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USPatent US8653100

Compile Data Set for Download or QSAR

Found 267 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141249
PNG
(US8653100, 143)
Show SMILES CN(C)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c1-27(2)31(28,29)26-14-15-30-20-9-4-17-10-13-25-22(21(17)16-20)23(11-3-12-23)18-5-7-19(24)8-6-18/h4-9,16,22,25-26H,3,10-15H2,1-2H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141250
PNG
(US8653100, 144)
Show SMILES FC(F)(F)CCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H28ClF3N2O3S/c25-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-29-22)33-14-13-30-34(31,32)15-11-24(26,27)28/h2-7,16,22,29-30H,1,8-15H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141251
PNG
(US8653100, 145)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(C(C)c3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C22H29ClN2O3S/c1-3-14-29(26,27)25-12-13-28-20-9-6-18-10-11-24-22(21(18)15-20)16(2)17-4-7-19(23)8-5-17/h4-9,15-16,22,24-25H,3,10-14H2,1-2H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141263
PNG
(US8653100, 157)
Show SMILES Nc1cccc(c1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClN3O3S/c28-21-8-6-20(7-9-21)27(12-2-13-27)26-25-18-23(10-5-19(25)11-14-30-26)34-16-15-31-35(32,33)24-4-1-3-22(29)17-24/h1,3-10,17-18,26,30-31H,2,11-16,29H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141061
PNG
(US8653100, 15)
Show SMILES CCCS(=O)(=O)NCCOc1cc2C(NCCc2cc1F)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClFN2O3S/c1-2-14-32(29,30)28-12-13-31-22-16-20-17(15-21(22)26)8-11-27-23(20)24(9-3-10-24)18-4-6-19(25)7-5-18/h4-7,15-16,23,27-28H,2-3,8-14H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141134
PNG
(US8653100, 65)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(F)cc1
Show InChI InChI=1S/C24H31FN2O3S/c1-2-16-31(28,29)27-14-15-30-21-9-4-18-10-13-26-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h4-9,17,23,26-27H,2-3,10-16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141182
PNG
(US8653100, 93)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O2S/c1-29-15-22(27-16-29)32(30,31)28-14-17-3-4-18-9-12-26-23(21(18)13-17)24(10-2-11-24)19-5-7-20(25)8-6-19/h3-8,13,15-16,23,26,28H,2,9-12,14H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141184
PNG
(US8653100, 95)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1cccc(F)c1
Show InChI InChI=1S/C24H31FN2O3S/c1-2-15-31(28,29)27-13-14-30-21-8-7-18-9-12-26-23(22(18)17-21)24(10-4-11-24)19-5-3-6-20(25)16-19/h3,5-8,16-17,23,26-27H,2,4,9-15H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141200
PNG
(US8653100, 101)
Show SMILES Fc1cccc(c1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)c3cccnc3)cc12
Show InChI InChI=1S/C26H28FN3O3S/c27-21-5-1-4-20(16-21)26(10-3-11-26)25-24-17-22(8-7-19(24)9-13-29-25)33-15-14-30-34(31,32)23-6-2-12-28-18-23/h1-2,4-8,12,16-18,25,29-30H,3,9-11,13-15H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141202
PNG
(US8653100, 103)
Show SMILES CC(C)(O)CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H33ClN2O4S/c1-24(2,29)17-33(30,31)28-14-15-32-21-9-4-18-10-13-27-23(22(18)16-21)25(11-3-12-25)19-5-7-20(26)8-6-19/h4-9,16,23,27-29H,3,10-15,17H2,1-2H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141255
PNG
(US8653100, 149)
Show SMILES CN(C)CCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN3O3S/c1-29(2)15-17-33(30,31)28-14-16-32-22-9-4-19-10-13-27-24(23(19)18-22)25(11-3-12-25)20-5-7-21(26)8-6-20/h4-9,18,24,27-28H,3,10-17H2,1-2H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141254
PNG
(US8653100, 148 | US8653100, 151 | US8653100, 159 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCNC3)cc12
Show InChI InChI=1S/C25H32ClN3O3S/c26-20-5-3-19(4-6-20)25(10-1-11-25)24-23-16-21(7-2-18(23)8-13-28-24)32-15-14-29-33(30,31)22-9-12-27-17-22/h2-7,16,22,24,27-29H,1,8-15,17H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141072
PNG
(US8653100, 28)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CC3)cc12
Show InChI InChI=1S/C24H29ClN2O3S/c25-19-5-3-18(4-6-19)24(11-1-12-24)23-22-16-20(7-2-17(22)10-13-26-23)30-15-14-27-31(28,29)21-8-9-21/h2-7,16,21,23,26-27H,1,8-15H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141183
PNG
(US8653100, 94)
Show SMILES FCCCS(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H28ClFN2O2S/c24-20-7-5-19(6-8-20)23(10-1-11-23)22-21-15-17(3-4-18(21)9-13-26-22)16-27-30(28,29)14-2-12-25/h3-8,15,22,26-27H,1-2,9-14,16H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141199
PNG
(US8653100, 100)
Show SMILES Cn1cc(cn1)S(=O)(=O)NCc1ccc2CCNC(c2c1)C(C)(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H27ClN4O2S/c1-23(2,18-6-8-19(24)9-7-18)22-21-12-16(4-5-17(21)10-11-25-22)13-27-31(29,30)20-14-26-28(3)15-20/h4-9,12,14-15,22,25,27H,10-11,13H2,1-3H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141246
PNG
(US8653100, 140)
Show SMILES FCCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClFN2O3S/c25-20-6-4-19(5-7-20)24(10-1-11-24)23-22-17-21(8-3-18(22)9-13-27-23)31-15-14-28-32(29,30)16-2-12-26/h3-8,17,23,27-28H,1-2,9-16H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141254
PNG
(US8653100, 148 | US8653100, 151 | US8653100, 159 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCNC3)cc12
Show InChI InChI=1S/C25H32ClN3O3S/c26-20-5-3-19(4-6-20)25(10-1-11-25)24-23-16-21(7-2-18(23)8-13-28-24)32-15-14-29-33(30,31)22-9-12-27-17-22/h2-7,16,22,24,27-29H,1,8-15,17H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141180
PNG
(US8653100, 91)
Show SMILES Cn1cc(cn1)S(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O2S/c1-29-16-21(15-27-29)32(30,31)28-14-17-3-4-18-9-12-26-23(22(18)13-17)24(10-2-11-24)19-5-7-20(25)8-6-19/h3-8,13,15-16,23,26,28H,2,9-12,14H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141254
PNG
(US8653100, 148 | US8653100, 151 | US8653100, 159 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCNC3)cc12
Show InChI InChI=1S/C25H32ClN3O3S/c26-20-5-3-19(4-6-20)25(10-1-11-25)24-23-16-21(7-2-18(23)8-13-28-24)32-15-14-29-33(30,31)22-9-12-27-17-22/h2-7,16,22,24,27-29H,1,8-15,17H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141262
PNG
(US8653100, 156)
Show SMILES COc1ccc(cn1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClN3O4S/c1-34-25-10-9-23(18-30-25)36(32,33)31-15-16-35-22-8-3-19-11-14-29-26(24(19)17-22)27(12-2-13-27)20-4-6-21(28)7-5-20/h3-10,17-18,26,29,31H,2,11-16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141060
PNG
(US8653100, 14)
Show SMILES Fc1cc2CCNC(c2cc1OCCNS(=O)(=O)c1cccnc1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClFN3O3S/c27-20-6-4-19(5-7-20)26(9-2-10-26)25-22-16-24(23(28)15-18(22)8-12-30-25)34-14-13-31-35(32,33)21-3-1-11-29-17-21/h1,3-7,11,15-17,25,30-31H,2,8-10,12-14H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141062
PNG
(US8653100, 16)
Show SMILES CCCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H33ClN2O3S/c1-2-3-17-32(29,30)28-15-16-31-22-10-5-19-11-14-27-24(23(19)18-22)25(12-4-13-25)20-6-8-21(26)9-7-20/h5-10,18,24,27-28H,2-4,11-17H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141179
PNG
(US8653100, 90)
Show SMILES CCCS(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O2S/c1-2-14-29(27,28)26-16-17-4-5-18-10-13-25-22(21(18)15-17)23(11-3-12-23)19-6-8-20(24)9-7-19/h4-9,15,22,25-26H,2-3,10-14,16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141261
PNG
(US8653100, 155)
Show SMILES CC(C)(C)CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H35ClN2O3S/c1-25(2,3)18-33(30,31)29-15-16-32-22-10-5-19-11-14-28-24(23(19)17-22)26(12-4-13-26)20-6-8-21(27)9-7-20/h5-10,17,24,28-29H,4,11-16,18H2,1-3H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141042
PNG
(US8653100, 2)
Show SMILES CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H27ClN2O3S/c1-29(26,27)25-13-14-28-19-8-3-16-9-12-24-21(20(16)15-19)22(10-2-11-22)17-4-6-18(23)7-5-17/h3-8,15,21,24-25H,2,9-14H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141178
PNG
(US8653100, 89)
Show SMILES CCCS(=O)(=O)NCCNc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN3O2S/c1-2-16-31(29,30)28-15-14-26-21-9-4-18-10-13-27-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h4-9,17,23,26-28H,2-3,10-16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141203
PNG
(US8653100, 104)
Show SMILES FCCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccccn1
Show InChI InChI=1S/C23H30FN3O3S/c24-11-4-16-31(28,29)27-14-15-30-19-7-6-18-8-13-26-22(20(18)17-19)23(9-3-10-23)21-5-1-2-12-25-21/h1-2,5-7,12,17,22,26-27H,3-4,8-11,13-16H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141245
PNG
(US8653100, 139)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C(C)(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H31ClN2O3S/c1-4-15-30(27,28)26-13-14-29-20-10-5-17-11-12-25-22(21(17)16-20)23(2,3)18-6-8-19(24)9-7-18/h5-10,16,22,25-26H,4,11-15H2,1-3H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141256
PNG
(US8653100, 150)
Show SMILES Nc1ncc(cn1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H28ClN5O3S/c26-19-5-3-18(4-6-19)25(9-1-10-25)23-22-14-20(7-2-17(22)8-11-28-23)34-13-12-31-35(32,33)21-15-29-24(27)30-16-21/h2-7,14-16,23,28,31H,1,8-13H2,(H2,27,29,30)
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141044
PNG
(US8653100, 4)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O3S/c1-2-16-31(28,29)27-14-15-30-21-9-4-18-10-13-26-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h4-9,17,23,26-27H,2-3,10-16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141048
PNG
(US8653100, 8)
Show SMILES CC(C)CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H33ClN2O3S/c1-18(2)17-32(29,30)28-14-15-31-22-9-4-19-10-13-27-24(23(19)16-22)25(11-3-12-25)20-5-7-21(26)8-6-20/h4-9,16,18,24,27-28H,3,10-15,17H2,1-2H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141201
PNG
(US8653100, 102)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1ccc2CCNC(c2c1)C(C)(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H27ClN4O2S/c1-23(2,18-6-8-19(24)9-7-18)22-20-12-16(4-5-17(20)10-11-25-22)13-27-31(29,30)21-14-28(3)15-26-21/h4-9,12,14-15,22,25,27H,10-11,13H2,1-3H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141102
PNG
(US8653100, 138 | US8653100, 168 | US8653100, 43)
Show SMILES Cn1cc(cn1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CC(F)(F)C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27ClF2N4O3S/c1-32-14-21(13-30-32)36(33,34)31-10-11-35-20-7-2-17-8-9-29-23(22(17)12-20)24(15-25(27,28)16-24)18-3-5-19(26)6-4-18/h2-7,12-14,23,29,31H,8-11,15-16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141248
PNG
(US8653100, 142)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)c(N)c1
Show InChI InChI=1S/C24H32ClN3O3S/c1-2-14-32(29,30)28-12-13-31-19-6-4-17-8-11-27-23(20(17)16-19)24(9-3-10-24)18-5-7-21(25)22(26)15-18/h4-7,15-16,23,27-28H,2-3,8-14,26H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141259
PNG
(US8653100, 153)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)c3cn[nH]c3)cc12
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141126
PNG
(US8653100, 160 | US8653100, 164 | US8653100, 192 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCCNC3)cc12
Show InChI InChI=1S/C26H34ClN3O3S/c27-21-7-5-20(6-8-21)26(11-2-12-26)25-24-17-22(9-4-19(24)10-14-29-25)33-16-15-30-34(31,32)23-3-1-13-28-18-23/h4-9,17,23,25,28-30H,1-3,10-16,18H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141049
PNG
(US8653100, 10 | US8653100, 141 | US8653100, 182 | ...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)c3cccnc3)cc12
Show InChI InChI=1S/C26H28ClN3O3S/c27-21-7-5-20(6-8-21)26(11-2-12-26)25-24-17-22(9-4-19(24)10-14-29-25)33-16-15-30-34(31,32)23-3-1-13-28-18-23/h1,3-9,13,17-18,25,29-30H,2,10-12,14-16H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141177
PNG
(US8653100, 88)
Show SMILES C\C=C\S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H29ClN2O3S/c1-2-16-31(28,29)27-14-15-30-21-9-4-18-10-13-26-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h2,4-9,16-17,23,26-27H,3,10-15H2,1H3/b16-2+
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141185
PNG
(US8653100, 96)
Show SMILES CCCS(=O)(=O)NCc1ccc2CCNC(c2c1)C(C)(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H29ClN2O2S/c1-4-13-28(26,27)25-15-16-5-6-17-11-12-24-21(20(17)14-16)22(2,3)18-7-9-19(23)10-8-18/h5-10,14,21,24-25H,4,11-13,15H2,1-3H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141186
PNG
(US8653100, 97)
Show SMILES OCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O4S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-11-25-22)30-14-12-26-31(28,29)15-13-27/h2-7,16,22,25-27H,1,8-15H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141187
PNG
(US8653100, 182 | US8653100, 98)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccccn1
Show InChI InChI=1S/C23H31N3O3S/c1-2-16-30(27,28)26-14-15-29-19-8-7-18-9-13-25-22(20(18)17-19)23(10-5-11-23)21-6-3-4-12-24-21/h3-4,6-8,12,17,22,25-26H,2,5,9-11,13-16H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141253
PNG
(US8653100, 147)
Show SMILES Nc1ccc(cc1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClN3O3S/c28-21-5-3-20(4-6-21)27(13-1-14-27)26-25-18-23(9-2-19(25)12-15-30-26)34-17-16-31-35(32,33)24-10-7-22(29)8-11-24/h2-11,18,26,30-31H,1,12-17,29H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141047
PNG
(US8653100, 7)
Show SMILES CCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O3S/c1-2-30(27,28)26-14-15-29-20-9-4-17-10-13-25-22(21(17)16-20)23(11-3-12-23)18-5-7-19(24)8-6-18/h4-9,16,22,25-26H,2-3,10-15H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141181
PNG
(US8653100, 92)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(cc12)C#N
Show InChI InChI=1S/C20H19ClN2/c21-17-6-4-16(5-7-17)20(9-1-10-20)19-18-12-14(13-22)2-3-15(18)8-11-23-19/h2-7,12,19,23H,1,8-11H2
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141198
PNG
(US8653100, 99)
Show SMILES CCCS(=O)(=O)NCC(=O)Nc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClN3O3S/c1-2-14-32(30,31)27-16-22(29)28-20-9-4-17-10-13-26-23(21(17)15-20)24(11-3-12-24)18-5-7-19(25)8-6-18/h4-9,15,23,26-27H,2-3,10-14,16H2,1H3,(H,28,29)
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM141196
PNG
(US8653100, 105 | US8653100, 191)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1cccc(Cl)n1
Show InChI InChI=1S/C23H30ClN3O3S/c1-2-15-31(28,29)26-13-14-30-18-8-7-17-9-12-25-22(19(17)16-18)23(10-4-11-23)20-5-3-6-21(24)27-20/h3,5-8,16,22,25-26H,2,4,9-15H2,1H3
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<100n/an/an/an/an/an/a7.5n/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...

US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%