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PubMed code 9438025

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062142
PNG
(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Show SMILES CC1CC(C)N=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-5-3-6(2)9-7(8)4-5/h5-6H,3-4H2,1-2H3,(H2,8,9)
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PubMed
n/an/a 60n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062142
PNG
(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Show SMILES CC1CC(C)N=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-5-3-6(2)9-7(8)4-5/h5-6H,3-4H2,1-2H3,(H2,8,9)
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PubMed
n/an/a 80n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062133
PNG
(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Show SMILES CC1CCN=C(N)C1 |t:4|
Show InChI InChI=1S/C6H12N2/c1-5-2-3-8-6(7)4-5/h5H,2-4H2,1H3,(H2,7,8)
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PubMed
n/an/a 100n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062132
PNG
(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Show SMILES CCCC1CCCC(N)=N1 |c:8|
Show InChI InChI=1S/C8H16N2/c1-2-4-7-5-3-6-8(9)10-7/h7H,2-6H2,1H3,(H2,9,10)
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n/an/a 200n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062133
PNG
(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Show SMILES CC1CCN=C(N)C1 |t:4|
Show InChI InChI=1S/C6H12N2/c1-5-2-3-8-6(7)4-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 200n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062142
PNG
(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Show SMILES CC1CC(C)N=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-5-3-6(2)9-7(8)4-5/h5-6H,3-4H2,1-2H3,(H2,8,9)
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n/an/a 300n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062137
PNG
(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Show SMILES CC1CCCC(N)=N1 |c:6|
Show InChI InChI=1S/C6H12N2/c1-5-3-2-4-6(7)8-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 400n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062131
PNG
(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Show SMILES NC1=NC(CCC1)C(F)(F)F |t:1|
Show InChI InChI=1S/C6H9F3N2/c7-6(8,9)4-2-1-3-5(10)11-4/h4H,1-3H2,(H2,10,11)
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n/an/a 500n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062137
PNG
(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Show SMILES CC1CCCC(N)=N1 |c:6|
Show InChI InChI=1S/C6H12N2/c1-5-3-2-4-6(7)8-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 500n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062131
PNG
(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Show SMILES NC1=NC(CCC1)C(F)(F)F |t:1|
Show InChI InChI=1S/C6H9F3N2/c7-6(8,9)4-2-1-3-5(10)11-4/h4H,1-3H2,(H2,10,11)
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n/an/a 500n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062132
PNG
(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Show SMILES CCCC1CCCC(N)=N1 |c:8|
Show InChI InChI=1S/C8H16N2/c1-2-4-7-5-3-6-8(9)10-7/h7H,2-6H2,1H3,(H2,9,10)
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n/an/a 500n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062137
PNG
(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Show SMILES CC1CCCC(N)=N1 |c:6|
Show InChI InChI=1S/C6H12N2/c1-5-3-2-4-6(7)8-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 600n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062145
PNG
(3-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26716...)
Show SMILES CC1CCCN=C1N |c:5|
Show InChI InChI=1S/C6H12N2/c1-5-3-2-4-8-6(5)7/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 700n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062136
PNG
(6-Benzyl-piperidin-(2Z)-ylideneamine | CHEMBL6875)
Show SMILES NC1=NC(Cc2ccccc2)CCC1 |t:1|
Show InChI InChI=1S/C12H16N2/c13-12-8-4-7-11(14-12)9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,13,14)
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n/an/a 900n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50049255
PNG
(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Show SMILES NC1=NCCCC1 |t:1|
Show InChI InChI=1S/C5H10N2/c6-5-3-1-2-4-7-5/h1-4H2,(H2,6,7)
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n/an/a 1.10E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50049255
PNG
(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Show SMILES NC1=NCCCC1 |t:1|
Show InChI InChI=1S/C5H10N2/c6-5-3-1-2-4-7-5/h1-4H2,(H2,6,7)
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n/an/a 1.10E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062133
PNG
(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Show SMILES CC1CCN=C(N)C1 |t:4|
Show InChI InChI=1S/C6H12N2/c1-5-2-3-8-6(7)4-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 1.10E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062135
PNG
(4-Ethyl-piperidin-(2Z)-ylideneamine | CHEMBL6813)
Show SMILES CCC1CCN=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-2-6-3-4-9-7(8)5-6/h6H,2-5H2,1H3,(H2,8,9)
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n/an/a 1.60E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062131
PNG
(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Show SMILES NC1=NC(CCC1)C(F)(F)F |t:1|
Show InChI InChI=1S/C6H9F3N2/c7-6(8,9)4-2-1-3-5(10)11-4/h4H,1-3H2,(H2,10,11)
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n/an/a 2.00E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062132
PNG
(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Show SMILES CCCC1CCCC(N)=N1 |c:8|
Show InChI InChI=1S/C8H16N2/c1-2-4-7-5-3-6-8(9)10-7/h7H,2-6H2,1H3,(H2,9,10)
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n/an/a 2.20E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062135
PNG
(4-Ethyl-piperidin-(2Z)-ylideneamine | CHEMBL6813)
Show SMILES CCC1CCN=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-2-6-3-4-9-7(8)5-6/h6H,2-5H2,1H3,(H2,8,9)
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n/an/a 2.60E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062145
PNG
(3-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26716...)
Show SMILES CC1CCCN=C1N |c:5|
Show InChI InChI=1S/C6H12N2/c1-5-3-2-4-8-6(5)7/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 3.00E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062138
PNG
(4-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Show SMILES NC1=NCCC(C1)C(F)(F)F |t:1|
Show InChI InChI=1S/C6H9F3N2/c7-6(8,9)4-1-2-11-5(10)3-4/h4H,1-3H2,(H2,10,11)
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n/an/a 3.20E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062138
PNG
(4-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Show SMILES NC1=NCCC(C1)C(F)(F)F |t:1|
Show InChI InChI=1S/C6H9F3N2/c7-6(8,9)4-1-2-11-5(10)3-4/h4H,1-3H2,(H2,10,11)
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n/an/a 3.30E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062140
PNG
(4,4-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL6...)
Show SMILES CC1(C)CCN=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-7(2)3-4-9-6(8)5-7/h3-5H2,1-2H3,(H2,8,9)
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n/an/a 3.40E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062139
PNG
(5-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26933...)
Show SMILES CC1CCC(N)=NC1 |c:5|
Show InChI InChI=1S/C6H12N2/c1-5-2-3-6(7)8-4-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 4.50E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50049255
PNG
(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Show SMILES NC1=NCCCC1 |t:1|
Show InChI InChI=1S/C5H10N2/c6-5-3-1-2-4-7-5/h1-4H2,(H2,6,7)
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n/an/a 4.70E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062139
PNG
(5-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26933...)
Show SMILES CC1CCC(N)=NC1 |c:5|
Show InChI InChI=1S/C6H12N2/c1-5-2-3-6(7)8-4-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 5.10E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062143
PNG
(6-Cyclohexyl-piperidin-(2Z)-ylideneamine | CHEMBL7...)
Show SMILES NC1=NC(CCC1)C1CCCCC1 |t:1|
Show InChI InChI=1S/C11H20N2/c12-11-8-4-7-10(13-11)9-5-2-1-3-6-9/h9-10H,1-8H2,(H2,12,13)
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n/an/a 5.30E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062140
PNG
(4,4-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL6...)
Show SMILES CC1(C)CCN=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-7(2)3-4-9-6(8)5-7/h3-5H2,1-2H3,(H2,8,9)
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n/an/a 5.30E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062134
PNG
(6-Cyclohexylmethyl-piperidin-(2Z)-ylideneamine | C...)
Show SMILES NC1=NC(CC2CCCCC2)CCC1 |t:1|
Show InChI InChI=1S/C12H22N2/c13-12-8-4-7-11(14-12)9-10-5-2-1-3-6-10/h10-11H,1-9H2,(H2,13,14)
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n/an/a 5.90E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062140
PNG
(4,4-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL6...)
Show SMILES CC1(C)CCN=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-7(2)3-4-9-6(8)5-7/h3-5H2,1-2H3,(H2,8,9)
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n/an/a 5.90E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062145
PNG
(3-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26716...)
Show SMILES CC1CCCN=C1N |c:5|
Show InChI InChI=1S/C6H12N2/c1-5-3-2-4-8-6(5)7/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 6.00E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062143
PNG
(6-Cyclohexyl-piperidin-(2Z)-ylideneamine | CHEMBL7...)
Show SMILES NC1=NC(CCC1)C1CCCCC1 |t:1|
Show InChI InChI=1S/C11H20N2/c12-11-8-4-7-10(13-11)9-5-2-1-3-6-9/h9-10H,1-8H2,(H2,12,13)
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n/an/a 8.70E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062136
PNG
(6-Benzyl-piperidin-(2Z)-ylideneamine | CHEMBL6875)
Show SMILES NC1=NC(Cc2ccccc2)CCC1 |t:1|
Show InChI InChI=1S/C12H16N2/c13-12-8-4-7-11(14-12)9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,13,14)
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n/an/a 9.20E+3n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062135
PNG
(4-Ethyl-piperidin-(2Z)-ylideneamine | CHEMBL6813)
Show SMILES CCC1CCN=C(N)C1 |t:5|
Show InChI InChI=1S/C7H14N2/c1-2-6-3-4-9-7(8)5-6/h6H,2-5H2,1H3,(H2,8,9)
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n/an/a 1.30E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062129
PNG
(3,4-Dihydro-1H-quinolin-(2E)-ylideneamine | 3,4-Di...)
Show SMILES NC1=Nc2ccccc2CC1 |t:1|
Show InChI InChI=1S/C9H10N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2,(H2,10,11)
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n/an/a 2.80E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062134
PNG
(6-Cyclohexylmethyl-piperidin-(2Z)-ylideneamine | C...)
Show SMILES NC1=NC(CC2CCCCC2)CCC1 |t:1|
Show InChI InChI=1S/C12H22N2/c13-12-8-4-7-11(14-12)9-10-5-2-1-3-6-10/h10-11H,1-9H2,(H2,13,14)
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n/an/a 2.80E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062136
PNG
(6-Benzyl-piperidin-(2Z)-ylideneamine | CHEMBL6875)
Show SMILES NC1=NC(Cc2ccccc2)CCC1 |t:1|
Show InChI InChI=1S/C12H16N2/c13-12-8-4-7-11(14-12)9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,13,14)
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n/an/a 4.40E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062138
PNG
(4-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Show SMILES NC1=NCCC(C1)C(F)(F)F |t:1|
Show InChI InChI=1S/C6H9F3N2/c7-6(8,9)4-1-2-11-5(10)3-4/h4H,1-3H2,(H2,10,11)
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n/an/a 4.70E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062139
PNG
(5-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26933...)
Show SMILES CC1CCC(N)=NC1 |c:5|
Show InChI InChI=1S/C6H12N2/c1-5-2-3-6(7)8-4-5/h5H,2-4H2,1H3,(H2,7,8)
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n/an/a 5.80E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062129
PNG
(3,4-Dihydro-1H-quinolin-(2E)-ylideneamine | 3,4-Di...)
Show SMILES NC1=Nc2ccccc2CC1 |t:1|
Show InChI InChI=1S/C9H10N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2,(H2,10,11)
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n/an/a 9.90E+4n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062130
PNG
(4-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6657)
Show SMILES CCCC1CCN=C(N)C1 |t:6|
Show InChI InChI=1S/C8H16N2/c1-2-3-7-4-5-10-8(9)6-7/h7H,2-6H2,1H3,(H2,9,10)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062144
PNG
(CHEMBL268294 | Methyl-piperidin-(2Z)-ylidene-amine)
Show SMILES CNC1=NCCCC1 |t:2|
Show InChI InChI=1S/C6H12N2/c1-7-6-4-2-3-5-8-6/h2-5H2,1H3,(H,7,8)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062141
PNG
(1-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26698...)
Show SMILES CN1CCCCC1=N
Show InChI InChI=1S/C6H12N2/c1-8-5-3-2-4-6(8)7/h7H,2-5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062130
PNG
(4-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6657)
Show SMILES CCCC1CCN=C(N)C1 |t:6|
Show InChI InChI=1S/C8H16N2/c1-2-3-7-4-5-10-8(9)6-7/h7H,2-6H2,1H3,(H2,9,10)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062144
PNG
(CHEMBL268294 | Methyl-piperidin-(2Z)-ylidene-amine)
Show SMILES CNC1=NCCCC1 |t:2|
Show InChI InChI=1S/C6H12N2/c1-7-6-4-2-3-5-8-6/h2-5H2,1H3,(H,7,8)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062130
PNG
(4-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6657)
Show SMILES CCCC1CCN=C(N)C1 |t:6|
Show InChI InChI=1S/C8H16N2/c1-2-3-7-4-5-10-8(9)6-7/h7H,2-6H2,1H3,(H2,9,10)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, inducible


(Homo sapiens (Human))
BDBM50062141
PNG
(1-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26698...)
Show SMILES CN1CCCCC1=N
Show InChI InChI=1S/C6H12N2/c1-8-5-3-2-4-6(8)7/h7H,2-5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Inducible nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062144
PNG
(CHEMBL268294 | Methyl-piperidin-(2Z)-ylidene-amine)
Show SMILES CNC1=NCCCC1 |t:2|
Show InChI InChI=1S/C6H12N2/c1-7-6-4-2-3-5-8-6/h2-5H2,1H3,(H,7,8)
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50062141
PNG
(1-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26698...)
Show SMILES CN1CCCCC1=N
Show InChI InChI=1S/C6H12N2/c1-8-5-3-2-4-6(8)7/h7H,2-5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Neuronal nitric oxide synthase


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062143
PNG
(6-Cyclohexyl-piperidin-(2Z)-ylideneamine | CHEMBL7...)
Show SMILES NC1=NC(CCC1)C1CCCCC1 |t:1|
Show InChI InChI=1S/C11H20N2/c12-11-8-4-7-10(13-11)9-5-2-1-3-6-9/h9-10H,1-8H2,(H2,12,13)
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n/an/a 1.42E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062129
PNG
(3,4-Dihydro-1H-quinolin-(2E)-ylideneamine | 3,4-Di...)
Show SMILES NC1=Nc2ccccc2CC1 |t:1|
Show InChI InChI=1S/C9H10N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2,(H2,10,11)
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n/an/a 2.18E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
Nitric oxide synthase, endothelial


(Homo sapiens (Human))
BDBM50062134
PNG
(6-Cyclohexylmethyl-piperidin-(2Z)-ylideneamine | C...)
Show SMILES NC1=NC(CC2CCCCC2)CCC1 |t:1|
Show InChI InChI=1S/C12H22N2/c13-12-8-4-7-11(14-12)9-10-5-2-1-3-6-10/h10-11H,1-9H2,(H2,13,14)
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n/an/a 3.75E+5n/an/an/an/an/an/a



G. D. Searle Research and Development

Curated by ChEMBL


Assay Description
inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)


J Med Chem 41: 96-101 (1998)


Article DOI: 10.1021/jm9705059
BindingDB Entry DOI: 10.7270/Q2GM86D2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%