O2/c1-14(2)11-16-12-15(13-23)22(17-7-3-4-8-18(17)25-21(22)28)26(16)20(27)19-9-5-6-10-24-19/h3-10,14-16H,11-13H2,1-2H3,(H,25,28)/t15-,16-,22-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260391
PNG
(CHEMBL4079310)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2cccc(F)c12 |r|
Show InChI InChI=1S/C23H24FN3O4/c1-13(2)11-14-12-15(21(29)31-3)23(27(14)20(28)18-8-4-5-10-25-18)19-16(24)7-6-9-17(19)26-22(23)30/h4-10,13-15H,11-12H2,1-3H3,(H,26,30)/t14-,15-,23-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260397
PNG
(CHEMBL4093245)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2c1cccc2F |r|
Show InChI InChI=1S/C23H24FN3O4/c1-13(2)11-14-12-16(21(29)31-3)23(27(14)20(28)18-9-4-5-10-25-18)15-7-6-8-17(24)19(15)26-22(23)30/h4-10,13-14,16H,11-12H2,1-3H3,(H,26,30)/t14-,16-,23+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260412
PNG
(CHEMBL4062845)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccn(C)n2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C22H25FN4O4/c1-12(2)9-14-11-16(20(29)31-4)22(27(14)19(28)18-7-8-26(3)25-18)15-10-13(23)5-6-17(15)24-21(22)30/h5-8,10,12,14,16H,9,11H2,1-4H3,(H,24,30)/t14-,16-,22+/m0/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260440
PNG
(CHEMBL4100905)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C23H24ClN3O4/c1-13(2)10-15-12-17(21(29)31-3)23(27(15)20(28)19-6-4-5-9-25-19)16-11-14(24)7-8-18(16)26-22(23)30/h4-9,11,13,15,17H,10,12H2,1-3H3,(H,26,30)/t15-,17-,23+/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260437
PNG
(CHEMBL4097700)
Show SMILES CC(C)C[C@H]1C[C@@H](CO)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r|
Show InChI InChI=1S/C22H25N3O3/c1-14(2)11-16-12-15(13-26)22(17-7-3-4-8-18(17)24-21(22)28)25(16)20(27)19-9-5-6-10-23-19/h3-10,14-16,26H,11-13H2,1-2H3,(H,24,28)/t15-,16-,22-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260425
PNG
(CHEMBL4099313)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1
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n/an/a 8.40E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260396
PNG
(CHEMBL4065602)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2cc(F)ccc12 |r|
Show InChI InChI=1S/C23H24FN3O4/c1-13(2)10-15-12-17(21(29)31-3)23(27(15)20(28)18-6-4-5-9-25-18)16-8-7-14(24)11-19(16)26-22(23)30/h4-9,11,13,15,17H,10,12H2,1-3H3,(H,26,30)/t15-,17-,23+/m0/s1
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n/an/a 8.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260431
PNG
(CHEMBL4076160)
Show SMILES CC(C)C[C@H]1C[C@@H](C(N)=O)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r|
Show InChI InChI=1S/C22H24N4O3/c1-13(2)11-14-12-16(19(23)27)22(15-7-3-4-8-17(15)25-21(22)29)26(14)20(28)18-9-5-6-10-24-18/h3-10,13-14,16H,11-12H2,1-2H3,(H2,23,27)(H,25,29)/t14-,16-,22+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260429
PNG
(CHEMBL4060638)
Show SMILES COC(=O)[C@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17+,23+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50260425
PNG
(CHEMBL4099313)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260406
PNG
(CHEMBL4084522)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccncc2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C23H24FN3O4/c1-13(2)10-16-12-18(21(29)31-3)23(27(16)20(28)14-6-8-25-9-7-14)17-11-15(24)4-5-19(17)26-22(23)30/h4-9,11,13,16,18H,10,12H2,1-3H3,(H,26,30)/t16-,18-,23+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260429
PNG
(CHEMBL4060638)
Show SMILES COC(=O)[C@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17+,23+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260430
PNG
(CHEMBL4076134)
Show SMILES Cl.CC(C)C[C@H]1C[C@@H](C(O)=O)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r|
Show InChI InChI=1S/C22H23N3O4.ClH/c1-13(2)11-14-12-16(20(27)28)22(15-7-3-4-8-17(15)24-21(22)29)25(14)19(26)18-9-5-6-10-23-18;/h3-10,13-14,16H,11-12H2,1-2H3,(H,24,29)(H,27,28);1H/t14-,16-,22+;/m0./s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260441
PNG
(CHEMBL4085493)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cccnc2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C23H24FN3O4/c1-13(2)9-16-11-18(21(29)31-3)23(27(16)20(28)14-5-4-8-25-12-14)17-10-15(24)6-7-19(17)26-22(23)30/h4-8,10,12-13,16,18H,9,11H2,1-3H3,(H,26,30)/t16-,18-,23+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-I


(Homo sapiens (Human))		BDBM50260426
PNG
(CHEMBL4073413)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of elF4G-induced full length recombinant human N-terminal His6-SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-I


(Homo sapiens (Human))		BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of elF4G-induced full length recombinant human N-terminal His6-SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260439
PNG
(CHEMBL4098071)
Show SMILES COC(=O)[C@@H]1C[C@H](Cc2ccccc2)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C26H23N3O4/c1-33-24(31)20-16-18(15-17-9-3-2-4-10-17)29(23(30)22-13-7-8-14-27-22)26(20)19-11-5-6-12-21(19)28-25(26)32/h2-14,18,20H,15-16H2,1H3,(H,28,32)/t18-,20-,26+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260403
PNG
(CHEMBL4103422)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccc2)[C@@]11C(=O)Nc2ccc(F)cc12 |r|
Show InChI InChI=1S/C24H25FN2O4/c1-14(2)11-17-13-19(22(29)31-3)24(27(17)21(28)15-7-5-4-6-8-15)18-12-16(25)9-10-20(18)26-23(24)30/h4-10,12,14,17,19H,11,13H2,1-3H3,(H,26,30)/t17-,19-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))		BDBM50260390
PNG
(CHEMBL4070683)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-FLAG-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260428
PNG
(CHEMBL4098860)
Show SMILES COC(=O)[C@H]1C[C@@H](CC(C)C)N(C(=O)c2ccccn2)[C@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17-,23+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-I


(Homo sapiens (Human))		BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of elF4G-induced full length recombinant human N-terminal His6-SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260436
PNG
(CHEMBL4088033)
Show SMILES COC(=O)[C@@H]1C[C@H](C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C20H19N3O4/c1-12-11-14(18(25)27-2)20(13-7-3-4-8-15(13)22-19(20)26)23(12)17(24)16-9-5-6-10-21-16/h3-10,12,14H,11H2,1-2H3,(H,22,26)/t12-,14-,20+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260434
PNG
(CHEMBL4060758)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)N(C)c2ccccc12 |r|
Show InChI InChI=1S/C24H27N3O4/c1-15(2)13-16-14-18(22(29)31-4)24(27(16)21(28)19-10-7-8-12-25-19)17-9-5-6-11-20(17)26(3)23(24)30/h5-12,15-16,18H,13-14H2,1-4H3/t16-,18-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260426
PNG
(CHEMBL4073413)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-I


(Homo sapiens (Human))		BDBM50260425
PNG
(CHEMBL4099313)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of elF4G-induced full length recombinant human N-terminal His6-SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase DHX29


(Homo sapiens (Human))		BDBM50260424
PNG
(CHEMBL4091579)
Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-FLAG-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50260426
PNG
(CHEMBL4073413)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase


(Homo sapiens (Human))		BDBM50260435
PNG
(CHEMBL4066737)
Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)Cc2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r|
Show InChI InChI=1S/C24H27N3O4/c1-15(2)12-17-14-19(22(29)31-3)24(18-9-4-5-10-20(18)26-23(24)30)27(17)21(28)13-16-8-6-7-11-25-16/h4-11,15,17,19H,12-14H2,1-3H3,(H,26,30)/t17-,19-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%