Affinity Data by PubMed id=29077404

PubMed code 29077404

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50246439 (CHEMBL4082686) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50246436 (CHEMBL4090510) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM241949 (US9428466, Merbarone) Show SMILES O=C(Nc1ccccc1)C1C(=O)NC(=S)NC1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50246438 (CHEMBL4098224) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50127140 ((-)-etoposide \| (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50246426 (CHEMBL4062530) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50246437 (CHEMBL4100676) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%