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PubMed code 29313684

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270003
PNG
(CHEMBL4075458)
Show SMILES O=C1C=Cc2c(c(cn2S(=O)(=O)c2ccccc2)-c2ccccc2)C1=O |c:2|
Show InChI InChI=1S/C20H13NO4S/c22-18-12-11-17-19(20(18)23)16(14-7-3-1-4-8-14)13-21(17)26(24,25)15-9-5-2-6-10-15/h1-13H
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 13n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269995
PNG
(CHEMBL4064932)
Show SMILES COc1ccc(SC2=CC(=O)C(=O)c3c(cn(c23)S(=O)(=O)c2ccccc2)-c2ccccc2)cc1 |t:7|
Show InChI InChI=1S/C27H19NO5S2/c1-33-19-12-14-20(15-13-19)34-24-16-23(29)27(30)25-22(18-8-4-2-5-9-18)17-28(26(24)25)35(31,32)21-10-6-3-7-11-21/h2-17H,1H3
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 15n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269992
PNG
(CHEMBL4095060)
Show SMILES COc1ccc(cc1)C1=CC(=O)C(=O)c2c(cn(c12)S(=O)(=O)c1ccccc1)-c1ccccc1 |t:9|
Show InChI InChI=1S/C27H19NO5S/c1-33-20-14-12-19(13-15-20)22-16-24(29)27(30)25-23(18-8-4-2-5-9-18)17-28(26(22)25)34(31,32)21-10-6-3-7-11-21/h2-17H,1H3
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 41n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269999
PNG
(CHEMBL4100171)
Show SMILES Fc1ccc(cc1)S(=O)(=O)n1cc(c2c1C=CC(=O)C2=O)-c1ccccc1 |c:17|
Show InChI InChI=1S/C20H12FNO4S/c21-14-6-8-15(9-7-14)27(25,26)22-12-16(13-4-2-1-3-5-13)19-17(22)10-11-18(23)20(19)24/h1-12H
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 48n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50423877
PNG
(DIHYDROTANSHINONE | Dihydrotanshinone I | acs.jmed...)
Show SMILES C[C@H]1COC2=C1C(=O)C(=O)c1c2ccc2c(C)cccc12 |r,c:4|
Show InChI InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
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 50n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269991
PNG
(CHEMBL4105230)
Show SMILES COc1cccc(c1)C1=CC(=O)C(=O)c2c(cn(c12)S(=O)(=O)c1ccccc1)-c1ccccc1 |t:9|
Show InChI InChI=1S/C27H19NO5S/c1-33-20-12-8-11-19(15-20)22-16-24(29)27(30)25-23(18-9-4-2-5-10-18)17-28(26(22)25)34(31,32)21-13-6-3-7-14-21/h2-17H,1H3
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 55n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270012
PNG
(CHEMBL4073526)
Show SMILES CS(=O)(=O)n1cc(c2c1C=CC(=O)C2=O)-c1ccccc1 |c:10|
Show InChI InChI=1S/C15H11NO4S/c1-21(19,20)16-9-11(10-5-3-2-4-6-10)14-12(16)7-8-13(17)15(14)18/h2-9H,1H3
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 56n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269996
PNG
(CHEMBL4094161)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)n1cc(c2c1C=CC(=O)C2=O)-c1ccccc1 |c:20|
Show InChI InChI=1S/C22H16N2O5S/c1-14(25)23-16-7-9-17(10-8-16)30(28,29)24-13-18(15-5-3-2-4-6-15)21-19(24)11-12-20(26)22(21)27/h2-13H,1H3,(H,23,25)
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 81n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269994
PNG
(CHEMBL4102819)
Show SMILES O=C1C=C(c2c(c(cn2S(=O)(=O)c2ccccc2)-c2ccccc2)C1=O)c1ccccc1 |c:2|
Show InChI InChI=1S/C26H17NO4S/c28-23-16-21(18-10-4-1-5-11-18)25-24(26(23)29)22(19-12-6-2-7-13-19)17-27(25)32(30,31)20-14-8-3-9-15-20/h1-17H
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>100n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270007
PNG
(CHEMBL4067653)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1=CC(=O)C(=O)c2c(cn(c12)S(=O)(=O)c1ccccc1)-c1ccccc1 |t:10|
Show InChI InChI=1S/C26H16N2O6S/c29-23-15-21(18-11-13-19(14-12-18)28(31)32)25-24(26(23)30)22(17-7-3-1-4-8-17)16-27(25)35(33,34)20-9-5-2-6-10-20/h1-16H
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>100n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270014
PNG
(CHEMBL4076484)
Show SMILES CN(C)c1ccc(cc1)-c1cn(c2C=CC(=O)C(=O)c12)S(=O)(=O)c1ccccc1 |c:14|
Show InChI InChI=1S/C22H18N2O4S/c1-23(2)16-10-8-15(9-11-16)18-14-24(19-12-13-20(25)22(26)21(18)19)29(27,28)17-6-4-3-5-7-17/h3-14H,1-2H3
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>100n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270013
PNG
(CHEMBL4081086)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1cc(c2c1C=CC(=O)C2=O)-c1ccccc1 |c:19|
Show InChI InChI=1S/C20H12N2O6S/c23-18-10-9-17-19(20(18)24)16(13-5-2-1-3-6-13)12-21(17)29(27,28)15-8-4-7-14(11-15)22(25)26/h1-12H
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>100n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269997
PNG
(CHEMBL4092808)
Show SMILES Fc1cccc(c1)S(=O)(=O)n1cc(c2c1C=CC(=O)C2=O)-c1ccccc1 |c:17|
Show InChI InChI=1S/C20H12FNO4S/c21-14-7-4-8-15(11-14)27(25,26)22-12-16(13-5-2-1-3-6-13)19-17(22)9-10-18(23)20(19)24/h1-12H
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>100n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270002
PNG
(CHEMBL4077265)
Show SMILES COc1ccc(cc1)-c1cn(c2C=CC(=O)C(=O)c12)S(=O)(=O)c1ccccc1 |c:13|
Show InChI InChI=1S/C21H15NO5S/c1-27-15-9-7-14(8-10-15)17-13-22(18-11-12-19(23)21(24)20(17)18)28(25,26)16-5-3-2-4-6-16/h2-13H,1H3
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>200n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270001
PNG
(CHEMBL4075620)
Show SMILES COc1cccc(c1)-c1cn(c2C=CC(=O)C(=O)c12)S(=O)(=O)c1ccccc1 |c:13|
Show InChI InChI=1S/C21H15NO5S/c1-27-15-7-5-6-14(12-15)17-13-22(18-10-11-19(23)21(24)20(17)18)28(25,26)16-8-3-2-4-9-16/h2-13H,1H3
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>200n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50269990
PNG
(CHEMBL4070465)
Show SMILES CC1=CC(=O)C(=O)c2c(cn(c12)S(=O)(=O)c1ccccc1)-c1ccccc1 |t:1|
Show InChI InChI=1S/C21H15NO4S/c1-14-12-18(23)21(24)19-17(15-8-4-2-5-9-15)13-22(20(14)19)27(25,26)16-10-6-3-7-11-16/h2-13H,1H3
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>200n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270004
PNG
(CHEMBL4073683)
Show SMILES O=C1c2c(cn(c2C2=C(C3CCC2C=C3)C1=O)S(=O)(=O)c1ccccc1)-c1ccccc1 |c:15,t:8|
Show InChI InChI=1S/C26H19NO4S/c28-25-22-18-13-11-17(12-14-18)21(22)24-23(26(25)29)20(16-7-3-1-4-8-16)15-27(24)32(30,31)19-9-5-2-6-10-19/h1-11,13,15,17-18H,12,14H2
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>300n/an/an/an/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens (Human))		BDBM50270003
PNG
(CHEMBL4075458)
Show SMILES O=C1C=Cc2c(c(cn2S(=O)(=O)c2ccccc2)-c2ccccc2)C1=O |c:2|
Show InChI InChI=1S/C20H13NO4S/c22-18-12-11-17-19(20(18)23)16(14-7-3-1-4-8-14)13-21(17)26(24,25)15-9-5-2-6-10-15/h1-13H
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n/an/an/a 4.50E+3n/an/an/an/an/a



Institute of Molecular Science and Technology (ISTM)

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant HuR expressed in Escherichia coli Rosetta DH5alpha measured for 30 mins by DMR analysis

J Med Chem 61: 1483-1498 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01176
BindingDB Entry DOI: 10.7270/Q2Q81GKP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%