BindingDB logo
myBDB logout

PubMed code 6142952

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
PubMed
 20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
PubMed
 20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Aminopeptidase M from porcine kidney was determined and Ki was reported which is obta...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027041
PNG
(2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-met...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Show InChI InChI=1S/C13H26N2O4/c1-7(2)5-9(14)11(16)12(17)15-10(13(18)19)6-8(3)4/h7-11,16H,5-6,14H2,1-4H3,(H,15,17)(H,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027042
PNG
(3-Amino-2-hydroxy-5-methyl-hexanoic acid {2-methyl...)
Show SMILES CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](O)[C@@H](N)CC(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C22H44N4O4/c1-12(2)9-10-24-20(28)17(14(5)6)25-21(29)18(15(7)8)26-22(30)19(27)16(23)11-13(3)4/h12-19,27H,9-11,23H2,1-8H3,(H,24,28)(H,25,29)(H,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 180n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
MMDB
PubMed
 200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
MMDB
PubMed
 220n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027043
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-buty...)
Show SMILES CC(C)CCNC(=O)[C@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2O2/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 500n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase from porcine kidney and the inhibition constant was determined after preincubatin...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027042
PNG
(3-Amino-2-hydroxy-5-methyl-hexanoic acid {2-methyl...)
Show SMILES CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](O)[C@@H](N)CC(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C22H44N4O4/c1-12(2)9-10-24-20(28)17(14(5)6)25-21(29)18(15(7)8)26-22(30)19(27)16(23)11-13(3)4/h12-19,27H,9-11,23H2,1-8H3,(H,24,28)(H,25,29)(H,26,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 890n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027046
PNG
(2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-...)
Show SMILES CC(C)CC(N)C(O)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H29N3O7/c1-7(2)5-9(17)13(22)15(24)19-12(8(3)4)14(23)18-10(16(25)26)6-11(20)21/h7-10,12-13,22H,5-6,17H2,1-4H3,(H,18,23)(H,19,24)(H,20,21)(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 900n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027046
PNG
(2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-...)
Show SMILES CC(C)CC(N)C(O)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H29N3O7/c1-7(2)5-9(17)13(22)15(24)19-12(8(3)4)14(23)18-10(16(25)26)6-11(20)21/h7-10,12-13,22H,5-6,17H2,1-4H3,(H,18,23)(H,19,24)(H,20,21)(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 940n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against aminopeptidase M

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027046
PNG
(2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-...)
Show SMILES CC(C)CC(N)C(O)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H29N3O7/c1-7(2)5-9(17)13(22)15(24)19-12(8(3)4)14(23)18-10(16(25)26)6-11(20)21/h7-10,12-13,22H,5-6,17H2,1-4H3,(H,18,23)(H,19,24)(H,20,21)(H,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.24E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
PubMed
 2.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50367209
PNG
(BESTATIN HYDROCHLORIDE | Ubenimex)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
PDB
PubMed
 4.10E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50367209
PNG
(BESTATIN HYDROCHLORIDE | Ubenimex)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
PDB
PubMed
 4.10E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50367209
PNG
(BESTATIN HYDROCHLORIDE | Ubenimex)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
PDB
PubMed
 7.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027041
PNG
(2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-met...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Show InChI InChI=1S/C13H26N2O4/c1-7(2)5-9(14)11(16)12(17)15-10(13(18)19)6-8(3)4/h7-11,16H,5-6,14H2,1-4H3,(H,15,17)(H,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.18E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027043
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-buty...)
Show SMILES CC(C)CCNC(=O)[C@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2O2/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) from porcine kidney and the inhibition constant was determined after preincubati...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027043
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-buty...)
Show SMILES CC(C)CCNC(=O)[C@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2O2/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027043
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-buty...)
Show SMILES CC(C)CCNC(=O)[C@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2O2/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.63E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50046325
PNG
((S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyryla...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PubMed
 1.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Aminopeptidase M from porcine kidney was determined and the Ki was reported which is ...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
MMDB
PubMed
 2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50367209
PNG
(BESTATIN HYDROCHLORIDE | Ubenimex)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
PubMed
 2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
<2.30E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027040
PNG
(2-{2-[2-(3-Amino-5-methyl-hexanoylamino)-3-methyl-...)
Show SMILES CC(C)C[C@@H](N)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O7/c1-10(2)7-13(22)8-15(26)24-17(11(3)4)20(30)25-18(12(5)6)19(29)23-14(21(31)32)9-16(27)28/h10-14,17-18H,7-9,22H2,1-6H3,(H,23,29)(H,24,26)(H,25,30)(H,27,28)(H,31,32)/t13-,14+,17+,18+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 2.50E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 2.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against aminopeptidase M

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027046
PNG
(2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-...)
Show SMILES CC(C)CC(N)C(O)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H29N3O7/c1-7(2)5-9(17)13(22)15(24)19-12(8(3)4)14(23)18-10(16(25)26)6-11(20)21/h7-10,12-13,22H,5-6,17H2,1-4H3,(H,18,23)(H,19,24)(H,20,21)(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 4.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50046325
PNG
((S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyryla...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
PubMed
 2.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 2.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50046325
PNG
((S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyryla...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
PubMed
 5.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027040
PNG
(2-{2-[2-(3-Amino-5-methyl-hexanoylamino)-3-methyl-...)
Show SMILES CC(C)C[C@@H](N)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O7/c1-10(2)7-13(22)8-15(26)24-17(11(3)4)20(30)25-18(12(5)6)19(29)23-14(21(31)32)9-16(27)28/h10-14,17-18H,7-9,22H2,1-6H3,(H,23,29)(H,24,26)(H,25,30)(H,27,28)(H,31,32)/t13-,14+,17+,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 6.81E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027044
PNG
(2-{2-[2-(2-Hydroxy-5-methyl-hexanoylamino)-3-methy...)
Show SMILES Cl.CC(C)CCC(O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Show InChI InChI=1S/C21H37N3O8.ClH/c1-10(2)7-8-14(25)18(28)23-17(12(5)6)20(30)24-16(11(3)4)19(29)22-13(21(31)32)9-15(26)27;/h10-14,16-17,25H,7-9H2,1-6H3,(H,22,29)(H,23,28)(H,24,30)(H,26,27)(H,31,32);1H/t13-,14?,16-,17-;/m0./s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 7.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) from porcine kidney and the inhibition constant was determined after preincubati...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027044
PNG
(2-{2-[2-(2-Hydroxy-5-methyl-hexanoylamino)-3-methy...)
Show SMILES Cl.CC(C)CCC(O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Show InChI InChI=1S/C21H37N3O8.ClH/c1-10(2)7-8-14(25)18(28)23-17(12(5)6)20(30)24-16(11(3)4)19(29)22-13(21(31)32)9-15(26)27;/h10-14,16-17,25H,7-9H2,1-6H3,(H,22,29)(H,23,28)(H,24,30)(H,26,27)(H,31,32);1H/t13-,14?,16-,17-;/m0./s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 7.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase from porcine kidney and the inhibition constant was determined after preincubatin...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027047
PNG
(4-Amino-3-hydroxy-6-methyl-heptanoic acid {2-methy...)
Show SMILES CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C[C@H](O)[C@@H](N)CC(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C23H46N4O4/c1-13(2)9-10-25-22(30)20(15(5)6)27-23(31)21(16(7)8)26-19(29)12-18(28)17(24)11-14(3)4/h13-18,20-21,28H,9-12,24H2,1-8H3,(H,25,30)(H,26,29)(H,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase from porcine kidney and the inhibition constant was determined after preincubatin...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027047
PNG
(4-Amino-3-hydroxy-6-methyl-heptanoic acid {2-methy...)
Show SMILES CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C[C@H](O)[C@@H](N)CC(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C23H46N4O4/c1-13(2)9-10-25-22(30)20(15(5)6)27-23(31)21(16(7)8)26-19(29)12-18(28)17(24)11-14(3)4/h13-18,20-21,28H,9-12,24H2,1-8H3,(H,25,30)(H,26,29)(H,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) from porcine kidney and the inhibition constant was determined after preincubati...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027050
PNG
(2-[2-(2-tert-Butoxycarbonylamino-3-methyl-butyryla...)
Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Show InChI InChI=1S/C19H33N3O8/c1-9(2)13(15(25)20-11(17(27)28)8-12(23)24)21-16(26)14(10(3)4)22-18(29)30-19(5,6)7/h9-11,13-14H,8H2,1-7H3,(H,20,25)(H,21,26)(H,22,29)(H,23,24)(H,27,28)/t11-,13-,14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 1.40E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase from porcine kidney and the inhibition constant was determined after preincubatin...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
 2.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Homo sapiens (Human))		BDBM50027049
PNG
(2-(3-Amino-2-methyl-4-phenyl-butyrylamino)-4-methy...)
Show SMILES CC(C)CC(NC(=O)[C@H](C)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H26N2O3/c1-11(2)9-15(17(21)22)19-16(20)12(3)14(18)10-13-7-5-4-6-8-13/h4-8,11-12,14-15H,9-10,18H2,1-3H3,(H,19,20)(H,21,22)/t12-,14+,15?/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 3.78E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and Ki* was reported which is obtained by the e...

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50367209
PNG
(BESTATIN HYDROCHLORIDE | Ubenimex)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
PDB
PubMed
n/an/a 3.03E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against aminopeptidase M

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50027045
PNG
(2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)...)
Show SMILES CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13-,15-,16-,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1

J Med Chem 27: 417-22 (1984)


BindingDB Entry DOI: 10.7270/Q280535G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%