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PubMed code 7699710

Compile data set for download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 0.320n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033843
PNG
(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3/b19-8+
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n/an/a 0.350n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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n/an/a 0.360n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033851
PNG
(1-(2-Methoxy-phenyl)-4-[3-(1,2,3,4-tetrahydro-naph...)
Show SMILES COc1ccccc1N1CCN(CCCC2CCCc3ccccc23)CC1
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,12-14,21H,6-7,9-11,15-19H2,1H3
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n/an/a 0.390n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50008735
PNG
((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Show SMILES CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34
Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033833
PNG
(1-{3-[5-Methoxy-3,4-dihydro-2H-naphthalen-(1E)-yli...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H32N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,9-10,12-14H,5,7-8,11,15-19H2,1-2H3/b20-9+
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n/an/a 0.520n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033836
PNG
(1-(2-Methoxy-phenyl)-4-[2-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCc12)SCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H32N2O2S/c1-27-22-11-5-8-20-19(22)7-6-12-24(20)29-18-17-25-13-15-26(16-14-25)21-9-3-4-10-23(21)28-2/h3-5,8-11,24H,6-7,12-18H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033859
PNG
(1-(2-Methoxy-phenyl)-4-[3-(4,5,6,7-tetrahydro-benz...)
Show SMILES COc1ccccc1N1CCN(CCCC2CCCc3ccsc23)CC1
Show InChI InChI=1S/C22H30N2OS/c1-25-21-10-3-2-9-20(21)24-15-13-23(14-16-24)12-5-8-18-6-4-7-19-11-17-26-22(18)19/h2-3,9-11,17-18H,4-8,12-16H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033853
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)=CCCc12 |c:24|
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,7,9,11-13H,4,6,8,10,14-18H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033831
PNG
(1-[4-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-butyl...)
Show SMILES COc1ccc2CCC=C(CCCCN3CCN(CC3)c3ccccc3OC)c2c1 |t:8|
Show InChI InChI=1S/C26H34N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,9,11-14,20H,5-8,10,15-19H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033844
PNG
(1-{3-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-prop...)
Show SMILES COc1ccccc1N1CCN(CC\C=C2/CCCc3ccccc23)CC1
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,11-14H,6-7,9-10,15-19H2,1H3/b21-11+
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Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033834
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccc3OC)c2c1 |t:8|
Show InChI InChI=1S/C25H32N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,7,10-13,19H,5-6,8-9,14-18H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033841
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccn3)c2c1
Show InChI InChI=1S/C23H31N3O/c1-27-21-11-10-20-7-4-6-19(22(20)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,9-12,18-19H,4-8,13-17H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 5.64n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033849
PNG
(1-(2-Methoxy-phenyl)-4-[2-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(SCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C24H32N2O2S/c1-27-20-11-10-19-6-5-9-24(21(19)18-20)29-17-16-25-12-14-26(15-13-25)22-7-3-4-8-23(22)28-2/h3-4,7-8,10-11,18,24H,5-6,9,12-17H2,1-2H3
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n/an/a 5.94n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033847
PNG
(CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033836
PNG
(1-(2-Methoxy-phenyl)-4-[2-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCc12)SCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H32N2O2S/c1-27-22-11-5-8-20-19(22)7-6-12-24(20)29-18-17-25-13-15-26(16-14-25)21-9-3-4-10-23(21)28-2/h3-5,8-11,24H,6-7,12-18H2,1-2H3
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n/an/a 7.83n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033838
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)=CCCc12 |c:26|
Show InChI InChI=1S/C25H32N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,8,10,12-14H,5,7,9,11,15-19H2,1-2H3
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n/an/a 8.80n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033842
PNG
(1-(2-Methoxy-phenyl)-4-[4-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C26H36N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,11-14,20-21H,5-10,15-19H2,1-2H3
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n/an/a 8.83n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033854
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3)c2c1
Show InChI InChI=1S/C24H32N2O/c1-27-23-13-12-21-8-5-7-20(24(21)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,10-13,19-20H,5-9,14-18H2,1H3
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n/an/a 9.24n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033859
PNG
(1-(2-Methoxy-phenyl)-4-[3-(4,5,6,7-tetrahydro-benz...)
Show SMILES COc1ccccc1N1CCN(CCCC2CCCc3ccsc23)CC1
Show InChI InChI=1S/C22H30N2OS/c1-25-21-10-3-2-9-20(21)24-15-13-23(14-16-24)12-5-8-18-6-4-7-19-11-17-26-22(18)19/h2-3,9-11,17-18H,4-8,12-16H2,1H3
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antibodypedia
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n/an/a 9.70n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033831
PNG
(1-[4-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-butyl...)
Show SMILES COc1ccc2CCC=C(CCCCN3CCN(CC3)c3ccccc3OC)c2c1 |t:8|
Show InChI InChI=1S/C26H34N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,9,11-14,20H,5-8,10,15-19H2,1-2H3
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n/an/a 10.6n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033833
PNG
(1-{3-[5-Methoxy-3,4-dihydro-2H-naphthalen-(1E)-yli...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H32N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,9-10,12-14H,5,7-8,11,15-19H2,1-2H3/b20-9+
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n/an/a 11.3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033844
PNG
(1-{3-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-prop...)
Show SMILES COc1ccccc1N1CCN(CC\C=C2/CCCc3ccccc23)CC1
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,11-14H,6-7,9-10,15-19H2,1H3/b21-11+
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n/an/a 12.7n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 12.8n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033848
PNG
(1-[4-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-butyl...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)=CCCc12 |c:27|
Show InChI InChI=1S/C26H34N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,10-11,13-15H,5-7,9,12,16-20H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 15.4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033838
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)=CCCc12 |c:26|
Show InChI InChI=1S/C25H32N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,8,10,12-14H,5,7,9,11,15-19H2,1-2H3
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n/an/a 17.4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033850
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)=CCCc12 |c:24|
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,8,10-12,14H,5,7,9,13,15-19H2,1H3
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n/an/a 18.3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033859
PNG
(1-(2-Methoxy-phenyl)-4-[3-(4,5,6,7-tetrahydro-benz...)
Show SMILES COc1ccccc1N1CCN(CCCC2CCCc3ccsc23)CC1
Show InChI InChI=1S/C22H30N2OS/c1-25-21-10-3-2-9-20(21)24-15-13-23(14-16-24)12-5-8-18-6-4-7-19-11-17-26-22(18)19/h2-3,9-11,17-18H,4-8,12-16H2,1H3
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n/an/a 24.1n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033851
PNG
(1-(2-Methoxy-phenyl)-4-[3-(1,2,3,4-tetrahydro-naph...)
Show SMILES COc1ccccc1N1CCN(CCCC2CCCc3ccccc23)CC1
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,12-14,21H,6-7,9-11,15-19H2,1H3
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n/an/a 24.7n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033854
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3)c2c1
Show InChI InChI=1S/C24H32N2O/c1-27-23-13-12-21-8-5-7-20(24(21)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,10-13,19-20H,5-9,14-18H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033838
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)=CCCc12 |c:26|
Show InChI InChI=1S/C25H32N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,8,10,12-14H,5,7,9,11,15-19H2,1-2H3
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n/an/a 33n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033846
PNG
(CHEMBL425134 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1ccc2CCCC(NCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C24H33N3O2/c1-28-20-11-10-19-6-5-7-22(21(19)18-20)25-12-13-26-14-16-27(17-15-26)23-8-3-4-9-24(23)29-2/h3-4,8-11,18,22,25H,5-7,12-17H2,1-2H3
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n/an/a 40.3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033849
PNG
(1-(2-Methoxy-phenyl)-4-[2-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(SCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C24H32N2O2S/c1-27-20-11-10-19-6-5-9-24(21(19)18-20)29-17-16-25-12-14-26(15-13-25)22-7-3-4-8-23(22)28-2/h3-4,7-8,10-11,18,24H,5-6,9,12-17H2,1-2H3
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n/an/a 50.2n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033842
PNG
(1-(2-Methoxy-phenyl)-4-[4-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C26H36N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,11-14,20-21H,5-10,15-19H2,1-2H3
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n/an/a 50.9n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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n/an/a 51.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033853
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)=CCCc12 |c:24|
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,7,9,11-13H,4,6,8,10,14-18H2,1H3
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n/an/a 52n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033833
PNG
(1-{3-[5-Methoxy-3,4-dihydro-2H-naphthalen-(1E)-yli...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H32N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,9-10,12-14H,5,7-8,11,15-19H2,1-2H3/b20-9+
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n/an/a 52.2n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033831
PNG
(1-[4-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-butyl...)
Show SMILES COc1ccc2CCC=C(CCCCN3CCN(CC3)c3ccccc3OC)c2c1 |t:8|
Show InChI InChI=1S/C26H34N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,9,11-14,20H,5-8,10,15-19H2,1-2H3
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n/an/a 53.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033850
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)=CCCc12 |c:24|
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,8,10-12,14H,5,7,9,13,15-19H2,1H3
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n/an/a 54.4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033844
PNG
(1-{3-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-prop...)
Show SMILES COc1ccccc1N1CCN(CC\C=C2/CCCc3ccccc23)CC1
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-5-4-13-23(24)26-18-16-25(17-19-26)15-7-11-21-10-6-9-20-8-2-3-12-22(20)21/h2-5,8,11-14H,6-7,9-10,15-19H2,1H3/b21-11+
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n/an/a 55n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033837
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc12 |c:28|
Show InChI InChI=1S/C25H29F3N2O/c1-31-24-12-4-10-22-19(6-2-11-23(22)24)7-5-13-29-14-16-30(17-15-29)21-9-3-8-20(18-21)25(26,27)28/h3-4,6,8-10,12,18H,2,5,7,11,13-17H2,1H3
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n/an/a 55.9n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 59.9n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033856
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccn3)c2c1 |t:8|
Show InChI InChI=1S/C23H29N3O/c1-27-21-11-10-20-7-4-6-19(22(20)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,6,9-12,18H,4-5,7-8,13-17H2,1H3
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n/an/a 63.6n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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n/an/a 64.1n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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n/an/a 67.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033832
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C25H31F3N2O/c1-31-23-11-10-20-6-2-5-19(24(20)18-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(17-22)25(26,27)28/h3,8-11,17-19H,2,4-7,12-16H2,1H3
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n/an/a 87.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033832
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C25H31F3N2O/c1-31-23-11-10-20-6-2-5-19(24(20)18-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(17-22)25(26,27)28/h3,8-11,17-19H,2,4-7,12-16H2,1H3
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n/an/a 88.4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033834
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccc3OC)c2c1 |t:8|
Show InChI InChI=1S/C25H32N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,7,10-13,19H,5-6,8-9,14-18H2,1-2H3
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n/an/a 90.6n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033842
PNG
(1-(2-Methoxy-phenyl)-4-[4-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C26H36N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,11-14,20-21H,5-10,15-19H2,1-2H3
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n/an/a 92.8n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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n/an/a 96.7n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033843
PNG
(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3/b19-8+
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n/an/a 99.1n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033853
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)=CCCc12 |c:24|
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,7,9,11-13H,4,6,8,10,14-18H2,1H3
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n/an/a 119n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033841
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccn3)c2c1
Show InChI InChI=1S/C23H31N3O/c1-27-21-11-10-20-7-4-6-19(22(20)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,9-12,18-19H,4-8,13-17H2,1H3
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n/an/a 125n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033849
PNG
(1-(2-Methoxy-phenyl)-4-[2-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(SCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C24H32N2O2S/c1-27-20-11-10-19-6-5-9-24(21(19)18-20)29-17-16-25-12-14-26(15-13-25)22-7-3-4-8-23(22)28-2/h3-4,7-8,10-11,18,24H,5-6,9,12-17H2,1-2H3
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n/an/a 138n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033840
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c2c1 |t:8|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-11-10-20-6-2-5-19(24(20)18-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(17-22)25(26,27)28/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
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n/an/a 138n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033855
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)CCCc12
Show InChI InChI=1S/C25H31F3N2O/c1-31-24-12-4-10-22-19(6-2-11-23(22)24)7-5-13-29-14-16-30(17-15-29)21-9-3-8-20(18-21)25(26,27)28/h3-4,8-10,12,18-19H,2,5-7,11,13-17H2,1H3
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n/an/a 146n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50033845
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccc3)c2c1 |t:8|
Show InChI InChI=1S/C24H30N2O/c1-27-23-13-12-21-8-5-7-20(24(21)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,7,10-13,19H,5-6,8-9,14-18H2,1H3
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n/an/a 147n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033843
PNG
(1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...)
Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3/b19-8+
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033847
PNG
(CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3
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n/an/a 151n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033845
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccc3)c2c1 |t:8|
Show InChI InChI=1S/C24H30N2O/c1-27-23-13-12-21-8-5-7-20(24(21)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,7,10-13,19H,5-6,8-9,14-18H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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n/an/a 177n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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n/an/a 198n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 226n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033834
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccc3OC)c2c1 |t:8|
Show InChI InChI=1S/C25H32N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,7,10-13,19H,5-6,8-9,14-18H2,1-2H3
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n/an/a 228n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033856
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccn3)c2c1 |t:8|
Show InChI InChI=1S/C23H29N3O/c1-27-21-11-10-20-7-4-6-19(22(20)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,6,9-12,18H,4-5,7-8,13-17H2,1H3
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n/an/a 246n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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n/an/a 263n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033850
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)=CCCc12 |c:24|
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,8,10-12,14H,5,7,9,13,15-19H2,1H3
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n/an/a 303n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033841
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccn3)c2c1
Show InChI InChI=1S/C23H31N3O/c1-27-21-11-10-20-7-4-6-19(22(20)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,9-12,18-19H,4-8,13-17H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033855
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)CCCc12
Show InChI InChI=1S/C25H31F3N2O/c1-31-24-12-4-10-22-19(6-2-11-23(22)24)7-5-13-29-14-16-30(17-15-29)21-9-3-8-20(18-21)25(26,27)28/h3-4,8-10,12,18-19H,2,5-7,11,13-17H2,1H3
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n/an/a 472n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033847
PNG
(CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3
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n/an/a 618n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033837
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)=CCCc12 |c:28|
Show InChI InChI=1S/C25H29F3N2O/c1-31-24-12-4-10-22-19(6-2-11-23(22)24)7-5-13-29-14-16-30(17-15-29)21-9-3-8-20(18-21)25(26,27)28/h3-4,6,8-10,12,18H,2,5,7,11,13-17H2,1H3
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n/an/a 644n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033845
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccc3)c2c1 |t:8|
Show InChI InChI=1S/C24H30N2O/c1-27-23-13-12-21-8-5-7-20(24(21)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,7,10-13,19H,5-6,8-9,14-18H2,1H3
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Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033856
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3ccccn3)c2c1 |t:8|
Show InChI InChI=1S/C23H29N3O/c1-27-21-11-10-20-7-4-6-19(22(20)18-21)8-5-13-25-14-16-26(17-15-25)23-9-2-3-12-24-23/h2-3,6,9-12,18H,4-5,7-8,13-17H2,1H3
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n/an/a 778n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033846
PNG
(CHEMBL425134 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1ccc2CCCC(NCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C24H33N3O2/c1-28-20-11-10-19-6-5-7-22(21(19)18-20)25-12-13-26-14-16-27(17-15-26)23-8-3-4-9-24(23)29-2/h3-4,8-11,18,22,25H,5-7,12-17H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
The compound was evaluated for the binding affinity towards Dopamine receptor D2 binding site using [3H]-spiroperidol.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033840
PNG
(1-[3-(7-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1ccc2CCC=C(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c2c1 |t:8|
Show InChI InChI=1S/C25H29F3N2O/c1-31-23-11-10-20-6-2-5-19(24(20)18-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(17-22)25(26,27)28/h3,5,8-11,17-18H,2,4,6-7,12-16H2,1H3
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n/an/a 1.29E+3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033832
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C25H31F3N2O/c1-31-23-11-10-20-6-2-5-19(24(20)18-23)7-4-12-29-13-15-30(16-14-29)22-9-3-8-21(17-22)25(26,27)28/h3,8-11,17-19H,2,4-7,12-16H2,1H3
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n/an/a 1.33E+3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50033848
PNG
(1-[4-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-butyl...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)=CCCc12 |c:27|
Show InChI InChI=1S/C26H34N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,10-11,13-15H,5-7,9,12,16-20H2,1-2H3
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n/an/a 5.92E+3n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%