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PubMed code 29359565

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50262993
PNG
(CHEMBL4059711)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H24F2N4O3/c1-14(9-20(30)26-18-11-16(24)10-17(25)12-18)22(31)27-21-19-6-3-2-5-15(19)13-28-7-4-8-29(28)23(21)32/h2-3,5-6,10-12,14,21H,4,7-9,13H2,1H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263008
PNG
(CHEMBL255473)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C43H64N6O9/c1-27(2)19-34(46-40(53)36(21-29(5)6)48-42(55)57-25-31-15-11-9-12-16-31)38(51)44-23-33(50)24-45-39(52)35(20-28(3)4)47-41(54)37(22-30(7)8)49-43(56)58-26-32-17-13-10-14-18-32/h9-18,27-30,34-37H,19-26H2,1-8H3,(H,44,51)(H,45,52)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t34-,35-,36-,37-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50241259
PNG
((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)
Show SMILES C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O |r|
Show InChI InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50262979
PNG
(CHEMBL4077007)
Show SMILES C[C@H](CC(=O)Nc1ccccc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C24H28N4O3/c1-16-8-3-6-11-20(16)25-21(29)14-17(2)23(30)26-22-19-10-5-4-9-18(19)15-27-12-7-13-28(27)24(22)31/h3-6,8-11,17,22H,7,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263007
PNG
(CHEMBL4076827)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50263007
PNG
(CHEMBL4076827)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot method

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Similar to RIKEN cDNA 2010106G01 (Predicted)


(Rattus norvegicus)		BDBM50263004
PNG
(CHEMBL4069936)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of rat SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst staini...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50262968
PNG
(CHEMBL4064631)
Show SMILES C[C@H](CC(=O)Nc1cccc(C)c1)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C24H28N4O3/c1-16-7-5-9-19(13-16)25-21(29)14-17(2)23(30)26-22-20-10-4-3-8-18(20)15-27-11-6-12-28(27)24(22)31/h3-5,7-10,13,17,22H,6,11-12,14-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263010
PNG
(CHEMBL4100749)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2cccc(F)c2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H25F2N5O3/c1-13(9-20(31)27-19-10-15(24)11-26-14(19)2)22(32)28-21-16-5-3-6-18(25)17(16)12-29-7-4-8-30(29)23(21)33/h3,5-6,10-11,13,21H,4,7-9,12H2,1-2H3,(H,27,31)(H,28,32)/t13-,21+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263004
PNG
(CHEMBL4069936)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263004
PNG
(CHEMBL4069936)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50263007
PNG
(CHEMBL4076827)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50263010
PNG
(CHEMBL4100749)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2cccc(F)c2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H25F2N5O3/c1-13(9-20(31)27-19-10-15(24)11-26-14(19)2)22(32)28-21-16-5-3-6-18(25)17(16)12-29-7-4-8-30(29)23(21)33/h3,5-6,10-11,13,21H,4,7-9,12H2,1-2H3,(H,27,31)(H,28,32)/t13-,21+/m1/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50263004
PNG
(CHEMBL4069936)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50263004
PNG
(CHEMBL4069936)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of mouse SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263005
PNG
(CHEMBL4077336)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CCCN2C1=O |r|
Show InChI InChI=1S/C25H26FN5O4/c1-14-20(11-16(26)13-27-14)28-21(32)12-19(15-7-8-15)23(33)29-22-17-5-2-3-6-18(17)24(34)30-9-4-10-31(30)25(22)35/h2-3,5-6,11,13,15,19,22H,4,7-10,12H2,1H3,(H,28,32)(H,29,33)/t19-,22-/m0/s1
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The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50262979
PNG
(CHEMBL4077007)
Show SMILES C[C@H](CC(=O)Nc1ccccc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C24H28N4O3/c1-16-8-3-6-11-20(16)25-21(29)14-17(2)23(30)26-22-19-10-5-4-9-18(19)15-27-12-7-13-28(27)24(22)31/h3-6,8-11,17,22H,7,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
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n/an/a 370n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2B


(Homo sapiens)		BDBM50263004
PNG
(CHEMBL4069936)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1
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n/an/a 430n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2b expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50263005
PNG
(CHEMBL4077336)
Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CCCN2C1=O |r|
Show InChI InChI=1S/C25H26FN5O4/c1-14-20(11-16(26)13-27-14)28-21(32)12-19(15-7-8-15)23(33)29-22-17-5-2-3-6-18(17)24(34)30-9-4-10-31(30)25(22)35/h2-3,5-6,11,13,15,19,22H,4,7-10,12H2,1H3,(H,28,32)(H,29,33)/t19-,22-/m0/s1
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n/an/a 496n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Mus musculus)		BDBM50262979
PNG
(CHEMBL4077007)
Show SMILES C[C@H](CC(=O)Nc1ccccc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C24H28N4O3/c1-16-8-3-6-11-20(16)25-21(29)14-17(2)23(30)26-22-19-10-5-4-9-18(19)15-27-12-7-13-28(27)24(22)31/h3-6,8-11,17,22H,7,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
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n/an/a 550n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot method

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50263006
PNG
(CHEMBL4074838)
Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2C(=O)N2CCCN2C1=O |r|
Show InChI InChI=1S/C23H24FN5O4/c1-13(10-19(30)26-18-11-15(24)12-25-14(18)2)21(31)27-20-16-6-3-4-7-17(16)22(32)28-8-5-9-29(28)23(20)33/h3-4,6-7,11-13,20H,5,8-10H2,1-2H3,(H,26,30)(H,27,31)/t13-,20+/m1/s1
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n/an/a 870n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50262965
PNG
(CHEMBL4105093)
Show SMILES C[C@H](CC(=O)Nc1cccnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C23H27N5O3/c1-15(13-20(29)25-19-9-5-10-24-16(19)2)22(30)26-21-18-8-4-3-7-17(18)14-27-11-6-12-28(27)23(21)31/h3-5,7-10,15,21H,6,11-14H2,1-2H3,(H,25,29)(H,26,30)/t15-,21+/m1/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50262967
PNG
(CHEMBL4075787)
Show SMILES C[C@H](CC(=O)Nc1ccc(C)cc1)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C24H28N4O3/c1-16-8-10-19(11-9-16)25-21(29)14-17(2)23(30)26-22-20-7-4-3-6-18(20)15-27-12-5-13-28(27)24(22)31/h3-4,6-11,17,22H,5,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
Signal peptide peptidase-like 2A


(Homo sapiens)		BDBM50262966
PNG
(CHEMBL4086098)
Show SMILES C[C@H](CC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r|
Show InChI InChI=1S/C24H25F3N4O3/c1-15(13-20(32)28-19-10-5-4-9-18(19)24(25,26)27)22(33)29-21-17-8-3-2-7-16(17)14-30-11-6-12-31(30)23(21)34/h2-5,7-10,15,21H,6,11-14H2,1H3,(H,28,32)(H,29,33)/t15-,21+/m1/s1
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n/an/a 2.85E+3n/an/an/an/an/an/a



The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Curated by ChEMBL


Assay Description
Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...

J Med Chem 61: 865-880 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01371
BindingDB Entry DOI: 10.7270/Q2JM2D49
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%