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PubMed code 8064792

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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 14n/an/an/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of PDGF-stimulated autophosphorylation of PDGF-receptor

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039650
PNG
(6,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL280...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-15-8-12-7-13(11-3-5-17-6-4-11)10-18-14(12)9-16(15)20-2/h3-10H,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039654
PNG
(7-Chloro-3-pyridin-4-yl-quinoline | CHEMBL86664)
Show SMILES Clc1ccc2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C14H9ClN2/c15-13-2-1-11-7-12(9-17-14(11)8-13)10-3-5-16-6-4-10/h1-9H
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n/an/a 300n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039659
PNG
(6-Methoxy-3-pyridin-4-yl-quinoline | CHEMBL90780)
Show SMILES COc1ccc2ncc(cc2c1)-c1ccncc1
Show InChI InChI=1S/C15H12N2O/c1-18-14-2-3-15-12(9-14)8-13(10-17-15)11-4-6-16-7-5-11/h2-10H,1H3
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n/an/a 400n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039649
PNG
(5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline | CHEMBL...)
Show SMILES COc1cc2ncc(cc2c(OC)c1OC)-c1ccncc1
Show InChI InChI=1S/C17H16N2O3/c1-20-15-9-14-13(16(21-2)17(15)22-3)8-12(10-19-14)11-4-6-18-7-5-11/h4-10H,1-3H3
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n/an/a 400n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039660
PNG
(7-Methoxy-3-pyridin-4-yl-quinoline | CHEMBL329622)
Show SMILES COc1ccc2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C15H12N2O/c1-18-14-3-2-12-8-13(10-17-15(12)9-14)11-4-6-16-7-5-11/h2-10H,1H3
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n/an/a 600n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039652
PNG
(3-Pyridin-4-yl-quinoline-5,7-diol | CHEMBL87083)
Show SMILES Oc1cc(O)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C14H10N2O2/c17-11-6-13-12(14(18)7-11)5-10(8-16-13)9-1-3-15-4-2-9/h1-8,17-18H
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039658
PNG
(3-Pyridin-4-yl-quinoline | CHEMBL89550)
Show SMILES c1ccc2ncc(cc2c1)-c1ccncc1
Show InChI InChI=1S/C14H10N2/c1-2-4-14-12(3-1)9-13(10-16-14)11-5-7-15-8-6-11/h1-10H
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n/an/a 1.50E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50039651
PNG
(3-Pyridin-4-yl-quinoline-6,7-diol | CHEMBL87084)
Show SMILES Oc1cc2cc(cnc2cc1O)-c1ccncc1
Show InChI InChI=1S/C14H10N2O2/c17-13-6-10-5-11(9-1-3-15-4-2-9)8-16-12(10)7-14(13)18/h1-8,17-18H
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039656
PNG
(3-Pyridin-4-yl-quinolin-7-ol | CHEMBL314811)
Show SMILES Oc1ccc2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C14H10N2O/c17-13-2-1-11-7-12(9-16-14(11)8-13)10-3-5-15-6-4-10/h1-9,17H
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n/an/a 9.20E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of p56 lck kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50039651
PNG
(3-Pyridin-4-yl-quinoline-6,7-diol | CHEMBL87084)
Show SMILES Oc1cc2cc(cnc2cc1O)-c1ccncc1
Show InChI InChI=1S/C14H10N2O2/c17-13-6-10-5-11(9-1-3-15-4-2-9)8-16-12(10)7-14(13)18/h1-8,17-18H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of p56 lck kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50039650
PNG
(6,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL280...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-15-8-12-7-13(11-3-5-17-6-4-11)10-18-14(12)9-16(15)20-2/h3-10H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of p56 lck kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50039651
PNG
(3-Pyridin-4-yl-quinoline-6,7-diol | CHEMBL87084)
Show SMILES Oc1cc2cc(cnc2cc1O)-c1ccncc1
Show InChI InChI=1S/C14H10N2O2/c17-13-6-10-5-11(9-1-3-15-4-2-9)8-16-12(10)7-14(13)18/h1-8,17-18H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of erbB2 receptor

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50039654
PNG
(7-Chloro-3-pyridin-4-yl-quinoline | CHEMBL86664)
Show SMILES Clc1ccc2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C14H9ClN2/c15-13-2-1-11-7-12(9-17-14(11)8-13)10-3-5-16-6-4-10/h1-9H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of erbB2 receptor

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of erbB2 receptor

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50039654
PNG
(7-Chloro-3-pyridin-4-yl-quinoline | CHEMBL86664)
Show SMILES Clc1ccc2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C14H9ClN2/c15-13-2-1-11-7-12(9-17-14(11)8-13)10-3-5-16-6-4-10/h1-9H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50039650
PNG
(6,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL280...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-15-8-12-7-13(11-3-5-17-6-4-11)10-18-14(12)9-16(15)20-2/h3-10H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of erbB2 receptor

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50039654
PNG
(7-Chloro-3-pyridin-4-yl-quinoline | CHEMBL86664)
Show SMILES Clc1ccc2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C14H9ClN2/c15-13-2-1-11-7-12(9-17-14(11)8-13)10-3-5-16-6-4-10/h1-9H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of p56 lck kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50039650
PNG
(6,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL280...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-15-8-12-7-13(11-3-5-17-6-4-11)10-18-14(12)9-16(15)20-2/h3-10H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039651
PNG
(3-Pyridin-4-yl-quinoline-6,7-diol | CHEMBL87084)
Show SMILES Oc1cc2cc(cnc2cc1O)-c1ccncc1
Show InChI InChI=1S/C14H10N2O2/c17-13-6-10-5-11(9-1-3-15-4-2-9)8-16-12(10)7-14(13)18/h1-8,17-18H
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n/an/a 3.60E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039653
PNG
(6-Methoxy-4-methyl-3-pyridin-4-yl-quinoline | CHEM...)
Show SMILES COc1ccc2ncc(-c3ccncc3)c(C)c2c1
Show InChI InChI=1S/C16H14N2O/c1-11-14-9-13(19-2)3-4-16(14)18-10-15(11)12-5-7-17-8-6-12/h3-10H,1-2H3
PDB

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n/an/a>5.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50039657
PNG
(7-Methoxy-4-methyl-3-pyridin-4-yl-quinoline | CHEM...)
Show SMILES COc1ccc2c(C)c(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O/c1-11-14-4-3-13(19-2)9-16(14)18-10-15(11)12-5-7-17-8-6-12/h3-10H,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor tyrosine kinase

J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%