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PubMed code 9871564

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069258
PNG
(3-Benzhydrylidene-1-{4-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H32FN3O2/c32-26-13-15-27(16-14-26)34-21-19-33(20-22-34)17-7-8-18-35-29(36)23-28(31(35)37)30(24-9-3-1-4-10-24)25-11-5-2-6-12-25/h1-6,9-16H,7-8,17-23H2
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 3.30n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069265
PNG
(3-Benzhydrylidene-1-[3-(4-phenyl-piperazin-1-yl)-p...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O2/c34-28-23-27(29(24-11-4-1-5-12-24)25-13-6-2-7-14-25)30(35)33(28)18-10-17-31-19-21-32(22-20-31)26-15-8-3-9-16-26/h1-9,11-16H,10,17-23H2
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 5.70n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069261
PNG
(3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2
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 6.40n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069254
PNG
(3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H33N3O3/c1-37-28-16-9-8-15-27(28)33-21-19-32(20-22-33)17-10-18-34-29(35)23-26(31(34)36)30(24-11-4-2-5-12-24)25-13-6-3-7-14-25/h2-9,11-16H,10,17-23H2,1H3
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 8.10n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069268
PNG
(3-Benzhydrylidene-1-{3-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H30FN3O2/c31-25-12-14-26(15-13-25)33-20-18-32(19-21-33)16-7-17-34-28(35)22-27(30(34)36)29(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15H,7,16-22H2
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 8.30n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069249
PNG
(3-Benzhydrylidene-1-{4-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C32H35N3O3/c1-38-29-17-9-8-16-28(29)34-22-20-33(21-23-34)18-10-11-19-35-30(36)24-27(32(35)37)31(25-12-4-2-5-13-25)26-14-6-3-7-15-26/h2-9,12-17H,10-11,18-24H2,1H3
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 13n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069249
PNG
(3-Benzhydrylidene-1-{4-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C32H35N3O3/c1-38-29-17-9-8-16-28(29)34-22-20-33(21-23-34)18-10-11-19-35-30(36)24-27(32(35)37)31(25-12-4-2-5-13-25)26-14-6-3-7-15-26/h2-9,12-17H,10-11,18-24H2,1H3
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 14n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM59418
PNG
(1-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-3-(d...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H32ClN3O2/c32-26-14-9-15-27(22-26)34-20-18-33(19-21-34)16-7-8-17-35-29(36)23-28(31(35)37)30(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-6,9-15,22H,7-8,16-21,23H2
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 16n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069260
PNG
(3-Benzhydrylidene-1-{4-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C32H32F3N3O2/c33-32(34,35)26-14-9-15-27(22-26)37-20-18-36(19-21-37)16-7-8-17-38-29(39)23-28(31(38)40)30(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-6,9-15,22H,7-8,16-21,23H2
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 16n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM59418
PNG
(1-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-3-(d...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H32ClN3O2/c32-26-14-9-15-27(22-26)34-20-18-33(19-21-34)16-7-8-17-35-29(36)23-28(31(35)37)30(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-6,9-15,22H,7-8,16-21,23H2
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 39n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069264
PNG
(3-Benzhydrylidene-1-{3-[4-(3-chloro-phenyl)-pipera...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H30ClN3O2/c31-25-13-7-14-26(21-25)33-19-17-32(18-20-33)15-8-16-34-28(35)22-27(30(34)36)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-7,9-14,21H,8,15-20,22H2
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 39n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069250
PNG
(3-Benzhydrylidene-1-[4-(3-chloro-phenyl)-piperazin...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C28H26ClN3O2/c29-23-12-7-13-24(18-23)31-16-14-30(15-17-31)20-32-26(33)19-25(28(32)34)27(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18H,14-17,19-20H2
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 49n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069258
PNG
(3-Benzhydrylidene-1-{4-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H32FN3O2/c32-26-13-15-27(16-14-26)34-21-19-33(20-22-34)17-7-8-18-35-29(36)23-28(31(35)37)30(24-9-3-1-4-10-24)25-11-5-2-6-12-25/h1-6,9-16H,7-8,17-23H2
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 52n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069257
PNG
(3-Benzhydrylidene-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H26F3N3O2/c30-29(31,32)23-12-7-13-24(18-23)34-16-14-33(15-17-34)20-35-26(36)19-25(28(35)37)27(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18H,14-17,19-20H2
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 60n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069260
PNG
(3-Benzhydrylidene-1-{4-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C32H32F3N3O2/c33-32(34,35)26-14-9-15-27(22-26)37-20-18-36(19-21-37)16-7-8-17-38-29(39)23-28(31(38)40)30(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-6,9-15,22H,7-8,16-21,23H2
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 61n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069259
PNG
(3-Benzhydrylidene-1-{3-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H30F3N3O2/c32-31(33,34)25-13-7-14-26(21-25)36-19-17-35(18-20-36)15-8-16-37-28(38)22-27(30(37)39)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-7,9-14,21H,8,15-20,22H2
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 63n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069256
PNG
(3-Benzhydrylidene-1-{2-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H31N3O3/c1-36-27-15-9-8-14-26(27)32-19-16-31(17-20-32)18-21-33-28(34)22-25(30(33)35)29(23-10-4-2-5-11-23)24-12-6-3-7-13-24/h2-15H,16-22H2,1H3
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 72n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069262
PNG
(3-Benzhydrylidene-1-[4-(2-methoxy-phenyl)-piperazi...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H29N3O3/c1-35-26-15-9-8-14-25(26)31-18-16-30(17-19-31)21-32-27(33)20-24(29(32)34)28(22-10-4-2-5-11-22)23-12-6-3-7-13-23/h2-15H,16-21H2,1H3
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 94n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069266
PNG
(3-Benzhydrylidene-1-(4-phenyl-piperazin-1-ylmethyl...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](\c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C28H27N3O2/c32-26-20-25(27(22-10-4-1-5-11-22)23-12-6-2-7-13-23)28(33)31(26)21-29-16-18-30(19-17-29)24-14-8-3-9-15-24/h1-15H,16-21H2
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 98n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069261
PNG
(3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2
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 125n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069264
PNG
(3-Benzhydrylidene-1-{3-[4-(3-chloro-phenyl)-pipera...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H30ClN3O2/c31-25-13-7-14-26(21-25)33-19-17-32(18-20-33)15-8-16-34-28(35)22-27(30(34)36)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-7,9-14,21H,8,15-20,22H2
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 127n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069254
PNG
(3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H33N3O3/c1-37-28-16-9-8-15-27(28)33-21-19-32(20-22-33)17-10-18-34-29(35)23-26(31(34)36)30(24-11-4-2-5-12-24)25-13-6-3-7-14-25/h2-9,11-16H,10,17-23H2,1H3
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 156n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069256
PNG
(3-Benzhydrylidene-1-{2-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H31N3O3/c1-36-27-15-9-8-14-26(27)32-19-16-31(17-20-32)18-21-33-28(34)22-25(30(33)35)29(23-10-4-2-5-11-23)24-12-6-3-7-13-24/h2-15H,16-22H2,1H3
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 167n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069263
PNG
(3-Benzhydrylidene-1-[2-(4-phenyl-piperazin-1-yl)-e...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](\c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O2/c33-27-22-26(28(23-10-4-1-5-11-23)24-12-6-2-7-13-24)29(34)32(27)21-18-30-16-19-31(20-17-30)25-14-8-3-9-15-25/h1-15H,16-22H2
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 214n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069256
PNG
(3-Benzhydrylidene-1-{2-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H31N3O3/c1-36-27-15-9-8-14-26(27)32-19-16-31(17-20-32)18-21-33-28(34)22-25(30(33)35)29(23-10-4-2-5-11-23)24-12-6-3-7-13-24/h2-15H,16-22H2,1H3
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 286n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069258
PNG
(3-Benzhydrylidene-1-{4-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H32FN3O2/c32-26-13-15-27(16-14-26)34-21-19-33(20-22-34)17-7-8-18-35-29(36)23-28(31(35)37)30(24-9-3-1-4-10-24)25-11-5-2-6-12-25/h1-6,9-16H,7-8,17-23H2
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 351n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM59418
PNG
(1-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-3-(d...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H32ClN3O2/c32-26-14-9-15-27(22-26)34-20-18-33(19-21-34)16-7-8-17-35-29(36)23-28(31(35)37)30(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-6,9-15,22H,7-8,16-21,23H2
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 367n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069250
PNG
(3-Benzhydrylidene-1-[4-(3-chloro-phenyl)-piperazin...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C28H26ClN3O2/c29-23-12-7-13-24(18-23)31-16-14-30(15-17-31)20-32-26(33)19-25(28(32)34)27(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18H,14-17,19-20H2
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 392n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069252
PNG
(3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H28FN3O2/c30-24-11-13-25(14-12-24)32-18-15-31(16-19-32)17-20-33-27(34)21-26(29(33)35)28(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14H,15-21H2
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 529n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069254
PNG
(3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H33N3O3/c1-37-28-16-9-8-15-27(28)33-21-19-32(20-22-33)17-10-18-34-29(35)23-26(31(34)36)30(24-11-4-2-5-12-24)25-13-6-3-7-14-25/h2-9,11-16H,10,17-23H2,1H3
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 665n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069260
PNG
(3-Benzhydrylidene-1-{4-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C32H32F3N3O2/c33-32(34,35)26-14-9-15-27(22-26)37-20-18-36(19-21-37)16-7-8-17-38-29(39)23-28(31(38)40)30(24-10-3-1-4-11-24)25-12-5-2-6-13-25/h1-6,9-15,22H,7-8,16-21,23H2
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 689n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069267
PNG
(3-Benzhydrylidene-1-[4-(4-fluoro-phenyl)-piperazin...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C28H26FN3O2/c29-23-11-13-24(14-12-23)31-17-15-30(16-18-31)20-32-26(33)19-25(28(32)34)27(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14H,15-20H2
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 746n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069264
PNG
(3-Benzhydrylidene-1-{3-[4-(3-chloro-phenyl)-pipera...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H30ClN3O2/c31-25-13-7-14-26(21-25)33-19-17-32(18-20-33)15-8-16-34-28(35)22-27(30(34)36)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-7,9-14,21H,8,15-20,22H2
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 801n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069257
PNG
(3-Benzhydrylidene-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H26F3N3O2/c30-29(31,32)23-12-7-13-24(18-23)34-16-14-33(15-17-34)20-35-26(36)19-25(28(35)37)27(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18H,14-17,19-20H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069268
PNG
(3-Benzhydrylidene-1-{3-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H30FN3O2/c31-25-12-14-26(15-13-25)33-20-18-32(19-21-33)16-7-17-34-28(35)22-27(30(34)36)29(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15H,7,16-22H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069251
PNG
(3-Benzhydrylidene-1-{2-[4-(3-chloro-phenyl)-pipera...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H28ClN3O2/c30-24-12-7-13-25(20-24)32-17-14-31(15-18-32)16-19-33-27(34)21-26(29(33)35)28(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,20H,14-19,21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069266
PNG
(3-Benzhydrylidene-1-(4-phenyl-piperazin-1-ylmethyl...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](\c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C28H27N3O2/c32-26-20-25(27(22-10-4-1-5-11-22)23-12-6-2-7-13-23)28(33)31(26)21-29-16-18-30(19-17-29)24-14-8-3-9-15-24/h1-15H,16-21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069265
PNG
(3-Benzhydrylidene-1-[3-(4-phenyl-piperazin-1-yl)-p...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O2/c34-28-23-27(29(24-11-4-1-5-12-24)25-13-6-2-7-14-25)30(35)33(28)18-10-17-31-19-21-32(22-20-31)26-15-8-3-9-16-26/h1-9,11-16H,10,17-23H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069262
PNG
(3-Benzhydrylidene-1-[4-(2-methoxy-phenyl)-piperazi...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H29N3O3/c1-35-26-15-9-8-14-25(26)31-18-16-30(17-19-31)21-32-27(33)20-24(29(32)34)28(22-10-4-2-5-11-22)23-12-6-3-7-13-23/h2-15H,16-21H2,1H3
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069268
PNG
(3-Benzhydrylidene-1-{3-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H30FN3O2/c31-25-12-14-26(15-13-25)33-20-18-32(19-21-33)16-7-17-34-28(35)22-27(30(34)36)29(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-6,8-15H,7,16-22H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069263
PNG
(3-Benzhydrylidene-1-[2-(4-phenyl-piperazin-1-yl)-e...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](\c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O2/c33-27-22-26(28(23-10-4-1-5-11-23)24-12-6-2-7-13-24)29(34)32(27)21-18-30-16-19-31(20-17-30)25-14-8-3-9-15-25/h1-15H,16-22H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069263
PNG
(3-Benzhydrylidene-1-[2-(4-phenyl-piperazin-1-yl)-e...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](\c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O2/c33-27-22-26(28(23-10-4-1-5-11-23)24-12-6-2-7-13-24)29(34)32(27)21-18-30-16-19-31(20-17-30)25-14-8-3-9-15-25/h1-15H,16-22H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069265
PNG
(3-Benzhydrylidene-1-[3-(4-phenyl-piperazin-1-yl)-p...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O2/c34-28-23-27(29(24-11-4-1-5-12-24)25-13-6-2-7-14-25)30(35)33(28)18-10-17-31-19-21-32(22-20-31)26-15-8-3-9-16-26/h1-9,11-16H,10,17-23H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069249
PNG
(3-Benzhydrylidene-1-{4-[4-(2-methoxy-phenyl)-piper...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C32H35N3O3/c1-38-29-17-9-8-16-28(29)34-22-20-33(21-23-34)18-10-11-19-35-30(36)24-27(32(35)37)31(25-12-4-2-5-13-25)26-14-6-3-7-15-26/h2-9,12-17H,10-11,18-24H2,1H3
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069267
PNG
(3-Benzhydrylidene-1-[4-(4-fluoro-phenyl)-piperazin...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C28H26FN3O2/c29-23-11-13-24(14-12-23)31-17-15-30(16-18-31)20-32-26(33)19-25(28(32)34)27(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14H,15-20H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069251
PNG
(3-Benzhydrylidene-1-{2-[4-(3-chloro-phenyl)-pipera...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H28ClN3O2/c30-24-12-7-13-25(20-24)32-17-14-31(15-18-32)16-19-33-27(34)21-26(29(33)35)28(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,20H,14-19,21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069252
PNG
(3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H28FN3O2/c30-24-11-13-25(14-12-24)32-18-15-31(16-19-32)17-20-33-27(34)21-26(29(33)35)28(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14H,15-21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069259
PNG
(3-Benzhydrylidene-1-{3-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H30F3N3O2/c32-31(33,34)25-13-7-14-26(21-25)36-19-17-35(18-20-36)15-8-16-37-28(38)22-27(30(37)39)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-7,9-14,21H,8,15-20,22H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069250
PNG
(3-Benzhydrylidene-1-[4-(3-chloro-phenyl)-piperazin...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C28H26ClN3O2/c29-23-12-7-13-24(18-23)31-16-14-30(15-17-31)20-32-26(33)19-25(28(32)34)27(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18H,14-17,19-20H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069266
PNG
(3-Benzhydrylidene-1-(4-phenyl-piperazin-1-ylmethyl...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](\c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C28H27N3O2/c32-26-20-25(27(22-10-4-1-5-11-22)23-12-6-2-7-13-23)28(33)31(26)21-29-16-18-30(19-17-29)24-14-8-3-9-15-24/h1-15H,16-21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069267
PNG
(3-Benzhydrylidene-1-[4-(4-fluoro-phenyl)-piperazin...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C28H26FN3O2/c29-23-11-13-24(14-12-23)31-17-15-30(16-18-31)20-32-26(33)19-25(28(32)34)27(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14H,15-20H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069257
PNG
(3-Benzhydrylidene-1-[4-(3-trifluoromethyl-phenyl)-...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H26F3N3O2/c30-29(31,32)23-12-7-13-24(18-23)34-16-14-33(15-17-34)20-35-26(36)19-25(28(35)37)27(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18H,14-17,19-20H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069261
PNG
(3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...)
Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1
Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069253
PNG
(3-Benzhydrylidene-1-{2-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H28F3N3O2/c31-30(32,33)24-12-7-13-25(20-24)35-17-14-34(15-18-35)16-19-36-27(37)21-26(29(36)38)28(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,20H,14-19,21H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069251
PNG
(3-Benzhydrylidene-1-{2-[4-(3-chloro-phenyl)-pipera...)
Show SMILES Clc1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H28ClN3O2/c30-24-12-7-13-25(20-24)32-17-14-31(15-18-32)16-19-33-27(34)21-26(29(33)35)28(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,20H,14-19,21H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069253
PNG
(3-Benzhydrylidene-1-{2-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H28F3N3O2/c31-30(32,33)24-12-7-13-25(20-24)35-17-14-34(15-18-35)16-19-36-27(37)21-26(29(36)38)28(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,20H,14-19,21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069262
PNG
(3-Benzhydrylidene-1-[4-(2-methoxy-phenyl)-piperazi...)
Show SMILES [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H29N3O3/c1-35-26-15-9-8-14-25(26)31-18-16-30(17-19-31)21-32-27(33)20-24(29(32)34)28(22-10-4-2-5-11-22)23-12-6-3-7-13-23/h2-15H,16-21H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50069252
PNG
(3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...)
Show SMILES Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C29H28FN3O2/c30-24-11-13-25(14-12-24)32-18-15-31(16-19-32)17-20-33-27(34)21-26(29(33)35)28(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14H,15-21H2
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Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50069253
PNG
(3-Benzhydrylidene-1-{2-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](\c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C30H28F3N3O2/c31-30(32,33)24-12-7-13-25(20-24)35-17-14-34(15-18-35)16-19-36-27(37)21-26(29(36)38)28(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,20H,14-19,21H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069259
PNG
(3-Benzhydrylidene-1-{3-[4-(3-trifluoromethyl-pheny...)
Show SMILES FC(F)(F)c1cccc(c1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
Show InChI InChI=1S/C31H30F3N3O2/c32-31(33,34)25-13-7-14-26(21-25)36-19-17-35(18-20-36)15-8-16-37-28(38)22-27(30(37)39)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-7,9-14,21H,8,15-20,22H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand

Bioorg Med Chem Lett 8: 581-6 (1999)


BindingDB Entry DOI: 10.7270/Q2N878XB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%