BindingDB logo
myBDB logout

PubMed code 29859906

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carboxypeptidase B2


(Homo sapiens (Human))
BDBM50275212
PNG
(CHEMBL4127473)
Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Showa Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human plasma activated thrombin-activatable fibrinolysis inhibitor after 10 mins in presence of DTT


Bioorg Med Chem Lett 28: 2256-2260 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.042
BindingDB Entry DOI: 10.7270/Q25M686N
More data for this
Ligand-Target Pair
Carboxypeptidase B


(Sus scrofa)
BDBM50275212
PNG
(CHEMBL4127473)
Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Showa Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreas carboxypeptidase B after 10 mins in presence of DTT


Bioorg Med Chem Lett 28: 2256-2260 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.042
BindingDB Entry DOI: 10.7270/Q25M686N
More data for this
Ligand-Target Pair
Carboxypeptidase B


(Sus scrofa)
BDBM50275212
PNG
(CHEMBL4127473)
Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Showa Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreas carboxypeptidase B after 10 mins in absence of DTT


Bioorg Med Chem Lett 28: 2256-2260 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.042
BindingDB Entry DOI: 10.7270/Q25M686N
More data for this
Ligand-Target Pair
Carboxypeptidase B2


(Homo sapiens (Human))
BDBM50275212
PNG
(CHEMBL4127473)
Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.70E+5n/an/an/an/an/an/a



Showa Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human plasma activated thrombin-activatable fibrinolysis inhibitor after 10 mins in absence of DTT


Bioorg Med Chem Lett 28: 2256-2260 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.042
BindingDB Entry DOI: 10.7270/Q25M686N
More data for this
Ligand-Target Pair
Carboxypeptidase N catalytic chain


(Homo sapiens (Human))
BDBM50275212
PNG
(CHEMBL4127473)
Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>3.80E+5n/an/an/an/an/an/a



Showa Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N preincubated for 10 mins followed by hippuryl-lysine substrate addition measured after 30 mins in absence of D...


Bioorg Med Chem Lett 28: 2256-2260 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.042
BindingDB Entry DOI: 10.7270/Q25M686N
More data for this
Ligand-Target Pair
Carboxypeptidase N catalytic chain


(Homo sapiens (Human))
BDBM50275212
PNG
(CHEMBL4127473)
Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>3.80E+5n/an/an/an/an/an/a



Showa Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human carboxypeptidase N preincubated for 10 mins followed by hippuryl-lysine substrate addition measured after 30 mins in presence of ...


Bioorg Med Chem Lett 28: 2256-2260 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.042
BindingDB Entry DOI: 10.7270/Q25M686N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%