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PubMed code 7562908

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3309
PNG
(4-N-(3-bromophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3cccc(Br)c3)c2cn1
Show InChI InChI=1S/C13H10BrN5/c14-8-2-1-3-9(4-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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PubMed
n/an/a 10n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3312
PNG
(4-N-[3-(trifluoromethyl)phenyl]pyrido[4,3-d]pyrimi...)
Show SMILES Nc1cc2ncnc(Nc3cccc(c3)C(F)(F)F)c2cn1
Show InChI InChI=1S/C14H10F3N5/c15-14(16,17)8-2-1-3-9(4-8)22-13-10-6-19-12(18)5-11(10)20-7-21-13/h1-7H,(H2,18,19)(H,20,21,22)
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PubMed
n/an/a 15n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3327
PNG
(4-N-(3-methylphenyl)pyrido[4,3-d]pyrimidine-4,7-di...)
Show SMILES Cc1cccc(Nc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C14H13N5/c1-9-3-2-4-10(5-9)19-14-11-7-16-13(15)6-12(11)17-8-18-14/h2-8H,1H3,(H2,15,16)(H,17,18,19)
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n/an/a 40n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3306
PNG
(4-N-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3cccc(c3)[N+]([O-])=O)c2cn1
Show InChI InChI=1S/C13H10N6O2/c14-12-5-11-10(6-15-12)13(17-7-16-11)18-8-2-1-3-9(4-8)19(20)21/h1-7H,(H2,14,15)(H,16,17,18)
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n/an/a 40n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3326
PNG
(3-({7-aminopyrido[4,3-d]pyrimidin-4-yl}amino)pheno...)
Show SMILES Nc1cc2ncnc(Nc3cccc(O)c3)c2cn1
Show InChI InChI=1S/C13H11N5O/c14-12-5-11-10(6-15-12)13(17-7-16-11)18-8-2-1-3-9(19)4-8/h1-7,19H,(H2,14,15)(H,16,17,18)
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n/an/a 70n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3310
PNG
(4-N-(4-bromophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3ccc(Br)cc3)c2cn1
Show InChI InChI=1S/C13H10BrN5/c14-8-1-3-9(4-2-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 90n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3324
PNG
(4-N-(3-chlorophenyl)pyrido[4,3-d]pyrimidine-4,7-di...)
Show SMILES Nc1cc2ncnc(Nc3cccc(Cl)c3)c2cn1
Show InChI InChI=1S/C13H10ClN5/c14-8-2-1-3-9(4-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 120n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3315
PNG
(4-N-(3-methoxyphenyl)pyrido[4,3-d]pyrimidine-4,7-d...)
Show SMILES COc1cccc(Nc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C14H13N5O/c1-20-10-4-2-3-9(5-10)19-14-11-7-16-13(15)6-12(11)17-8-18-14/h2-8H,1H3,(H2,15,16)(H,17,18,19)
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n/an/a 130n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3344
PNG
(4-N-[(2-aminophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3ccccc3N)c2cn1
Show InChI InChI=1S/C14H14N6/c15-11-4-2-1-3-9(11)6-18-14-10-7-17-13(16)5-12(10)19-8-20-14/h1-5,7-8H,6,15H2,(H2,16,17)(H,18,19,20)
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n/an/a 230n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3308
PNG
(4-N-(2-bromophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3ccccc3Br)c2cn1
Show InChI InChI=1S/C13H10BrN5/c14-9-3-1-2-4-10(9)19-13-8-6-16-12(15)5-11(8)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 240n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3304
PNG
(4-N-phenylpyrido[4,3-d]pyrimidine-4,7-diamine | 7-...)
Show SMILES Nc1cc2ncnc(Nc3ccccc3)c2cn1
Show InChI InChI=1S/C13H11N5/c14-12-6-11-10(7-15-12)13(17-8-16-11)18-9-4-2-1-3-5-9/h1-8H,(H2,14,15)(H,16,17,18)
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n/an/a 250n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3325
PNG
(4-N-(3-iodophenyl)pyrido[4,3-d]pyrimidine-4,7-diam...)
Show SMILES Nc1cc2ncnc(Nc3cccc(I)c3)c2cn1
Show InChI InChI=1S/C13H10IN5/c14-8-2-1-3-9(4-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 260n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3331
PNG
(4-N-benzylpyrido[4,3-d]pyrimidine-4,7-diamine | 7-...)
Show SMILES Nc1cc2ncnc(NCc3ccccc3)c2cn1
Show InChI InChI=1S/C14H13N5/c15-13-6-12-11(8-16-13)14(19-9-18-12)17-7-10-4-2-1-3-5-10/h1-6,8-9H,7H2,(H2,15,16)(H,17,18,19)
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n/an/a 580n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3316
PNG
(4-N-(4-methoxyphenyl)pyrido[4,3-d]pyrimidine-4,7-d...)
Show SMILES COc1ccc(Nc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C14H13N5O/c1-20-10-4-2-9(3-5-10)19-14-11-7-16-13(15)6-12(11)17-8-18-14/h2-8H,1H3,(H2,15,16)(H,17,18,19)
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n/an/a 670n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3323
PNG
(4-N-(3-fluorophenyl)pyrido[4,3-d]pyrimidine-4,7-di...)
Show SMILES Nc1cc2ncnc(Nc3cccc(F)c3)c2cn1
Show InChI InChI=1S/C13H10FN5/c14-8-2-1-3-9(4-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 840n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3336
PNG
(4-N-[(3-bromophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3cccc(Br)c3)c2cn1
Show InChI InChI=1S/C14H12BrN5/c15-10-3-1-2-9(4-10)6-18-14-11-7-17-13(16)5-12(11)19-8-20-14/h1-5,7-8H,6H2,(H2,16,17)(H,18,19,20)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3305
PNG
(4-N-(2-nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3ccccc3[N+]([O-])=O)c2cn1
Show InChI InChI=1S/C13H10N6O2/c14-12-5-10-8(6-15-12)13(17-7-16-10)18-9-3-1-2-4-11(9)19(20)21/h1-7H,(H2,14,15)(H,16,17,18)
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n/an/a 1.25E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3318
PNG
(4-N-(3-aminophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cccc(Nc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C13H12N6/c14-8-2-1-3-9(4-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,14H2,(H2,15,16)(H,17,18,19)
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n/an/a 1.55E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3335
PNG
(4-N-[(2-bromophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3ccccc3Br)c2cn1
Show InChI InChI=1S/C14H12BrN5/c15-11-4-2-1-3-9(11)6-18-14-10-7-17-13(16)5-12(10)19-8-20-14/h1-5,7-8H,6H2,(H2,16,17)(H,18,19,20)
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n/an/a 1.67E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3321
PNG
(4-N-[3-(dimethylamino)phenyl]pyrido[4,3-d]pyrimidi...)
Show SMILES CN(C)c1cccc(Nc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C15H16N6/c1-21(2)11-5-3-4-10(6-11)20-15-12-8-17-14(16)7-13(12)18-9-19-15/h3-9H,1-2H3,(H2,16,17)(H,18,19,20)
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n/an/a 1.79E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3339
PNG
(4-N-{[3-(trifluoromethyl)phenyl]methyl}pyrido[4,3-...)
Show SMILES Nc1cc2ncnc(NCc3cccc(c3)C(F)(F)F)c2cn1
Show InChI InChI=1S/C15H12F3N5/c16-15(17,18)10-3-1-2-9(4-10)6-21-14-11-7-20-13(19)5-12(11)22-8-23-14/h1-5,7-8H,6H2,(H2,19,20)(H,21,22,23)
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n/an/a 1.95E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3337
PNG
(4-N-[(4-bromophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3ccc(Br)cc3)c2cn1
Show InChI InChI=1S/C14H12BrN5/c15-10-3-1-9(2-4-10)6-18-14-11-7-17-13(16)5-12(11)19-8-20-14/h1-5,7-8H,6H2,(H2,16,17)(H,18,19,20)
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n/an/a 2.46E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3342
PNG
(4-N-[(3-methoxyphenyl)methyl]pyrido[4,3-d]pyrimidi...)
Show SMILES COc1cccc(CNc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C15H15N5O/c1-21-11-4-2-3-10(5-11)7-18-15-12-8-17-14(16)6-13(12)19-9-20-15/h2-6,8-9H,7H2,1H3,(H2,16,17)(H,18,19,20)
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n/an/a 2.87E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3314
PNG
(4-N-(2-methoxyphenyl)pyrido[4,3-d]pyrimidine-4,7-d...)
Show SMILES COc1ccccc1Nc1ncnc2cc(N)ncc12
Show InChI InChI=1S/C14H13N5O/c1-20-12-5-3-2-4-10(12)19-14-9-7-16-13(15)6-11(9)17-8-18-14/h2-8H,1H3,(H2,15,16)(H,17,18,19)
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n/an/a 3.71E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3332
PNG
(4-N-[(2-nitrophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3ccccc3[N+]([O-])=O)c2cn1
Show InChI InChI=1S/C14H12N6O2/c15-13-5-11-10(7-16-13)14(19-8-18-11)17-6-9-3-1-2-4-12(9)20(21)22/h1-5,7-8H,6H2,(H2,15,16)(H,17,18,19)
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n/an/a 4.25E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3313
PNG
(4-N-[4-(trifluoromethyl)phenyl]pyrido[4,3-d]pyrimi...)
Show SMILES Nc1cc2ncnc(Nc3ccc(cc3)C(F)(F)F)c2cn1
Show InChI InChI=1S/C14H10F3N5/c15-14(16,17)8-1-3-9(4-2-8)22-13-10-6-19-12(18)5-11(10)20-7-21-13/h1-7H,(H2,18,19)(H,20,21,22)
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n/an/a 4.70E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3322
PNG
(4-N-[4-(dimethylamino)phenyl]pyrido[4,3-d]pyrimidi...)
Show SMILES CN(C)c1ccc(Nc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C15H16N6/c1-21(2)11-5-3-10(4-6-11)20-15-12-8-17-14(16)7-13(12)18-9-19-15/h3-9H,1-2H3,(H2,16,17)(H,18,19,20)
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n/an/a 4.86E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3317
PNG
(4-N-(2-aminophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3ccccc3N)c2cn1
Show InChI InChI=1S/C13H12N6/c14-9-3-1-2-4-10(9)19-13-8-6-16-12(15)5-11(8)17-7-18-13/h1-7H,14H2,(H2,15,16)(H,17,18,19)
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n/an/a 5.25E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3319
PNG
(4-N-(4-aminophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1ccc(Nc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C13H12N6/c14-8-1-3-9(4-2-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,14H2,(H2,15,16)(H,17,18,19)
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n/an/a 5.90E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3340
PNG
(4-N-{[4-(trifluoromethyl)phenyl]methyl}pyrido[4,3-...)
Show SMILES Nc1cc2ncnc(NCc3ccc(cc3)C(F)(F)F)c2cn1
Show InChI InChI=1S/C15H12F3N5/c16-15(17,18)10-3-1-9(2-4-10)6-21-14-11-7-20-13(19)5-12(11)22-8-23-14/h1-5,7-8H,6H2,(H2,19,20)(H,21,22,23)
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3338
PNG
(4-N-{[2-(trifluoromethyl)phenyl]methyl}pyrido[4,3-...)
Show SMILES Nc1cc2ncnc(NCc3ccccc3C(F)(F)F)c2cn1
Show InChI InChI=1S/C15H12F3N5/c16-15(17,18)11-4-2-1-3-9(11)6-21-14-10-7-20-13(19)5-12(10)22-8-23-14/h1-5,7-8H,6H2,(H2,19,20)(H,21,22,23)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3330
PNG
(7-Aminopyrido[4,3-d]pyrimidine 7aa | 7-amino-4-[(4...)
Show SMILES CC(=O)Nc1ccc(Nc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C15H14N6O/c1-9(22)20-10-2-4-11(5-3-10)21-15-12-7-17-14(16)6-13(12)18-8-19-15/h2-8H,1H3,(H2,16,17)(H,20,22)(H,18,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3348
PNG
(4-N-{[3-(dimethylamino)phenyl]methyl}pyrido[4,3-d]...)
Show SMILES CN(C)c1cccc(CNc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C16H18N6/c1-22(2)12-5-3-4-11(6-12)8-19-16-13-9-18-15(17)7-14(13)20-10-21-16/h3-7,9-10H,8H2,1-2H3,(H2,17,18)(H,19,20,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3346
PNG
(4-N-[(4-aminophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1ccc(CNc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C14H14N6/c15-10-3-1-9(2-4-10)6-18-14-11-7-17-13(16)5-12(11)19-8-20-14/h1-5,7-8H,6,15H2,(H2,16,17)(H,18,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3329
PNG
(7-Aminopyrido[4,3-d]pyrimidine 7z | 7-amino-4-[(3-...)
Show SMILES CC(=O)Nc1cccc(Nc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C15H14N6O/c1-9(22)20-10-3-2-4-11(5-10)21-15-12-7-17-14(16)6-13(12)18-8-19-15/h2-8H,1H3,(H2,16,17)(H,20,22)(H,18,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3311
PNG
(4-N-[2-(trifluoromethyl)phenyl]pyrido[4,3-d]pyrimi...)
Show SMILES Nc1cc2ncnc(Nc3ccccc3C(F)(F)F)c2cn1
Show InChI InChI=1S/C14H10F3N5/c15-14(16,17)9-3-1-2-4-10(9)22-13-8-6-19-12(18)5-11(8)20-7-21-13/h1-7H,(H2,18,19)(H,20,21,22)
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n/an/a 1.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3345
PNG
(4-N-[(3-aminophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cccc(CNc2ncnc3cc(N)ncc23)c1
Show InChI InChI=1S/C14H14N6/c15-10-3-1-2-9(4-10)6-18-14-11-7-17-13(16)5-12(11)19-8-20-14/h1-5,7-8H,6,15H2,(H2,16,17)(H,18,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3328
PNG
(4-N-(pyridin-3-yl)pyrido[4,3-d]pyrimidine-4,7-diam...)
Show SMILES Nc1cc2ncnc(Nc3cccnc3)c2cn1
Show InChI InChI=1S/C12H10N6/c13-11-4-10-9(6-15-11)12(17-7-16-10)18-8-2-1-3-14-5-8/h1-7H,(H2,13,15)(H,16,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3334
PNG
(4-N-[(4-nitrophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3ccc(cc3)[N+]([O-])=O)c2cn1
Show InChI InChI=1S/C14H12N6O2/c15-13-5-12-11(7-16-13)14(19-8-18-12)17-6-9-1-3-10(4-2-9)20(21)22/h1-5,7-8H,6H2,(H2,15,16)(H,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3333
PNG
(4-N-[(3-nitrophenyl)methyl]pyrido[4,3-d]pyrimidine...)
Show SMILES Nc1cc2ncnc(NCc3cccc(c3)[N+]([O-])=O)c2cn1
Show InChI InChI=1S/C14H12N6O2/c15-13-5-12-11(7-16-13)14(19-8-18-12)17-6-9-2-1-3-10(4-9)20(21)22/h1-5,7-8H,6H2,(H2,15,16)(H,17,18,19)
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n/an/a 1.01E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3307
PNG
(4-N-(4-nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-dia...)
Show SMILES Nc1cc2ncnc(Nc3ccc(cc3)[N+]([O-])=O)c2cn1
Show InChI InChI=1S/C13H10N6O2/c14-12-5-11-10(6-15-12)13(17-7-16-11)18-8-1-3-9(4-2-8)19(20)21/h1-7H,(H2,14,15)(H,16,17,18)
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n/an/a 6.50E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3320
PNG
(4-N-[2-(dimethylamino)phenyl]pyrido[4,3-d]pyrimidi...)
Show SMILES CN(C)c1ccccc1Nc1ncnc2cc(N)ncc12
Show InChI InChI=1S/C15H16N6/c1-21(2)13-6-4-3-5-11(13)20-15-10-8-17-14(16)7-12(10)18-9-19-15/h3-9H,1-2H3,(H2,16,17)(H,18,19,20)
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n/an/a 6.90E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3343
PNG
(4-N-[(4-methoxyphenyl)methyl]pyrido[4,3-d]pyrimidi...)
Show SMILES COc1ccc(CNc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C15H15N5O/c1-21-11-4-2-10(3-5-11)7-18-15-12-8-17-14(16)6-13(12)19-9-20-15/h2-6,8-9H,7H2,1H3,(H2,16,17)(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3347
PNG
(4-N-{[2-(dimethylamino)phenyl]methyl}pyrido[4,3-d]...)
Show SMILES CN(C)c1ccccc1CNc1ncnc2cc(N)ncc12
Show InChI InChI=1S/C16H18N6/c1-22(2)14-6-4-3-5-11(14)8-19-16-12-9-18-15(17)7-13(12)20-10-21-16/h3-7,9-10H,8H2,1-2H3,(H2,17,18)(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3341
PNG
(4-N-[(2-methoxyphenyl)methyl]pyrido[4,3-d]pyrimidi...)
Show SMILES COc1ccccc1CNc1ncnc2cc(N)ncc12
Show InChI InChI=1S/C15H15N5O/c1-21-13-5-3-2-4-10(13)7-18-15-11-8-17-14(16)6-12(11)19-9-20-15/h2-6,8-9H,7H2,1H3,(H2,16,17)(H,18,19,20)
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3349
PNG
(4-N-{[4-(dimethylamino)phenyl]methyl}pyrido[4,3-d]...)
Show SMILES CN(C)c1ccc(CNc2ncnc3cc(N)ncc23)cc1
Show InChI InChI=1S/C16H18N6/c1-22(2)12-5-3-11(4-6-12)8-19-16-13-9-18-15(17)7-14(13)20-10-21-16/h3-7,9-10H,8H2,1-2H3,(H2,17,18)(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3780-8 (1995)


Article DOI: 10.1021/jm00019a007
BindingDB Entry DOI: 10.7270/Q2Z899M8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%