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USPatent US10183940

Compile data set for download or QSAR
Found 124 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
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 21.7n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322587
PNG
(US10183940, Example 39)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-14-7-5-9-16(22)17(14)26(3)25-19)24-20(27)15-8-4-6-13-12-23-10-11-28-18(13)15/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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 29.1n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322565
PNG
(US10183940, Example 18)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-21(2,19-15-8-4-5-10-17(15)25(3)24-19)23-20(26)16-9-6-7-14-13-22-11-12-27-18(14)16/h4-10,22H,11-13H2,1-3H3,(H,23,26)
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 39.5n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322595
PNG
(US10183940, Example 47)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(14)13-23-20(25)21(2,3)24-19(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
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 53.2n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322573
PNG
(US10183940, Example 26)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-16-8-4-5-9-17(16)20(26-25-14)22(2,3)24-21(27)18-10-6-7-15-13-23-11-12-28-19(15)18/h4-10,23H,11-13H2,1-3H3,(H,24,27)
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 65n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322553
PNG
(US10183940, Example 6)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccnc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-11-24-19-9-4-3-7-16(18)19)25-21(26)17-8-5-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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 104n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322590
PNG
(US10183940, Example 42)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-15-17(13)26(4)25-19(15)21(2,3)24-20(27)16-12-23-11-14-10-22-8-9-28-18(14)16/h5-7,11-12,22H,8-10H2,1-4H3,(H,24,27)
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 532n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322567
PNG
(US10183940, Example 20)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-13-6-4-5-7-16(13)25(3)24-18)23-19(26)14-8-9-22-15-12-21-10-11-27-17(14)15/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 574n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322566
PNG
(US10183940, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-15(14)25(3)24-18)23-19(26)16-17-13(8-9-22-16)12-21-10-11-27-17/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 613n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322565
PNG
(US10183940, Example 18)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-21(2,19-15-8-4-5-10-17(15)25(3)24-19)23-20(26)16-9-6-7-14-13-22-11-12-27-18(14)16/h4-10,22H,11-13H2,1-3H3,(H,23,26)
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 7.82E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322567
PNG
(US10183940, Example 20)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-13-6-4-5-7-16(13)25(3)24-18)23-19(26)14-8-9-22-15-12-21-10-11-27-17(14)15/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 8.62E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322566
PNG
(US10183940, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-15(14)25(3)24-18)23-19(26)16-17-13(8-9-22-16)12-21-10-11-27-17/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322590
PNG
(US10183940, Example 42)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-15-17(13)26(4)25-19(15)21(2,3)24-20(27)16-12-23-11-14-10-22-8-9-28-18(14)16/h5-7,11-12,22H,8-10H2,1-4H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322573
PNG
(US10183940, Example 26)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-16-8-4-5-9-17(16)20(26-25-14)22(2,3)24-21(27)18-10-6-7-15-13-23-11-12-28-19(15)18/h4-10,23H,11-13H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322565
PNG
(US10183940, Example 18)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-21(2,19-15-8-4-5-10-17(15)25(3)24-19)23-20(26)16-9-6-7-14-13-22-11-12-27-18(14)16/h4-10,22H,11-13H2,1-3H3,(H,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322587
PNG
(US10183940, Example 39)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-14-7-5-9-16(22)17(14)26(3)25-19)24-20(27)15-8-4-6-13-12-23-10-11-28-18(13)15/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322553
PNG
(US10183940, Example 6)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccnc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-11-24-19-9-4-3-7-16(18)19)25-21(26)17-8-5-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))		BDBM322595
PNG
(US10183940, Example 47)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(14)13-23-20(25)21(2,3)24-19(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322553
PNG
(US10183940, Example 6)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccnc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-11-24-19-9-4-3-7-16(18)19)25-21(26)17-8-5-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322587
PNG
(US10183940, Example 39)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-14-7-5-9-16(22)17(14)26(3)25-19)24-20(27)15-8-4-6-13-12-23-10-11-28-18(13)15/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322595
PNG
(US10183940, Example 47)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(14)13-23-20(25)21(2,3)24-19(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
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 9.01E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
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 9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322566
PNG
(US10183940, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-15(14)25(3)24-18)23-19(26)16-17-13(8-9-22-16)12-21-10-11-27-17/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322590
PNG
(US10183940, Example 42)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-15-17(13)26(4)25-19(15)21(2,3)24-20(27)16-12-23-11-14-10-22-8-9-28-18(14)16/h5-7,11-12,22H,8-10H2,1-4H3,(H,24,27)
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 9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322573
PNG
(US10183940, Example 26)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-16-8-4-5-9-17(16)20(26-25-14)22(2,3)24-21(27)18-10-6-7-15-13-23-11-12-28-19(15)18/h4-10,23H,11-13H2,1-3H3,(H,24,27)
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 9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))		BDBM322567
PNG
(US10183940, Example 20)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-13-6-4-5-7-16(13)25(3)24-18)23-19(26)14-8-9-22-15-12-21-10-11-27-17(14)15/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322573
PNG
(US10183940, Example 26)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-16-8-4-5-9-17(16)20(26-25-14)22(2,3)24-21(27)18-10-6-7-15-13-23-11-12-28-19(15)18/h4-10,23H,11-13H2,1-3H3,(H,24,27)
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 9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322566
PNG
(US10183940, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-15(14)25(3)24-18)23-19(26)16-17-13(8-9-22-16)12-21-10-11-27-17/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
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 9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322590
PNG
(US10183940, Example 42)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-15-17(13)26(4)25-19(15)21(2,3)24-20(27)16-12-23-11-14-10-22-8-9-28-18(14)16/h5-7,11-12,22H,8-10H2,1-4H3,(H,24,27)
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 9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322567
PNG
(US10183940, Example 20)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-13-6-4-5-7-16(13)25(3)24-18)23-19(26)14-8-9-22-15-12-21-10-11-27-17(14)15/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322565
PNG
(US10183940, Example 18)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-21(2,19-15-8-4-5-10-17(15)25(3)24-19)23-20(26)16-9-6-7-14-13-22-11-12-27-18(14)16/h4-10,22H,11-13H2,1-3H3,(H,23,26)
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 9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322595
PNG
(US10183940, Example 47)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(14)13-23-20(25)21(2,3)24-19(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
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 9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322553
PNG
(US10183940, Example 6)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccnc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-11-24-19-9-4-3-7-16(18)19)25-21(26)17-8-5-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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 9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))		BDBM322587
PNG
(US10183940, Example 39)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-14-7-5-9-16(22)17(14)26(3)25-19)24-20(27)15-8-4-6-13-12-23-10-11-28-18(13)15/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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 9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322590
PNG
(US10183940, Example 42)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-15-17(13)26(4)25-19(15)21(2,3)24-20(27)16-12-23-11-14-10-22-8-9-28-18(14)16/h5-7,11-12,22H,8-10H2,1-4H3,(H,24,27)
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 9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322566
PNG
(US10183940, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-15(14)25(3)24-18)23-19(26)16-17-13(8-9-22-16)12-21-10-11-27-17/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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 9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322573
PNG
(US10183940, Example 26)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-16-8-4-5-9-17(16)20(26-25-14)22(2,3)24-21(27)18-10-6-7-15-13-23-11-12-28-19(15)18/h4-10,23H,11-13H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322567
PNG
(US10183940, Example 20)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-13-6-4-5-7-16(13)25(3)24-18)23-19(26)14-8-9-22-15-12-21-10-11-27-17(14)15/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322587
PNG
(US10183940, Example 39)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-14-7-5-9-16(22)17(14)26(3)25-19)24-20(27)15-8-4-6-13-12-23-10-11-28-18(13)15/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322595
PNG
(US10183940, Example 47)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(14)13-23-20(25)21(2,3)24-19(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322565
PNG
(US10183940, Example 18)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-21(2,19-15-8-4-5-10-17(15)25(3)24-19)23-20(26)16-9-6-7-14-13-22-11-12-27-18(14)16/h4-10,22H,11-13H2,1-3H3,(H,23,26)
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 9.86E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))		BDBM322553
PNG
(US10183940, Example 6)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccnc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-11-24-19-9-4-3-7-16(18)19)25-21(26)17-8-5-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322563
PNG
(US10183940, Example 16)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccc(F)cc1
Show InChI InChI=1S/C19H21FN2O2/c1-19(2,14-6-8-15(20)9-7-14)22-18(23)16-5-3-4-13-12-21-10-11-24-17(13)16/h3-9,21H,10-12H2,1-2H3,(H,22,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322587
PNG
(US10183940, Example 39)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-14-7-5-9-16(22)17(14)26(3)25-19)24-20(27)15-8-4-6-13-12-23-10-11-28-18(13)15/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322606
PNG
(US10183940, Example 58)
Show SMILES Cc1cccn2c(ncc12)C1(CCOCC1)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C23H26N4O3/c1-16-4-3-10-27-19(16)15-25-22(27)23(7-11-29-12-8-23)26-21(28)18-6-2-5-17-14-24-9-13-30-20(17)18/h2-6,10,15,24H,7-9,11-14H2,1H3,(H,26,28)
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n/an/an/an/a 2.49E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322611
PNG
(US10183940, Example 61)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1nc(C2CC2)c2c(F)cccn12
Show InChI InChI=1S/C23H25FN4O2/c1-23(2,22-26-18(14-8-9-14)19-17(24)7-4-11-28(19)22)27-21(29)16-6-3-5-15-13-25-10-12-30-20(15)16/h3-7,11,14,25H,8-10,12-13H2,1-2H3,(H,27,29)
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n/an/an/an/a 6.30n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322626
PNG
(US10183940, Example 76)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C23H27N5O2/c1-14-5-4-11-28-19(14)17(15-6-7-15)26-22(28)23(2,3)27-21(29)18-20-16(8-9-25-18)13-24-10-12-30-20/h4-5,8-9,11,15,24H,6-7,10,12-13H2,1-3H3,(H,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322551
PNG
(US10183940, Example 4)
Show SMILES Clc1ccc2nc([nH]c2c1)C1(CC1)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C20H19ClN4O2/c21-13-4-5-15-16(10-13)24-19(23-15)20(6-7-20)25-18(26)14-3-1-2-12-11-22-8-9-27-17(12)14/h1-5,10,22H,6-9,11H2,(H,23,24)(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322559
PNG
(US10183940, Example 12)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1cccc2ncccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-9-4-10-19-16(18)8-5-11-24-19)25-21(26)17-7-3-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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n/an/an/an/a 98.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322575
PNG
(US10183940, Example 27)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C23H25N3O2/c1-15-17-8-4-5-9-18(17)20(14-25-15)23(2,3)26-22(27)19-10-6-7-16-13-24-11-12-28-21(16)19/h4-10,14,24H,11-13H2,1-3H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322580
PNG
(US10183940, Example 32)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23N3O3/c1-13-6-4-8-15-17(13)27-24-19(15)21(2,3)23-20(25)16-9-5-7-14-12-22-10-11-26-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322588
PNG
(US10183940, Example 40)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H26N4O2/c1-14-7-5-9-16-18(14)26(4)25-20(16)22(2,3)24-21(27)17-10-6-8-15-13-23-11-12-28-19(15)17/h5-10,23H,11-13H2,1-4H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322591
PNG
(US10183940, Example 43)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1n[nH]c2c(F)cccc12
Show InChI InChI=1S/C20H21FN4O2/c1-20(2,18-13-6-4-8-15(21)16(13)24-25-18)23-19(26)14-7-3-5-12-11-22-9-10-27-17(12)14/h3-8,22H,9-11H2,1-2H3,(H,23,26)(H,24,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322594
PNG
(US10183940, Example 46)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ncnc2ccccc12
Show InChI InChI=1S/C21H22N4O2/c1-21(2,19-15-7-3-4-9-17(15)23-13-24-19)25-20(26)16-8-5-6-14-12-22-10-11-27-18(14)16/h3-9,13,22H,10-12H2,1-2H3,(H,25,26)
PDB

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n/an/an/an/a 9.20n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322597
PNG
(US10183940, Example 49)
Show SMILES Cc1cccn2c(ncc12)C1(CC1)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H22N4O2/c1-14-4-3-10-25-17(14)13-23-20(25)21(7-8-21)24-19(26)16-6-2-5-15-12-22-9-11-27-18(15)16/h2-6,10,13,22H,7-9,11-12H2,1H3,(H,24,26)
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n/an/an/an/a 1.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322601
PNG
(US10183940, Example 53)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H26N4O2/c1-14-7-6-11-26-18(14)15(2)24-21(26)22(3,4)25-20(27)17-9-5-8-16-13-23-10-12-28-19(16)17/h5-9,11,23H,10,12-13H2,1-4H3,(H,25,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322603
PNG
(US10183940, Example 55)
Show SMILES Cc1cccn2c(ncc12)C(C)(NC(=O)c1cccc2CNCCOc12)C1CC1
Show InChI InChI=1S/C23H26N4O2/c1-15-5-4-11-27-19(15)14-25-22(27)23(2,17-8-9-17)26-21(28)18-7-3-6-16-13-24-10-12-29-20(16)18/h3-7,11,14,17,24H,8-10,12-13H2,1-2H3,(H,26,28)
PDB

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n/an/an/an/a 134n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322613
PNG
(US10183940, Example 63)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1nc(c2c(F)cccn12)C(F)(F)F
Show InChI InChI=1S/C21H20F4N4O2/c1-20(2,19-27-17(21(23,24)25)15-14(22)7-4-9-29(15)19)28-18(30)13-6-3-5-12-11-26-8-10-31-16(12)13/h3-7,9,26H,8,10-11H2,1-2H3,(H,28,30)
PDB

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n/an/an/an/a 32.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322620
PNG
(US10183940, Example 70)
Show SMILES Cc1cccn2c(cnc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(13-23-19(14)25)21(2,3)24-20(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322621
PNG
(US10183940, Example 71)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H25N3O2/c1-15-6-5-12-25-18(15)9-10-19(25)22(2,3)24-21(26)17-8-4-7-16-14-23-11-13-27-20(16)17/h4-10,12,23H,11,13-14H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322624
PNG
(US10183940, Example 74)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O3/c1-20(2,19-23-12-14-15(27-3)5-4-9-25(14)19)24-18(26)16-17-13(6-7-22-16)11-21-8-10-28-17/h4-7,9,12,21H,8,10-11H2,1-3H3,(H,24,26)
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n/an/an/an/a 106n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322549
PNG
(US10183940, Example 2)
Show SMILES CC(NC(=O)c1cccc2CNCCOc12)c1nc2ccccc2[nH]1
PDB

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n/an/an/an/a 302n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322552
PNG
(US10183940, Example 5)
Show SMILES Clc1ccc2nc([nH]c2c1)C1(CCOC1)NC(=O)c1cccc2CNCCOc12
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322553
PNG
(US10183940, Example 6)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccnc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-11-24-19-9-4-3-7-16(18)19)25-21(26)17-8-5-6-15-14-23-12-13-27-20(15)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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n/an/an/an/a 8.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322557
PNG
(US10183940, Example 10)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1cccc2cccnc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,18-10-4-6-15-8-5-11-24-19(15)18)25-21(26)17-9-3-7-16-14-23-12-13-27-20(16)17/h3-11,23H,12-14H2,1-2H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322567
PNG
(US10183940, Example 20)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-13-6-4-5-7-16(13)25(3)24-18)23-19(26)14-8-9-22-15-12-21-10-11-27-17(14)15/h4-9,21H,10-12H2,1-3H3,(H,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322569
PNG
(US10183940, Example 22)
Show SMILES Cn1nc(c2c(F)cccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-17-15(22)8-5-9-16(17)26(3)25-19)24-20(27)14-7-4-6-13-12-23-10-11-28-18(13)14/h4-9,23H,10-12H2,1-3H3,(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322576
PNG
(US10183940, Example 28)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C23H25N3O2/c1-15-13-16-7-4-5-9-18(16)21(25-15)23(2,3)26-22(27)19-10-6-8-17-14-24-11-12-28-20(17)19/h4-10,13,24H,11-12,14H2,1-3H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322579
PNG
(US10183940, Example 31)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-10-15-6-4-5-7-17(15)20(25-14)22(2,3)26-21(27)18-13-24-12-16-11-23-8-9-28-19(16)18/h4-7,10,12-13,23H,8-9,11H2,1-3H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322584
PNG
(US10183940, Example 36)
Show SMILES CC(C)(NC(=O)c1ccnc2CNCCOc12)c1noc2c(F)cccc12
Show InChI InChI=1S/C19H19FN4O3/c1-19(2,17-11-4-3-5-13(20)15(11)27-24-17)23-18(25)12-6-7-22-14-10-21-8-9-26-16(12)14/h3-7,21H,8-10H2,1-2H3,(H,23,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322590
PNG
(US10183940, Example 42)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-15-17(13)26(4)25-19(15)21(2,3)24-20(27)16-12-23-11-14-10-22-8-9-28-18(14)16/h5-7,11-12,22H,8-10H2,1-4H3,(H,24,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322599
PNG
(US10183940, Example 51)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O3/c1-21(2,20-23-13-16-17(27-3)8-5-10-25(16)20)24-19(26)15-7-4-6-14-12-22-9-11-28-18(14)15/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322604
PNG
(US10183940, Example 56)
Show SMILES CC(C)CC(C)(NC(=O)c1cccc2CNCCOc12)c1ncc2c(C)cccn12
Show InChI InChI=1S/C24H30N4O2/c1-16(2)13-24(4,23-26-15-20-17(3)7-6-11-28(20)23)27-22(29)19-9-5-8-18-14-25-10-12-30-21(18)19/h5-9,11,15-16,25H,10,12-14H2,1-4H3,(H,27,29)
PDB

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n/an/an/an/a 1.98E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322614
PNG
(US10183940, Example 64)
Show SMILES Cc1nc(c2ccccc2n1)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-24-18-10-5-4-8-16(18)20(25-14)22(2,3)26-21(27)17-9-6-7-15-13-23-11-12-28-19(15)17/h4-10,23H,11-13H2,1-3H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322616
PNG
(US10183940, Example 66)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ncnc2c(F)cccc12
Show InChI InChI=1S/C21H21FN4O2/c1-21(2,19-14-6-4-8-16(22)17(14)24-12-25-19)26-20(27)15-7-3-5-13-11-23-9-10-28-18(13)15/h3-8,12,23H,9-11H2,1-2H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322627
PNG
(US10183940, Example 77)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-5-4-11-25-16(14)6-7-17(25)21(2,3)24-20(26)18-19-15(8-9-23-18)13-22-10-12-27-19/h4-9,11,22H,10,12-13H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322628
PNG
(US10183940, Example 78 | US10183940, Example 79)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-13-5-4-9-25-16(13)12-23-19(25)20(2,3)24-18(26)14-6-7-22-15-11-21-8-10-27-17(14)15/h4-7,9,12,21H,8,10-11H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322555
PNG
(US10183940, Example 8)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O2/c1-19(2,13-6-7-15(20)16(21)10-13)23-18(24)14-5-3-4-12-11-22-8-9-25-17(12)14/h3-7,10,22H,8-9,11H2,1-2H3,(H,23,24)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322560
PNG
(US10183940, Example 13)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ncc2ccccn12
Show InChI InChI=1S/C20H22N4O2/c1-20(2,19-22-13-15-7-3-4-10-24(15)19)23-18(25)16-8-5-6-14-12-21-9-11-26-17(14)16/h3-8,10,13,21H,9,11-12H2,1-2H3,(H,23,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322561
PNG
(US10183940, Example 14)
Show SMILES CC(C)(COc1cnccc1C(F)(F)F)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C20H22F3N3O3/c1-19(2,12-29-16-11-24-7-6-15(16)20(21,22)23)26-18(27)14-5-3-4-13-10-25-8-9-28-17(13)14/h3-7,11,25H,8-10,12H2,1-2H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322570
PNG
(US10183940, Example 23)
Show SMILES Cn1nc(c2ccc(F)cc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-21(2,19-15-8-7-14(22)11-17(15)26(3)25-19)24-20(27)16-6-4-5-13-12-23-9-10-28-18(13)16/h4-8,11,23H,9-10,12H2,1-3H3,(H,24,27)
PDB

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n/an/an/an/a 0.900n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322578
PNG
(US10183940, Example 30)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-12-15-6-4-5-7-16(15)20(25-14)22(2,3)26-21(27)17-8-9-24-18-13-23-10-11-28-19(17)18/h4-9,12,23H,10-11,13H2,1-3H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322582
PNG
(US10183940, Example 34)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1noc2c(F)cccc12
Show InChI InChI=1S/C20H20FN3O3/c1-20(2,18-13-6-4-8-15(21)17(13)27-24-18)23-19(25)14-7-3-5-12-11-22-9-10-26-16(12)14/h3-8,22H,9-11H2,1-2H3,(H,23,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322598
PNG
(US10183940, Example 50)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-13-17-16(22)8-5-10-26(17)20(24-13)21(2,3)25-19(27)15-7-4-6-14-12-23-9-11-28-18(14)15/h4-8,10,23H,9,11-12H2,1-3H3,(H,25,27)
PDB

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n/an/an/an/a 2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322605
PNG
(US10183940, Example 57)
Show SMILES Cc1cccn2c(ncc12)C1(CCOC1)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O3/c1-15-4-3-9-26-18(15)13-24-21(26)22(7-10-28-14-22)25-20(27)17-6-2-5-16-12-23-8-11-29-19(16)17/h2-6,9,13,23H,7-8,10-12,14H2,1H3,(H,25,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322612
PNG
(US10183940, Example 62)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C24H28N4O2/c1-15-6-5-12-28-20(15)19(16-9-10-16)26-23(28)24(2,3)27-22(29)18-8-4-7-17-14-25-11-13-30-21(17)18/h4-8,12,16,25H,9-11,13-14H2,1-3H3,(H,27,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322622
PNG
(US10183940, Example 72)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-13-5-4-9-25-15(13)12-23-19(25)20(2,3)24-18(26)16-17-14(6-7-22-16)11-21-8-10-27-17/h4-7,9,12,21H,8,10-11H2,1-3H3,(H,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322625
PNG
(US10183940, Example 75)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-10-26-17(13)14(2)24-20(26)21(3,4)25-19(27)16-18-15(7-8-23-16)12-22-9-11-28-18/h5-8,10,22H,9,11-12H2,1-4H3,(H,25,27)
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n/an/an/an/a 10.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322565
PNG
(US10183940, Example 18)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-21(2,19-15-8-4-5-10-17(15)25(3)24-19)23-20(26)16-9-6-7-14-13-22-11-12-27-18(14)16/h4-10,22H,11-13H2,1-3H3,(H,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322571
PNG
(US10183940, Example 24)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-4-9-18-17(13-23-25(14)18)21(2,3)24-20(26)16-8-5-7-15-12-22-10-11-27-19(15)16/h4-9,13,22H,10-12H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322581
PNG
(US10183940, Example 33)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-13-6-4-8-15-17(13)24-25-19(15)21(2,3)23-20(26)16-9-5-7-14-12-22-10-11-27-18(14)16/h4-9,22H,10-12H2,1-3H3,(H,23,26)(H,24,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322592
PNG
(US10183940, Example 44)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1n[nH]c2c(Cl)cccc12
Show InChI InChI=1S/C20H21ClN4O2/c1-20(2,18-13-6-4-8-15(21)16(13)24-25-18)23-19(26)14-7-3-5-12-11-22-9-10-27-17(12)14/h3-8,22H,9-11H2,1-2H3,(H,23,26)(H,24,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322602
PNG
(US10183940, Example 54)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-15-5-3-11-26-18(15)14-24-21(26)22(8-4-9-22)25-20(27)17-7-2-6-16-13-23-10-12-28-19(16)17/h2-3,5-7,11,14,23H,4,8-10,12-13H2,1H3,(H,25,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322609
PNG
(US10183940, Example 59)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ncc2c(OC(F)(F)F)cccn12
Show InChI InChI=1S/C21H21F3N4O3/c1-20(2,19-26-12-15-16(31-21(22,23)24)7-4-9-28(15)19)27-18(29)14-6-3-5-13-11-25-8-10-30-17(13)14/h3-7,9,12,25H,8,10-11H2,1-2H3,(H,27,29)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322615
PNG
(US10183940, Example 65)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C23H26N4O2/c1-14-7-5-9-17-19(14)25-15(2)26-21(17)23(3,4)27-22(28)18-10-6-8-16-13-24-11-12-29-20(16)18/h5-10,24H,11-13H2,1-4H3,(H,27,28)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322619
PNG
(US10183940, Example 69)
Show SMILES Cc1nc2ccccn2c1C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-19(25-11-5-4-9-17(25)23-14)21(2,3)24-20(26)16-8-6-7-15-13-22-10-12-27-18(15)16/h4-9,11,22H,10,12-13H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322548
PNG
(US10183940, Example 1)
Show SMILES CC(C)(C)OC(=O)N(CCO)Cc1nccc(Br)c1F
Show InChI InChI=1S/C13H18BrFN2O3/c1-13(2,3)20-12(19)17(6-7-18)8-10-11(15)9(14)4-5-16-10/h4-5,18H,6-8H2,1-3H3
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322550
PNG
(US10183940, Example 3)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1nc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C20H21ClN4O2/c1-20(2,19-23-15-7-6-13(21)10-16(15)24-19)25-18(26)14-5-3-4-12-11-22-8-9-27-17(12)14/h3-7,10,22H,8-9,11H2,1-2H3,(H,23,24)(H,25,26)
PDB

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n/an/an/an/a 45.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322562
PNG
(US10183940, Example 15)
Show SMILES Cc1cccnc1OCC(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C20H25N3O3/c1-14-6-5-9-22-19(14)26-13-20(2,3)23-18(24)16-8-4-7-15-12-21-10-11-25-17(15)16/h4-9,21H,10-13H2,1-3H3,(H,23,24)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322595
PNG
(US10183940, Example 47)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H24N4O2/c1-14-6-5-10-25-17(14)13-23-20(25)21(2,3)24-19(26)16-8-4-7-15-12-22-9-11-27-18(15)16/h4-8,10,13,22H,9,11-12H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322610
PNG
(US10183940, Example 60)
Show SMILES C[C@H](NC(=O)c1cccc2CNCCOc12)c1ncc2c(C)cccn12 |r|
Show InChI InChI=1S/C20H22N4O2/c1-13-5-4-9-24-17(13)12-22-19(24)14(2)23-20(25)16-7-3-6-15-11-21-8-10-26-18(15)16/h3-7,9,12,14,21H,8,10-11H2,1-2H3,(H,23,25)/t14-/m0/s1
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322617
PNG
(US10183940, Example 67)
Show SMILES Cc1nc(c2cccc(F)c2n1)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H23FN4O2/c1-13-25-18-15(7-5-9-17(18)23)20(26-13)22(2,3)27-21(28)16-8-4-6-14-12-24-10-11-29-19(14)16/h4-9,24H,10-12H2,1-3H3,(H,27,28)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322618
PNG
(US10183940, Example 68)
Show SMILES Cc1cccn2c(nnc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-13-6-5-10-25-17(13)23-24-19(25)20(2,3)22-18(26)15-8-4-7-14-12-21-9-11-27-16(14)15/h4-8,10,21H,9,11-12H2,1-3H3,(H,22,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322628
PNG
(US10183940, Example 78 | US10183940, Example 79)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-13-5-4-9-25-16(13)12-23-19(25)20(2,3)24-18(26)14-6-7-22-15-11-21-8-10-27-17(14)15/h4-7,9,12,21H,8,10-11H2,1-3H3,(H,24,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322556
PNG
(US10183940, Example 9)
Show SMILES C[C@H](NC(=O)c1cccc2CNCCOc12)c1cccc2ccccc12 |r|
Show InChI InChI=1S/C22H22N2O2/c1-15(18-10-4-7-16-6-2-3-9-19(16)18)24-22(25)20-11-5-8-17-14-23-12-13-26-21(17)20/h2-11,15,23H,12-14H2,1H3,(H,24,25)/t15-/m0/s1
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322568
PNG
(US10183940, Example 21)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1cncc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-16(14)25(3)24-18)23-19(26)15-12-22-11-13-10-21-8-9-27-17(13)15/h4-7,11-12,21H,8-10H2,1-3H3,(H,23,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322577
PNG
(US10183940, Example 29)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-12-15-6-4-5-7-17(15)20(25-14)22(2,3)26-21(27)18-19-16(8-9-24-18)13-23-10-11-28-19/h4-9,12,23H,10-11,13H2,1-3H3,(H,26,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322593
PNG
(US10183940, Example 45)
Show SMILES Cc1cccc2c(ncnc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-6-4-8-16-18(14)24-13-25-20(16)22(2,3)26-21(27)17-9-5-7-15-12-23-10-11-28-19(15)17/h4-9,13,23H,10-12H2,1-3H3,(H,26,27)
PDB

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n/an/an/an/a 9.20n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322623
PNG
(US10183940, Example 73)
Show SMILES Cc1cccn2c(ncc12)C1(CC1)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H21N5O2/c1-13-3-2-9-25-15(13)12-23-19(25)20(5-6-20)24-18(26)16-17-14(4-7-22-16)11-21-8-10-27-17/h2-4,7,9,12,21H,5-6,8,10-11H2,1H3,(H,24,26)
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n/an/an/an/a 39.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322554
PNG
(US10183940, Example 7)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N2O2/c1-23(2,20-12-6-8-16-7-3-4-10-18(16)20)25-22(26)19-11-5-9-17-15-24-13-14-27-21(17)19/h3-12,24H,13-15H2,1-2H3,(H,25,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322558
PNG
(US10183940, Example 11)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1cccc2cnccc12
Show InChI InChI=1S/C22H23N3O2/c1-22(2,19-8-4-5-15-13-23-10-9-17(15)19)25-21(26)18-7-3-6-16-14-24-11-12-27-20(16)18/h3-10,13,24H,11-12,14H2,1-2H3,(H,25,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322564
PNG
(US10183940, Example 17)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2,14-6-8-15(20)9-7-14)22-18(23)16-5-3-4-13-12-21-10-11-24-17(13)16/h3-9,21H,10-12H2,1-2H3,(H,22,23)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322566
PNG
(US10183940, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1nccc2CNCCOc12
Show InChI InChI=1S/C20H23N5O2/c1-20(2,18-14-6-4-5-7-15(14)25(3)24-18)23-19(26)16-17-13(8-9-22-16)12-21-10-11-27-17/h4-9,21H,10-12H2,1-3H3,(H,23,26)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322572
PNG
(US10183940, Example 25)
Show SMILES Cn1nc(c2cccc(c12)C(F)(F)F)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H23F3N4O2/c1-21(2,19-14-7-5-9-16(22(23,24)25)17(14)29(3)28-19)27-20(30)15-8-4-6-13-12-26-10-11-31-18(13)15/h4-9,26H,10-12H2,1-3H3,(H,27,30)
PDB

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n/an/an/an/a 6.80n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322573
PNG
(US10183940, Example 26)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C22H24N4O2/c1-14-16-8-4-5-9-17(16)20(26-25-14)22(2,3)24-21(27)18-10-6-7-15-13-23-11-12-28-19(15)18/h4-10,23H,11-13H2,1-3H3,(H,24,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322583
PNG
(US10183940, Example 35)
Show SMILES CC(C)(NC(=O)c1nccc2CNCCOc12)c1noc2c(F)cccc12
Show InChI InChI=1S/C19H19FN4O3/c1-19(2,17-12-4-3-5-13(20)16(12)27-24-17)23-18(25)14-15-11(6-7-22-14)10-21-8-9-26-15/h3-7,21H,8-10H2,1-2H3,(H,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322585
PNG
(US10183940, Example 37)
Show SMILES CC(C)(NC(=O)c1cncc2CNCCOc12)c1noc2c(F)cccc12
Show InChI InChI=1S/C19H19FN4O3/c1-19(2,17-12-4-3-5-14(20)16(12)27-24-17)23-18(25)13-10-22-9-11-8-21-6-7-26-15(11)13/h3-5,9-10,21H,6-8H2,1-2H3,(H,23,25)
PDB

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n/an/an/an/a 1.60E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322586
PNG
(US10183940, Example 38)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C20H20ClN3O3/c1-20(2,18-13-6-4-8-15(21)17(13)27-24-18)23-19(25)14-7-3-5-12-11-22-9-10-26-16(12)14/h3-8,22H,9-11H2,1-2H3,(H,23,25)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322589
PNG
(US10183940, Example 41)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)c1ccnc2CNCCOc12
Show InChI InChI=1S/C21H25N5O2/c1-13-6-5-7-14-17(13)26(4)25-19(14)21(2,3)24-20(27)15-8-9-23-16-12-22-10-11-28-18(15)16/h5-9,22H,10-12H2,1-4H3,(H,24,27)
PDB

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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322596
PNG
(US10183940, Example 48)
Show SMILES CC(C)(NC(=O)c1cccc2CNCCOc12)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C20H21ClN4O2/c1-20(2,19-23-12-16-15(21)7-4-9-25(16)19)24-18(26)14-6-3-5-13-11-22-8-10-27-17(13)14/h3-7,9,12,22H,8,10-11H2,1-2H3,(H,24,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))		BDBM322600
PNG
(US10183940, Example 52)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)c1cccc2CNCCOc12
Show InChI InChI=1S/C21H23FN4O2/c1-13-9-15(22)12-26-17(13)11-24-20(26)21(2,3)25-19(27)16-6-4-5-14-10-23-7-8-28-18(14)16/h4-6,9,11-12,23H,7-8,10H2,1-3H3,(H,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...

US Patent US10183940 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5J45
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%