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PubMed code 28927786

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a<1n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261773
PNG
(CHEMBL4092337)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C18H17N5O2/c1-2-16(24)22-13-6-3-5-12(9-13)10-20-17-14(18(19)25)11-21-23-8-4-7-15(17)23/h2-9,11,20H,1,10H2,(H2,19,25)(H,22,24)
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n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261775
PNG
(CHEMBL4084598)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NS(=O)(=O)C=C)c1
Show InChI InChI=1S/C17H17N5O3S/c1-2-26(24,25)21-13-6-3-5-12(9-13)10-19-16-14(17(18)23)11-20-22-8-4-7-15(16)22/h2-9,11,19,21H,1,10H2,(H2,18,23)
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n/an/a 3.5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261771
PNG
(CHEMBL4072239)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1ccccc1
Show InChI InChI=1S/C19H18N4O/c20-19(24)16-13-22-18(23-15-9-5-2-6-10-15)11-17(16)21-12-14-7-3-1-4-8-14/h1-11,13H,12H2,(H2,20,24)(H2,21,22,23)
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n/an/a 4.5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261772
PNG
(CHEMBL4093318)
Show SMILES NC(=O)c1cnn2cc(cc2c1NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H18N4O/c22-21(26)18-13-24-25-14-17(16-9-5-2-6-10-16)11-19(25)20(18)23-12-15-7-3-1-4-8-15/h1-11,13-14,23H,12H2,(H2,22,26)
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261778
PNG
(CHEMBL4062471)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)Cn2sc3ccccc3c2=O)c1
Show InChI InChI=1S/C24H20N6O3S/c25-23(32)18-13-27-29-10-4-8-19(29)22(18)26-12-15-5-3-6-16(11-15)28-21(31)14-30-24(33)17-7-1-2-9-20(17)34-30/h1-11,13,26H,12,14H2,(H2,25,32)(H,28,31)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261776
PNG
(CHEMBL4066730)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)CC#N)c1
Show InChI InChI=1S/C18H16N6O2/c19-7-6-16(25)23-13-4-1-3-12(9-13)10-21-17-14(18(20)26)11-22-24-8-2-5-15(17)24/h1-5,8-9,11,21H,6,10H2,(H2,20,26)(H,23,25)
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 51n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK1/JAK3 in human PBMC derived T cell assessed as reduction in IL2-induced STAT3 phosphorylation after 30 mins by ELISA

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261795
PNG
(CHEMBL4071559)
Show SMILES CCC(=O)Nc1cccc(CNc2cc(Nc3ccccc3)ncc2C(N)=O)c1
Show InChI InChI=1S/C22H23N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h3-12,14H,2,13H2,1H3,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261772
PNG
(CHEMBL4093318)
Show SMILES NC(=O)c1cnn2cc(cc2c1NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H18N4O/c22-21(26)18-13-24-25-14-17(16-9-5-2-6-10-16)11-19(25)20(18)23-12-15-7-3-1-4-8-15/h1-11,13-14,23H,12H2,(H2,22,26)
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n/an/a 118n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261774
PNG
(CHEMBL4062932)
Show SMILES C\C=C\C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C19H19N5O2/c1-2-5-17(25)23-14-7-3-6-13(10-14)11-21-18-15(19(20)26)12-22-24-9-4-8-16(18)24/h2-10,12,21H,11H2,1H3,(H2,20,26)(H,23,25)/b5-2+
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n/an/a 175n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 180n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin) by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261778
PNG
(CHEMBL4062471)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)Cn2sc3ccccc3c2=O)c1
Show InChI InChI=1S/C24H20N6O3S/c25-23(32)18-13-27-29-10-4-8-19(29)22(18)26-12-15-5-3-6-16(11-15)28-21(31)14-30-24(33)17-7-1-2-9-20(17)34-30/h1-11,13,26H,12,14H2,(H2,25,32)(H,28,31)
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n/an/a 196n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261771
PNG
(CHEMBL4072239)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1ccccc1
Show InChI InChI=1S/C19H18N4O/c20-19(24)16-13-22-18(23-15-9-5-2-6-10-15)11-17(16)21-12-14-7-3-1-4-8-14/h1-11,13H,12H2,(H2,20,24)(H2,21,22,23)
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n/an/a 203n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261772
PNG
(CHEMBL4093318)
Show SMILES NC(=O)c1cnn2cc(cc2c1NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H18N4O/c22-21(26)18-13-24-25-14-17(16-9-5-2-6-10-16)11-19(25)20(18)23-12-15-7-3-1-4-8-15/h1-11,13-14,23H,12H2,(H2,22,26)
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n/an/a 214n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261771
PNG
(CHEMBL4072239)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1ccccc1
Show InChI InChI=1S/C19H18N4O/c20-19(24)16-13-22-18(23-15-9-5-2-6-10-15)11-17(16)21-12-14-7-3-1-4-8-14/h1-11,13H,12H2,(H2,20,24)(H2,21,22,23)
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n/an/a 219n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261778
PNG
(CHEMBL4062471)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)Cn2sc3ccccc3c2=O)c1
Show InChI InChI=1S/C24H20N6O3S/c25-23(32)18-13-27-29-10-4-8-19(29)22(18)26-12-15-5-3-6-16(11-15)28-21(31)14-30-24(33)17-7-1-2-9-20(17)34-30/h1-11,13,26H,12,14H2,(H2,25,32)(H,28,31)
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261776
PNG
(CHEMBL4066730)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)CC#N)c1
Show InChI InChI=1S/C18H16N6O2/c19-7-6-16(25)23-13-4-1-3-12(9-13)10-21-17-14(18(20)26)11-22-24-8-2-5-15(17)24/h1-5,8-9,11,21H,6,10H2,(H2,20,26)(H,23,25)
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n/an/a 264n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261772
PNG
(CHEMBL4093318)
Show SMILES NC(=O)c1cnn2cc(cc2c1NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H18N4O/c22-21(26)18-13-24-25-14-17(16-9-5-2-6-10-16)11-19(25)20(18)23-12-15-7-3-1-4-8-15/h1-11,13-14,23H,12H2,(H2,22,26)
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n/an/a 438n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261776
PNG
(CHEMBL4066730)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)CC#N)c1
Show InChI InChI=1S/C18H16N6O2/c19-7-6-16(25)23-13-4-1-3-12(9-13)10-21-17-14(18(20)26)11-22-24-8-2-5-15(17)24/h1-5,8-9,11,21H,6,10H2,(H2,20,26)(H,23,25)
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n/an/a 658n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261796
PNG
(CHEMBL4084173)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)COc2c(F)c(F)c(F)c(F)c2F)c1
Show InChI InChI=1S/C23H16F5N5O3/c24-16-17(25)19(27)22(20(28)18(16)26)36-10-15(34)32-12-4-1-3-11(7-12)8-30-21-13(23(29)35)9-31-33-6-2-5-14(21)33/h1-7,9,30H,8,10H2,(H2,29,35)(H,32,34)
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n/an/a 743n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261778
PNG
(CHEMBL4062471)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)Cn2sc3ccccc3c2=O)c1
Show InChI InChI=1S/C24H20N6O3S/c25-23(32)18-13-27-29-10-4-8-19(29)22(18)26-12-15-5-3-6-16(11-15)28-21(31)14-30-24(33)17-7-1-2-9-20(17)34-30/h1-11,13,26H,12,14H2,(H2,25,32)(H,28,31)
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n/an/a 745n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261771
PNG
(CHEMBL4072239)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1ccccc1
Show InChI InChI=1S/C19H18N4O/c20-19(24)16-13-22-18(23-15-9-5-2-6-10-15)11-17(16)21-12-14-7-3-1-4-8-14/h1-11,13H,12H2,(H2,20,24)(H2,21,22,23)
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n/an/a 774n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50261777
PNG
(CHEMBL4088027)
Show SMILES CN(C)\C=C(\C#N)C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C21H21N7O2/c1-27(2)13-15(10-22)21(30)26-16-6-3-5-14(9-16)11-24-19-17(20(23)29)12-25-28-8-4-7-18(19)28/h3-9,12-13,24H,11H2,1-2H3,(H2,23,29)(H,26,30)/b15-13-
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n/an/a 942n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261775
PNG
(CHEMBL4084598)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NS(=O)(=O)C=C)c1
Show InChI InChI=1S/C17H17N5O3S/c1-2-26(24,25)21-13-6-3-5-12(9-13)10-19-16-14(17(18)23)11-20-22-8-4-7-15(16)22/h2-9,11,19,21H,1,10H2,(H2,18,23)
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n/an/a 974n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261775
PNG
(CHEMBL4084598)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NS(=O)(=O)C=C)c1
Show InChI InChI=1S/C17H17N5O3S/c1-2-26(24,25)21-13-6-3-5-12(9-13)10-19-16-14(17(18)23)11-20-22-8-4-7-15(16)22/h2-9,11,19,21H,1,10H2,(H2,18,23)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261774
PNG
(CHEMBL4062932)
Show SMILES C\C=C\C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C19H19N5O2/c1-2-5-17(25)23-14-7-3-6-13(10-14)11-21-18-15(19(20)26)12-22-24-9-4-8-16(18)24/h2-10,12,21H,11H2,1H3,(H2,20,26)(H,23,25)/b5-2+
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n/an/a 1.42E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261773
PNG
(CHEMBL4092337)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C18H17N5O2/c1-2-16(24)22-13-6-3-5-12(9-13)10-20-17-14(18(19)25)11-21-23-8-4-7-15(17)23/h2-9,11,20H,1,10H2,(H2,19,25)(H,22,24)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261777
PNG
(CHEMBL4088027)
Show SMILES CN(C)\C=C(\C#N)C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C21H21N7O2/c1-27(2)13-15(10-22)21(30)26-16-6-3-5-14(9-16)11-24-19-17(20(23)29)12-25-28-8-4-7-18(19)28/h3-9,12-13,24H,11H2,1-2H3,(H2,23,29)(H,26,30)/b15-13-
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261796
PNG
(CHEMBL4084173)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)COc2c(F)c(F)c(F)c(F)c2F)c1
Show InChI InChI=1S/C23H16F5N5O3/c24-16-17(25)19(27)22(20(28)18(16)26)36-10-15(34)32-12-4-1-3-11(7-12)8-30-21-13(23(29)35)9-31-33-6-2-5-14(21)33/h1-7,9,30H,8,10H2,(H2,29,35)(H,32,34)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261796
PNG
(CHEMBL4084173)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)COc2c(F)c(F)c(F)c(F)c2F)c1
Show InChI InChI=1S/C23H16F5N5O3/c24-16-17(25)19(27)22(20(28)18(16)26)36-10-15(34)32-12-4-1-3-11(7-12)8-30-21-13(23(29)35)9-31-33-6-2-5-14(21)33/h1-7,9,30H,8,10H2,(H2,29,35)(H,32,34)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261773
PNG
(CHEMBL4092337)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C18H17N5O2/c1-2-16(24)22-13-6-3-5-12(9-13)10-20-17-14(18(19)25)11-21-23-8-4-7-15(17)23/h2-9,11,20H,1,10H2,(H2,19,25)(H,22,24)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261774
PNG
(CHEMBL4062932)
Show SMILES C\C=C\C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C19H19N5O2/c1-2-5-17(25)23-14-7-3-6-13(10-14)11-21-18-15(19(20)26)12-22-24-9-4-8-16(18)24/h2-10,12,21H,11H2,1H3,(H2,20,26)(H,23,25)/b5-2+
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261776
PNG
(CHEMBL4066730)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)CC#N)c1
Show InChI InChI=1S/C18H16N6O2/c19-7-6-16(25)23-13-4-1-3-12(9-13)10-21-17-14(18(20)26)11-22-24-8-2-5-15(17)24/h1-5,8-9,11,21H,6,10H2,(H2,20,26)(H,23,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261775
PNG
(CHEMBL4084598)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NS(=O)(=O)C=C)c1
Show InChI InChI=1S/C17H17N5O3S/c1-2-26(24,25)21-13-6-3-5-12(9-13)10-19-16-14(17(18)23)11-20-22-8-4-7-15(16)22/h2-9,11,19,21H,1,10H2,(H2,18,23)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261796
PNG
(CHEMBL4084173)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)COc2c(F)c(F)c(F)c(F)c2F)c1
Show InChI InChI=1S/C23H16F5N5O3/c24-16-17(25)19(27)22(20(28)18(16)26)36-10-15(34)32-12-4-1-3-11(7-12)8-30-21-13(23(29)35)9-31-33-6-2-5-14(21)33/h1-7,9,30H,8,10H2,(H2,29,35)(H,32,34)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261774
PNG
(CHEMBL4062932)
Show SMILES C\C=C\C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C19H19N5O2/c1-2-5-17(25)23-14-7-3-6-13(10-14)11-21-18-15(19(20)26)12-22-24-9-4-8-16(18)24/h2-10,12,21H,11H2,1H3,(H2,20,26)(H,23,25)/b5-2+
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261777
PNG
(CHEMBL4088027)
Show SMILES CN(C)\C=C(\C#N)C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C21H21N7O2/c1-27(2)13-15(10-22)21(30)26-16-6-3-5-14(9-16)11-24-19-17(20(23)29)12-25-28-8-4-7-18(19)28/h3-9,12-13,24H,11H2,1-2H3,(H2,23,29)(H,26,30)/b15-13-
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged JAK1 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261777
PNG
(CHEMBL4088027)
Show SMILES CN(C)\C=C(\C#N)C(=O)Nc1cccc(CNc2c(cnn3cccc23)C(N)=O)c1
Show InChI InChI=1S/C21H21N7O2/c1-27(2)13-15(10-22)21(30)26-16-6-3-5-14(9-16)11-24-19-17(20(23)29)12-25-28-8-4-7-18(19)28/h3-9,12-13,24H,11H2,1-2H3,(H2,23,29)(H,26,30)/b15-13-
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261773
PNG
(CHEMBL4092337)
Show SMILES NC(=O)c1cnn2cccc2c1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C18H17N5O2/c1-2-16(24)22-13-6-3-5-12(9-13)10-20-17-14(18(19)25)11-21-23-8-4-7-15(17)23/h2-9,11,20H,1,10H2,(H2,19,25)(H,22,24)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a>2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of full length human His-tagged BTK expressed in baculovirus expression system using GEEPLYWSFPAKKK-NH2 as substrate measured after 10 min...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK1/TYK2 in human PBMC derived T cell assessed as reduction in IFNa2a-induced STAT3 phosphorylation after 30 mins by ELISA

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged TYK2 (unknown origin) using fluoresceinated peptide as substrate after 3 hrs by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of EGFR (unknown origin) by caliper assay

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells after...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human TF1 cells assessed as reduction in EPO-induced STAT5A phosphorylation pretreated for 30 mins followed by EPO addition mea...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/an/an/a 6.56E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of full length human His-tagged BTK expressed in baculovirus expression system using GEEPLYWSFPAKKK-NH2 as substrate pretreated for 15 min...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/an/an/a 2.89E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of full length human His-tagged BTK expressed in baculovirus expression system using GEEPLYWSFPAKKK-NH2 as substrate pretreated for 45 min...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/an/an/a 1.58E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of full length human His-tagged BTK expressed in baculovirus expression system using GEEPLYWSFPAKKK-NH2 as substrate pretreated for 120 mi...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM50261794
PNG
(CHEMBL4065693)
Show SMILES NC(=O)c1cnc(Nc2ccccc2)cc1NCc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H21N5O2/c1-2-21(28)27-17-10-6-7-15(11-17)13-24-19-12-20(25-14-18(19)22(23)29)26-16-8-4-3-5-9-16/h2-12,14H,1,13H2,(H2,23,29)(H,27,28)(H2,24,25,26)
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n/an/an/an/a 1.98E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. Electronic address: james.kempson@bms.com.

Curated by ChEMBL


Assay Description
Inhibition of full length human His-tagged BTK expressed in baculovirus expression system using GEEPLYWSFPAKKK-NH2 as substrate measured immediately ...

Bioorg Med Chem Lett 27: 4622-4625 (2017)


Article DOI: 10.1016/j.bmcl.2017.09.023
BindingDB Entry DOI: 10.7270/Q2X069HQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%