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PubMed code 8389876

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045092
PNG
(5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1
Show InChI InChI=1S/C30H28O8/c1-36-21-10-7-19(8-11-21)6-4-2-3-5-17-37-25-15-12-23-28(33)24-18-20(30(34)35)9-14-26(24)38-29(23)22(25)13-16-27(31)32/h4,6-12,14-15,18H,2-3,5,13,16-17H2,1H3,(H,31,32)(H,34,35)/b6-4+
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 5.90n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition constant against binding of [3H]-LTB4 to human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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n/an/a 1.90n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-LTB4 to receptor on nonradioactive LTB4

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045092
PNG
(5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1
Show InChI InChI=1S/C30H28O8/c1-36-21-10-7-19(8-11-21)6-4-2-3-5-17-37-25-15-12-23-28(33)24-18-20(30(34)35)9-14-26(24)38-29(23)22(25)13-16-27(31)32/h4,6-12,14-15,18H,2-3,5,13,16-17H2,1H3,(H,31,32)(H,34,35)/b6-4+
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n/an/a 6.20n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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n/an/a 13n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [3H]-LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045091
PNG
(5-(2-Carboxy-ethyl)-6-decyloxy-9-oxo-9H-xanthene-2...)
Show SMILES CCCCCCCCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O
Show InChI InChI=1S/C27H32O7/c1-2-3-4-5-6-7-8-9-16-33-22-14-11-20-25(30)21-17-18(27(31)32)10-13-23(21)34-26(20)19(22)12-15-24(28)29/h10-11,13-14,17H,2-9,12,15-16H2,1H3,(H,28,29)(H,31,32)
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n/an/a 43n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045092
PNG
(5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1
Show InChI InChI=1S/C30H28O8/c1-36-21-10-7-19(8-11-21)6-4-2-3-5-17-37-25-15-12-23-28(33)24-18-20(30(34)35)9-14-26(24)38-29(23)22(25)13-16-27(31)32/h4,6-12,14-15,18H,2-3,5,13,16-17H2,1H3,(H,31,32)(H,34,35)/b6-4+
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n/an/a 133n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045096
PNG
(3-[3-(2-Carboxy-ethyl)-4-decyloxy-benzoyl]-benzoic...)
Show SMILES CCCCCCCCCCOc1ccc(cc1CCC(O)=O)C(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C27H34O6/c1-2-3-4-5-6-7-8-9-17-33-24-15-13-22(18-20(24)14-16-25(28)29)26(30)21-11-10-12-23(19-21)27(31)32/h10-13,15,18-19H,2-9,14,16-17H2,1H3,(H,28,29)(H,31,32)
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n/an/a 210n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045091
PNG
(5-(2-Carboxy-ethyl)-6-decyloxy-9-oxo-9H-xanthene-2...)
Show SMILES CCCCCCCCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O
Show InChI InChI=1S/C27H32O7/c1-2-3-4-5-6-7-8-9-16-33-22-14-11-20-25(30)21-17-18(27(31)32)10-13-23(21)34-26(20)19(22)12-15-24(28)29/h10-11,13-14,17H,2-9,12,15-16H2,1H3,(H,28,29)(H,31,32)
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n/an/a 513n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045093
PNG
(7-(2-Carboxy-ethyl)-6-decyloxy-9-oxo-9H-xanthene-2...)
Show SMILES CCCCCCCCCCOc1cc2oc3ccc(cc3c(=O)c2cc1CCC(O)=O)C(O)=O
Show InChI InChI=1S/C27H32O7/c1-2-3-4-5-6-7-8-9-14-33-23-17-24-21(15-18(23)11-13-25(28)29)26(30)20-16-19(27(31)32)10-12-22(20)34-24/h10,12,15-17H,2-9,11,13-14H2,1H3,(H,28,29)(H,31,32)
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n/an/a 832n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045094
PNG
(7-(2-Carboxy-ethyl)-6-decyloxy-9-oxo-9H-xanthene-4...)
Show SMILES CCCCCCCCCCOc1cc2oc3c(cccc3c(=O)c2cc1CCC(O)=O)C(O)=O
Show InChI InChI=1S/C27H32O7/c1-2-3-4-5-6-7-8-9-15-33-22-17-23-21(16-18(22)13-14-24(28)29)25(30)19-11-10-12-20(27(31)32)26(19)34-23/h10-12,16-17H,2-9,13-15H2,1H3,(H,28,29)(H,31,32)
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n/an/a 1.77E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045095
PNG
(5-(2-Carboxy-ethyl)-6-decyloxy-9-oxo-9H-xanthene-4...)
Show SMILES CCCCCCCCCCOc1ccc2c(oc3c(cccc3c2=O)C(O)=O)c1CCC(O)=O
Show InChI InChI=1S/C27H32O7/c1-2-3-4-5-6-7-8-9-17-33-22-15-13-20-24(30)19-11-10-12-21(27(31)32)26(19)34-25(20)18(22)14-16-23(28)29/h10-13,15H,2-9,14,16-17H2,1H3,(H,28,29)(H,31,32)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%