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PubMed code 7535362

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Substance-P receptor


(Homo sapiens (Human))		BDBM50030435
PNG
(CHEMBL420543 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCCN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F6N3O3/c30-28(31,32)21-14-19(15-22(17-21)29(33,34)35)7-8-26(39)25(16-20-18-36-24-5-2-1-4-23(20)24)37-27(40)6-3-9-38-10-12-41-13-11-38/h1-2,4-5,14-15,17-18,25,36H,3,6-13,16H2,(H,37,40)/t25-/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030435
PNG
(CHEMBL420543 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCCN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F6N3O3/c30-28(31,32)21-14-19(15-22(17-21)29(33,34)35)7-8-26(39)25(16-20-18-36-24-5-2-1-4-23(20)24)37-27(40)6-3-9-38-10-12-41-13-11-38/h1-2,4-5,14-15,17-18,25,36H,3,6-13,16H2,(H,37,40)/t25-/m0/s1
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n/an/a 0.240n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030431
PNG
(CHEMBL176500 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCCN2CCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F6N3O2/c30-28(31,32)21-14-19(15-22(17-21)29(33,34)35)9-10-26(39)25(16-20-18-36-24-7-2-1-6-23(20)24)37-27(40)8-5-13-38-11-3-4-12-38/h1-2,6-7,14-15,17-18,25,36H,3-5,8-13,16H2,(H,37,40)/t25-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030438
PNG
(CHEMBL426577 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCC2CCNCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F6N3O2/c30-28(31,32)21-13-19(14-22(16-21)29(33,34)35)5-7-26(39)25(15-20-17-37-24-4-2-1-3-23(20)24)38-27(40)8-6-18-9-11-36-12-10-18/h1-4,13-14,16-18,25,36-37H,5-12,15H2,(H,38,40)/t25-/m0/s1
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n/an/a 0.370n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030429
PNG
(CHEMBL173396 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Cc2ccncc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23F6N3O2/c29-27(30,31)20-11-18(12-21(15-20)28(32,33)34)5-6-25(38)24(37-26(39)13-17-7-9-35-10-8-17)14-19-16-36-23-4-2-1-3-22(19)23/h1-4,7-12,15-16,24,36H,5-6,13-14H2,(H,37,39)/t24-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50000040
PNG
(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Show SMILES COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 |wD:10.10,17.20,(11.79,-2.71,;10.31,-3.13,;9.22,-2.04,;10.55,-1.27,;10.57,.27,;9.22,1.04,;7.89,.27,;7.89,-1.26,;6.56,-2.01,;6.56,-3.55,;5.21,-4.32,;3.92,-3.55,;3.16,-4.88,;4.65,-5.3,;3.88,-6.63,;2.57,-5.86,;2.57,-4.32,;5.21,-5.86,;6.56,-6.63,;6.54,-8.17,;5.21,-8.94,;5.21,-10.48,;6.54,-11.25,;7.89,-10.48,;7.87,-8.94,;7.89,-5.86,;9.22,-6.63,;10.55,-5.88,;10.55,-4.34,;9.22,-3.55,;7.89,-4.34,)|
Show InChI InChI=1S/C28H32N2O/c1-31-25-15-9-8-14-24(25)20-29-27-23-16-18-30(19-17-23)28(27)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-29H,16-20H2,1H3/t27-,28-/m0/s1
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n/an/a 0.450n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030439
PNG
(CHEMBL175224 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCc2ccncc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H25F6N3O2/c30-28(31,32)21-13-19(14-22(16-21)29(33,34)35)5-7-26(39)25(15-20-17-37-24-4-2-1-3-23(20)24)38-27(40)8-6-18-9-11-36-12-10-18/h1-4,9-14,16-17,25,37H,5-8,15H2,(H,38,40)/t25-/m0/s1
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n/an/a 0.470n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50000041
PNG
((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Show SMILES COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3/t17-,19-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Substance-P receptor


(Homo sapiens (Human))		BDBM50030429
PNG
(CHEMBL173396 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Cc2ccncc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23F6N3O2/c29-27(30,31)20-11-18(12-21(15-20)28(32,33)34)5-6-25(38)24(37-26(39)13-17-7-9-35-10-8-17)14-19-16-36-23-4-2-1-3-22(19)23/h1-4,7-12,15-16,24,36H,5-6,13-14H2,(H,37,39)/t24-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50000040
PNG
(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Show SMILES COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 |wD:10.10,17.20,(11.79,-2.71,;10.31,-3.13,;9.22,-2.04,;10.55,-1.27,;10.57,.27,;9.22,1.04,;7.89,.27,;7.89,-1.26,;6.56,-2.01,;6.56,-3.55,;5.21,-4.32,;3.92,-3.55,;3.16,-4.88,;4.65,-5.3,;3.88,-6.63,;2.57,-5.86,;2.57,-4.32,;5.21,-5.86,;6.56,-6.63,;6.54,-8.17,;5.21,-8.94,;5.21,-10.48,;6.54,-11.25,;7.89,-10.48,;7.87,-8.94,;7.89,-5.86,;9.22,-6.63,;10.55,-5.88,;10.55,-4.34,;9.22,-3.55,;7.89,-4.34,)|
Show InChI InChI=1S/C28H32N2O/c1-31-25-15-9-8-14-24(25)20-29-27-23-16-18-30(19-17-23)28(27)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-29H,16-20H2,1H3/t27-,28-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030444
PNG
(CHEMBL174016 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCN2CCCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F6N3O2/c30-28(31,32)21-14-19(15-22(17-21)29(33,34)35)8-9-26(39)25(16-20-18-36-24-7-3-2-6-23(20)24)37-27(40)10-13-38-11-4-1-5-12-38/h2-3,6-7,14-15,17-18,25,36H,1,4-5,8-13,16H2,(H,37,40)/t25-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030434
PNG
(5-Dimethylamino-pentanoic acid [(S)-4-(3,5-bis-tri...)
Show SMILES CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H31F6N3O2/c1-37(2)12-6-5-9-26(39)36-24(15-19-17-35-23-8-4-3-7-22(19)23)25(38)11-10-18-13-20(27(29,30)31)16-21(14-18)28(32,33)34/h3-4,7-8,13-14,16-17,24,35H,5-6,9-12,15H2,1-2H3,(H,36,39)/t24-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030440
PNG
(CHEMBL366818 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H29F6N3O2/c1-36(2)11-5-8-25(38)35-23(14-18-16-34-22-7-4-3-6-21(18)22)24(37)10-9-17-12-19(26(28,29)30)15-20(13-17)27(31,32)33/h3-4,6-7,12-13,15-16,23,34H,5,8-11,14H2,1-2H3,(H,35,38)/t23-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030433
PNG
(1-Aza-bicyclo[2.2.2]octane-4-carboxylic acid [(S)-...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C23CCN(CC2)CC3)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H29F6N3O2/c30-28(31,32)20-13-18(14-21(16-20)29(33,34)35)5-6-25(39)24(15-19-17-36-23-4-2-1-3-22(19)23)37-26(40)27-7-10-38(11-8-27)12-9-27/h1-4,13-14,16-17,24,36H,5-12,15H2,(H,37,40)/t24-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030433
PNG
(1-Aza-bicyclo[2.2.2]octane-4-carboxylic acid [(S)-...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C23CCN(CC2)CC3)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H29F6N3O2/c30-28(31,32)20-13-18(14-21(16-20)29(33,34)35)5-6-25(39)24(15-19-17-36-23-4-2-1-3-22(19)23)37-26(40)27-7-10-38(11-8-27)12-9-27/h1-4,13-14,16-17,24,36H,5-12,15H2,(H,37,40)/t24-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030435
PNG
(CHEMBL420543 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCCN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F6N3O3/c30-28(31,32)21-14-19(15-22(17-21)29(33,34)35)7-8-26(39)25(16-20-18-36-24-5-2-1-4-23(20)24)37-27(40)6-3-9-38-10-12-41-13-11-38/h1-2,4-5,14-15,17-18,25,36H,3,6-13,16H2,(H,37,40)/t25-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM21016
PNG
(CHEMBL22870 | L 732138 | L-732,138 | L732138 | N-a...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030445
PNG
(CHEMBL174526 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H27F6N3O2/c1-35(2)10-9-24(37)34-22(13-17-15-33-21-6-4-3-5-20(17)21)23(36)8-7-16-11-18(25(27,28)29)14-19(12-16)26(30,31)32/h3-6,11-12,14-15,22,33H,7-10,13H2,1-2H3,(H,34,37)/t22-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030441
PNG
(CHEMBL173231 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H27F6N3O3/c28-26(29,30)19-11-17(12-20(14-19)27(31,32)33)5-6-24(37)23(35-25(38)16-36-7-9-39-10-8-36)13-18-15-34-22-4-2-1-3-21(18)22/h1-4,11-12,14-15,23,34H,5-10,13,16H2,(H,35,38)/t23-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030442
PNG
(CHEMBL120781 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H20F6N2O2/c1-13(32)31-20(10-15-12-30-19-5-3-2-4-18(15)19)21(33)7-6-14-8-16(22(24,25)26)11-17(9-14)23(27,28)29/h2-5,8-9,11-12,20,30H,6-7,10H2,1H3,(H,31,32)/t20-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030442
PNG
(CHEMBL120781 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H20F6N2O2/c1-13(32)31-20(10-15-12-30-19-5-3-2-4-18(15)19)21(33)7-6-14-8-16(22(24,25)26)11-17(9-14)23(27,28)29/h2-5,8-9,11-12,20,30H,6-7,10H2,1H3,(H,31,32)/t20-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM21016
PNG
(CHEMBL22870 | L 732138 | L-732,138 | L732138 | N-a...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030441
PNG
(CHEMBL173231 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H27F6N3O3/c28-26(29,30)19-11-17(12-20(14-19)27(31,32)33)5-6-24(37)23(35-25(38)16-36-7-9-39-10-8-36)13-18-15-34-22-4-2-1-3-21(18)22/h1-4,11-12,14-15,23,34H,5-10,13,16H2,(H,35,38)/t23-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030443
PNG
(CHEMBL173564 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Cc2cnc[nH]2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H22F6N4O2/c27-25(28,29)17-7-15(8-18(10-17)26(30,31)32)5-6-23(37)22(36-24(38)11-19-13-33-14-35-19)9-16-12-34-21-4-2-1-3-20(16)21/h1-4,7-8,10,12-14,22,34H,5-6,9,11H2,(H,33,35)(H,36,38)/t22-/m0/s1
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n/an/a 3.80n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030441
PNG
(CHEMBL173231 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCOCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H27F6N3O3/c28-26(29,30)19-11-17(12-20(14-19)27(31,32)33)5-6-24(37)23(35-25(38)16-36-7-9-39-10-8-36)13-18-15-34-22-4-2-1-3-21(18)22/h1-4,11-12,14-15,23,34H,5-10,13,16H2,(H,35,38)/t23-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030430
PNG
(CHEMBL369601 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H25F6N3O2/c1-34(2)14-23(36)33-21(11-16-13-32-20-6-4-3-5-19(16)20)22(35)8-7-15-9-17(24(26,27)28)12-18(10-15)25(29,30)31/h3-6,9-10,12-13,21,32H,7-8,11,14H2,1-2H3,(H,33,36)/t21-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030433
PNG
(1-Aza-bicyclo[2.2.2]octane-4-carboxylic acid [(S)-...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C23CCN(CC2)CC3)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H29F6N3O2/c30-28(31,32)20-13-18(14-21(16-20)29(33,34)35)5-6-25(39)24(15-19-17-36-23-4-2-1-3-22(19)23)37-26(40)27-7-10-38(11-8-27)12-9-27/h1-4,13-14,16-17,24,36H,5-12,15H2,(H,37,40)/t24-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM21016
PNG
(CHEMBL22870 | L 732138 | L-732,138 | L732138 | N-a...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
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n/an/a 8.10n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030429
PNG
(CHEMBL173396 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Cc2ccncc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23F6N3O2/c29-27(30,31)20-11-18(12-21(15-20)28(32,33)34)5-6-25(38)24(37-26(39)13-17-7-9-35-10-8-17)14-19-16-36-23-4-2-1-3-22(19)23/h1-4,7-12,15-16,24,36H,5-6,13-14H2,(H,37,39)/t24-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030442
PNG
(CHEMBL120781 | N-[(S)-4-(3,5-Bis-trifluoromethyl-p...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H20F6N2O2/c1-13(32)31-20(10-15-12-30-19-5-3-2-4-18(15)19)21(33)7-6-14-8-16(22(24,25)26)11-17(9-14)23(27,28)29/h2-5,8-9,11-12,20,30H,6-7,10H2,1H3,(H,31,32)/t20-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030127
PNG
((S)-2-Benzoylamino-3-(1H-indol-3-yl)-propionic aci...)
Show SMILES Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C27H26N2O3/c1-18-12-19(2)14-20(13-18)17-32-27(31)25(29-26(30)21-8-4-3-5-9-21)15-22-16-28-24-11-7-6-10-23(22)24/h3-14,16,25,28H,15,17H2,1-2H3,(H,29,30)/t25-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50000040
PNG
(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Show SMILES COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 |wD:10.10,17.20,(11.79,-2.71,;10.31,-3.13,;9.22,-2.04,;10.55,-1.27,;10.57,.27,;9.22,1.04,;7.89,.27,;7.89,-1.26,;6.56,-2.01,;6.56,-3.55,;5.21,-4.32,;3.92,-3.55,;3.16,-4.88,;4.65,-5.3,;3.88,-6.63,;2.57,-5.86,;2.57,-4.32,;5.21,-5.86,;6.56,-6.63,;6.54,-8.17,;5.21,-8.94,;5.21,-10.48,;6.54,-11.25,;7.89,-10.48,;7.87,-8.94,;7.89,-5.86,;9.22,-6.63,;10.55,-5.88,;10.55,-4.34,;9.22,-3.55,;7.89,-4.34,)|
Show InChI InChI=1S/C28H32N2O/c1-31-25-15-9-8-14-24(25)20-29-27-23-16-18-30(19-17-23)28(27)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-29H,16-20H2,1H3/t27-,28-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030437
PNG
((2S,3S)-2-Benzhydryl-3-(3-trifluoromethyl-benzylox...)
Show SMILES FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 |wD:18.20,11.10,(12.92,-3.55,;12.92,-2.01,;14.25,-1.24,;11.83,-3.1,;11.59,-1.24,;11.59,.31,;10.24,1.08,;8.91,.3,;8.94,-1.23,;7.59,-2,;7.59,-3.54,;6.26,-4.32,;4.93,-3.55,;3.6,-4.32,;3.6,-5.86,;4.93,-6.63,;5.7,-5.3,;4.21,-4.89,;6.26,-5.85,;7.59,-6.61,;8.94,-5.85,;10.27,-6.61,;11.59,-5.85,;11.59,-4.3,;10.24,-3.54,;8.94,-4.32,;7.61,-8.16,;6.28,-8.94,;6.28,-10.47,;7.61,-11.25,;8.94,-10.47,;8.94,-8.92,;10.25,-2,)|
Show InChI InChI=1S/C28H28F3NO/c29-28(30,31)24-13-7-8-20(18-24)19-33-27-23-14-16-32(17-15-23)26(27)25(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-13,18,23,25-27H,14-17,19H2/t26-,27-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030437
PNG
((2S,3S)-2-Benzhydryl-3-(3-trifluoromethyl-benzylox...)
Show SMILES FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 |wD:18.20,11.10,(12.92,-3.55,;12.92,-2.01,;14.25,-1.24,;11.83,-3.1,;11.59,-1.24,;11.59,.31,;10.24,1.08,;8.91,.3,;8.94,-1.23,;7.59,-2,;7.59,-3.54,;6.26,-4.32,;4.93,-3.55,;3.6,-4.32,;3.6,-5.86,;4.93,-6.63,;5.7,-5.3,;4.21,-4.89,;6.26,-5.85,;7.59,-6.61,;8.94,-5.85,;10.27,-6.61,;11.59,-5.85,;11.59,-4.3,;10.24,-3.54,;8.94,-4.32,;7.61,-8.16,;6.28,-8.94,;6.28,-10.47,;7.61,-11.25,;8.94,-10.47,;8.94,-8.92,;10.25,-2,)|
Show InChI InChI=1S/C28H28F3NO/c29-28(30,31)24-13-7-8-20(18-24)19-33-27-23-14-16-32(17-15-23)26(27)25(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-13,18,23,25-27H,14-17,19H2/t26-,27-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030133
PNG
((S)-2-Acetylamino-3-(1H-indol-3-yl)-propionic acid...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1
Show InChI InChI=1S/C22H24N2O3/c1-14-8-15(2)10-17(9-14)13-27-22(26)21(24-16(3)25)11-18-12-23-20-7-5-4-6-19(18)20/h4-10,12,21,23H,11,13H2,1-3H3,(H,24,25)/t21-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030446
PNG
(CHEMBL176557 | N-[(S)-1-(3,5-Dimethyl-benzyloxymet...)
Show SMILES CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H26N2O2/c1-15-8-16(2)10-18(9-15)13-26-14-20(24-17(3)25)11-19-12-23-22-7-5-4-6-21(19)22/h4-10,12,20,23H,11,13-14H2,1-3H3,(H,24,25)/t20-/m0/s1
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n/an/a 767n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030432
PNG
(CHEMBL305608 | N-[(S)-1-[(3,5-Dimethyl-benzyl)-met...)
Show SMILES CN(Cc1cc(C)cc(C)c1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H29N3O2/c1-19-13-20(2)15-21(14-19)18-31(3)28(33)26(30-27(32)22-9-5-4-6-10-22)16-23-17-29-25-12-8-7-11-24(23)25/h4-15,17,26,29H,16,18H2,1-3H3,(H,30,32)/t26-/m0/s1
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n/an/a 1.03E+3n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030436
PNG
(CHEMBL332796 | N-[(S)-1-(3,5-Dimethyl-benzylcarbam...)
Show SMILES Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C27H27N3O2/c1-18-12-19(2)14-20(13-18)16-29-27(32)25(30-26(31)21-8-4-3-5-9-21)15-22-17-28-24-11-7-6-10-23(22)24/h3-14,17,25,28H,15-16H2,1-2H3,(H,29,32)(H,30,31)/t25-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50030437
PNG
((2S,3S)-2-Benzhydryl-3-(3-trifluoromethyl-benzylox...)
Show SMILES FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 |wD:18.20,11.10,(12.92,-3.55,;12.92,-2.01,;14.25,-1.24,;11.83,-3.1,;11.59,-1.24,;11.59,.31,;10.24,1.08,;8.91,.3,;8.94,-1.23,;7.59,-2,;7.59,-3.54,;6.26,-4.32,;4.93,-3.55,;3.6,-4.32,;3.6,-5.86,;4.93,-6.63,;5.7,-5.3,;4.21,-4.89,;6.26,-5.85,;7.59,-6.61,;8.94,-5.85,;10.27,-6.61,;11.59,-5.85,;11.59,-4.3,;10.24,-3.54,;8.94,-4.32,;7.61,-8.16,;6.28,-8.94,;6.28,-10.47,;7.61,-11.25,;8.94,-10.47,;8.94,-8.92,;10.25,-2,)|
Show InChI InChI=1S/C28H28F3NO/c29-28(30,31)24-13-7-8-20(18-24)19-33-27-23-14-16-32(17-15-23)26(27)25(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-13,18,23,25-27H,14-17,19H2/t26-,27-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr...

J Med Chem 38: 934-41 (1995)


BindingDB Entry DOI: 10.7270/Q2R78D8F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%