Found 15 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160321
(US9040693, 22)Show SMILES OC(=O)c1scc2[nH]c(=O)n(-c3cc(ccc3Cl)S(=O)(=O)N3CCCc4ccccc34)c(=O)c12 |(-8.56,-1.78,;-7.02,-1.78,;-6.25,-3.11,;-6.25,-.44,;-7.15,.8,;-6.25,2.05,;-4.78,1.57,;-3.45,2.34,;-2.11,1.57,;-.78,2.34,;-2.11,.03,;-.78,-.74,;.55,.03,;1.89,-.74,;1.89,-2.28,;.55,-3.05,;-.78,-2.28,;-2.11,-3.05,;3.22,.03,;2.45,1.37,;3.99,-1.3,;4.55,.8,;4.55,2.34,;5.89,3.11,;7.22,2.34,;7.22,.8,;8.56,.03,;8.56,-1.51,;7.22,-2.28,;5.89,-1.51,;5.89,.03,;-3.45,-.74,;-3.45,-2.28,;-4.78,.03,)| Show InChI InChI=1S/C22H16ClN3O6S2/c23-14-8-7-13(34(31,32)25-9-3-5-12-4-1-2-6-16(12)25)10-17(14)26-20(27)18-15(24-22(26)30)11-33-19(18)21(28)29/h1-2,4,6-8,10-11H,3,5,9H2,(H,24,30)(H,28,29) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160326
(US9040693, 146)Show SMILES CC(C)(C(=O)c1ccc(Cl)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O)c1ccccc1 |(4.39,-1.92,;4.39,-.38,;3.62,.95,;3.06,.39,;3.06,1.93,;1.72,-.38,;1.72,-1.92,;.39,-2.69,;-.94,-1.92,;-2.28,-2.69,;-.94,-.38,;.39,.39,;-2.28,.39,;-2.28,1.93,;-.94,2.7,;-3.61,2.7,;-4.94,1.93,;-6.41,2.4,;-7.31,1.16,;-6.41,-.09,;-6.89,-1.55,;-8.39,-1.87,;-5.85,-2.7,;-4.94,.39,;-3.61,-.38,;-3.61,-1.92,;5.72,.39,;7.06,-.38,;8.39,.39,;8.39,1.93,;7.06,2.7,;5.72,1.93,)| Show InChI InChI=1S/C23H17ClN2O5S/c1-23(2,13-6-4-3-5-7-13)19(27)12-8-9-14(24)16(10-12)26-20(28)17-15(25-22(26)31)11-32-18(17)21(29)30/h3-11H,1-2H3,(H,25,31)(H,29,30) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160329
(US9040693, 233)Show SMILES COc1cc(F)c(cc1OCc1c(OC)ccc(F)c1F)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(4.34,-2.69,;3.01,-3.47,;1.68,-2.69,;.34,-3.47,;-.99,-2.69,;-2.33,-3.47,;-.99,-1.15,;.34,-.38,;1.68,-1.15,;3.01,-.38,;4.34,-1.15,;5.68,-.38,;7.01,-1.15,;7.01,-2.69,;5.68,-3.46,;8.34,-.38,;8.34,1.15,;7.01,1.93,;7.01,3.47,;5.68,1.15,;4.34,1.93,;-2.33,-.38,;-2.33,1.15,;-.99,1.93,;-3.66,1.93,;-4.99,1.15,;-6.46,1.63,;-7.36,.38,;-6.46,-.86,;-6.86,-2.35,;-8.34,-2.75,;-5.77,-3.44,;-4.99,-.38,;-3.66,-1.15,;-3.66,-2.69,)| Show InChI InChI=1S/C22H15F3N2O7S/c1-32-14-4-3-10(23)18(25)9(14)7-34-16-6-13(11(24)5-15(16)33-2)27-20(28)17-12(26-22(27)31)8-35-19(17)21(29)30/h3-6,8H,7H2,1-2H3,(H,26,31)(H,29,30) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160330
(US9040693, 367)Show SMILES COCCOc1ccc(F)c(F)c1COc1ccc(F)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(10.34,-2.69,;9.01,-3.46,;7.68,-2.69,;6.34,-3.46,;5.01,-2.69,;5.01,-1.15,;6.34,-.38,;6.34,1.16,;5.01,1.93,;5.01,3.47,;3.68,1.16,;2.34,1.93,;3.68,-.38,;2.34,-1.15,;1.01,-.38,;-.33,-1.15,;-.33,-2.69,;-1.66,-3.47,;-2.99,-2.69,;-4.33,-3.47,;-2.99,-1.15,;-1.66,-.38,;-4.33,-.38,;-4.33,1.15,;-2.99,1.93,;-5.66,1.93,;-6.99,1.15,;-8.46,1.63,;-9.36,.38,;-8.46,-.86,;-8.86,-2.35,;-10.34,-2.75,;-7.77,-3.44,;-6.99,-.38,;-5.66,-1.15,;-5.66,-2.69,)| Show InChI InChI=1S/C23H17F3N2O7S/c1-33-6-7-34-17-5-4-14(25)19(26)12(17)9-35-11-2-3-13(24)16(8-11)28-21(29)18-15(27-23(28)32)10-36-20(18)22(30)31/h2-5,8,10H,6-7,9H2,1H3,(H,27,32)(H,30,31) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160327
(US9040693, 191)Show SMILES COc1ccc(F)cc1C(C)(C)Sc1ccc(F)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(5.72,-3.46,;7.06,-2.69,;7.06,-1.15,;8.39,-.38,;8.39,1.16,;7.06,1.93,;7.06,3.47,;5.72,1.16,;5.72,-.38,;4.39,-1.15,;4.39,-2.69,;3.62,.18,;3.06,-.38,;1.72,-1.15,;1.72,-2.69,;.39,-3.46,;-.94,-2.69,;-2.28,-3.46,;-.94,-1.15,;.39,-.38,;-2.28,-.38,;-2.28,1.16,;-.94,1.93,;-3.61,1.93,;-4.94,1.16,;-6.41,1.63,;-7.31,.39,;-6.41,-.86,;-6.89,-2.32,;-8.39,-2.64,;-5.85,-3.47,;-4.94,-.38,;-3.61,-1.15,;-3.61,-2.69,)| Show InChI InChI=1S/C23H18F2N2O5S2/c1-23(2,13-8-11(24)4-7-17(13)32-3)34-12-5-6-14(25)16(9-12)27-20(28)18-15(26-22(27)31)10-33-19(18)21(29)30/h4-10H,1-3H3,(H,26,31)(H,29,30) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160325
(US9040693, 95)Show SMILES CN(C(=O)c1ccc(Cl)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O)c1ccccc1 |(4.55,-1.89,;4.55,-.35,;3.22,.42,;3.22,1.96,;1.89,-.35,;1.89,-1.89,;.55,-2.66,;-.78,-1.89,;-2.11,-2.66,;-.78,-.35,;.55,.42,;-2.11,.42,;-2.11,1.96,;-.78,2.73,;-3.45,2.73,;-4.78,1.96,;-6.25,2.43,;-7.15,1.19,;-6.25,-.06,;-7.02,-1.39,;-8.56,-1.39,;-6.25,-2.73,;-4.78,.42,;-3.45,-.35,;-3.45,-1.89,;5.89,.42,;7.22,-.35,;8.56,.42,;8.56,1.96,;7.22,2.73,;5.89,1.96,)| Show InChI InChI=1S/C21H14ClN3O5S/c1-24(12-5-3-2-4-6-12)18(26)11-7-8-13(22)15(9-11)25-19(27)16-14(23-21(25)30)10-31-17(16)20(28)29/h2-10H,1H3,(H,23,30)(H,28,29) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160328
(US9040693, 202)Show SMILES CC(C)(c1ccccc1)S(=O)(=O)c1ccc(F)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(4.34,2.69,;4.34,1.15,;4.74,-.33,;5.68,.38,;5.68,-1.15,;7.01,-1.93,;8.34,-1.15,;8.34,.38,;7.01,1.15,;3.01,.38,;2.24,1.72,;3.78,-.95,;1.68,-.38,;1.68,-1.93,;.34,-2.69,;-.99,-1.93,;-2.33,-2.69,;-.99,-.38,;.34,.38,;-2.33,.38,;-2.33,1.93,;-.99,2.69,;-3.66,2.69,;-4.99,1.93,;-6.46,2.4,;-7.36,1.15,;-6.46,-.09,;-6.86,-1.58,;-8.34,-1.98,;-5.77,-2.67,;-4.99,.38,;-3.66,-.38,;-3.66,-1.93,)| Show InChI InChI=1S/C22H17FN2O6S2/c1-22(2,12-6-4-3-5-7-12)33(30,31)13-8-9-14(23)16(10-13)25-19(26)17-15(24-21(25)29)11-32-18(17)20(27)28/h3-11H,1-2H3,(H,24,29)(H,27,28) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 37 |
KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160324
(US9040693, 48)Show SMILES COc1cccc(F)c1C(C)Oc1ccc(F)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(5.89,-2.66,;7.22,-1.89,;7.22,-.35,;8.56,.42,;8.56,1.96,;7.22,2.73,;5.89,1.96,;4.55,2.73,;5.89,.42,;4.55,-.35,;4.55,-1.89,;3.22,.42,;1.89,-.35,;1.89,-1.89,;.55,-2.66,;-.78,-1.89,;-2.11,-2.66,;-.78,-.35,;.55,.42,;-2.11,.42,;-2.11,1.96,;-.78,2.73,;-3.45,2.73,;-4.78,1.96,;-6.25,2.43,;-7.15,1.19,;-6.25,-.06,;-7.02,-1.39,;-8.56,-1.39,;-6.25,-2.73,;-4.78,.42,;-3.45,-.35,;-3.45,-1.89,)| | PDB
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| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | 37 |
KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160332
(US9040693, 420)Show SMILES COc1cc(F)c(cc1CN(C)c1c(F)cccc1F)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(3.01,-3.46,;3.01,-1.92,;1.68,-1.16,;.34,-1.93,;-.99,-1.16,;-2.33,-1.93,;-.99,.38,;.34,1.15,;1.68,.38,;3.01,1.15,;4.34,.38,;4.34,-1.15,;5.68,1.15,;5.68,2.69,;4.34,3.46,;7.01,3.46,;8.34,2.69,;8.34,1.15,;7.01,.38,;7.01,-1.16,;-2.33,1.15,;-2.33,2.69,;-.99,3.46,;-3.66,3.46,;-4.99,2.69,;-6.46,3.17,;-7.36,1.92,;-6.46,.68,;-6.86,-.81,;-8.34,-1.21,;-5.77,-1.9,;-4.99,1.15,;-3.66,.38,;-3.66,-1.16,)| Show InChI InChI=1S/C22H16F3N3O5S/c1-27(18-11(23)4-3-5-12(18)24)8-10-6-15(13(25)7-16(10)33-2)28-20(29)17-14(26-22(28)32)9-34-19(17)21(30)31/h3-7,9H,8H2,1-2H3,(H,26,32)(H,30,31) | PDB
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| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | 37 |
KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160331
(US9040693, 414)Show SMILES COc1cc(F)c(cc1COc1c(OC)ccc(F)c1F)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(4.34,-2.69,;3.01,-3.47,;1.68,-2.69,;.34,-3.47,;-.99,-2.69,;-2.33,-3.47,;-.99,-1.15,;.34,-.38,;1.68,-1.15,;3.01,-.38,;4.34,-1.15,;5.68,-.38,;7.01,-1.15,;7.01,-2.69,;8.34,-3.47,;8.34,-.38,;8.34,1.15,;7.01,1.93,;7.01,3.47,;5.68,1.15,;4.34,1.93,;-2.33,-.38,;-2.33,1.15,;-.99,1.93,;-3.66,1.93,;-4.99,1.15,;-6.46,1.63,;-7.36,.38,;-6.46,-.86,;-6.86,-2.35,;-8.34,-2.75,;-5.77,-3.44,;-4.99,-.38,;-3.66,-1.15,;-3.66,-2.69,)| Show InChI InChI=1S/C22H15F3N2O7S/c1-32-14-4-3-10(23)17(25)18(14)34-7-9-5-13(11(24)6-15(9)33-2)27-20(28)16-12(26-22(27)31)8-35-19(16)21(29)30/h3-6,8H,7H2,1-2H3,(H,26,31)(H,29,30) | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | 37 |
KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160319
(US9040693, 3)Show SMILES Clc1ccc(cc1-n1c(=O)[nH]c2sccc2c1=O)S(=O)(=O)N1CCCc2ccccc12 |(-2.82,-3.08,;-1.48,-2.31,;-.15,-3.08,;1.18,-2.31,;1.18,-.77,;-.15,,;-1.48,-.77,;-2.82,,;-2.82,1.54,;-1.48,2.31,;-4.15,2.31,;-5.48,1.54,;-6.95,2.02,;-7.85,.77,;-6.95,-.48,;-5.48,,;-4.15,-.77,;-4.15,-2.31,;2.52,,;1.75,1.33,;3.29,-1.33,;3.85,.77,;3.85,2.31,;5.19,3.08,;6.52,2.31,;6.52,.77,;7.85,,;7.85,-1.54,;6.52,-2.31,;5.19,-1.54,;5.19,,)| Show InChI InChI=1S/C21H16ClN3O4S2/c22-16-8-7-14(31(28,29)24-10-3-5-13-4-1-2-6-17(13)24)12-18(16)25-20(26)15-9-11-30-19(15)23-21(25)27/h1-2,4,6-9,11-12H,3,5,10H2,(H,23,27) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | 37 |
KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160322
(US9040693, 25)Show SMILES Cc1ccccc1COc1ccc(Cl)c(c1)-n1c(=O)[nH]c2csc(C(O)=O)c2c1=O |(7.22,-1.89,;7.22,-.35,;8.56,.42,;8.56,1.96,;7.22,2.73,;5.89,1.96,;5.89,.42,;4.55,-.35,;3.22,.42,;1.89,-.35,;1.89,-1.89,;.55,-2.66,;-.78,-1.89,;-2.11,-2.66,;-.78,-.35,;.55,.42,;-2.11,.42,;-2.11,1.96,;-.78,2.73,;-3.45,2.73,;-4.78,1.96,;-6.25,2.43,;-7.15,1.19,;-6.25,-.06,;-7.02,-1.39,;-8.56,-1.39,;-6.25,-2.73,;-4.78,.42,;-3.45,-.35,;-3.45,-1.89,)| Show InChI InChI=1S/C21H15ClN2O5S/c1-11-4-2-3-5-12(11)9-29-13-6-7-14(22)16(8-13)24-19(25)17-15(23-21(24)28)10-30-18(17)20(26)27/h2-8,10H,9H2,1H3,(H,23,28)(H,26,27) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160320
(US9040693, 17)Show SMILES CN(c1cccc(C)c1)S(=O)(=O)c1ccc(Cl)c(c1)-n1c(=O)[nH]c2sccc2c1=O |(3.19,2.69,;3.19,1.15,;4.52,.38,;4.52,-1.15,;5.85,-1.93,;7.19,-1.15,;7.19,.38,;8.52,1.15,;5.85,1.16,;1.85,.38,;2.62,-.95,;1.08,1.72,;.52,-.38,;.52,-1.93,;-.82,-2.69,;-2.15,-1.93,;-3.48,-2.69,;-2.15,-.38,;-.82,.38,;-3.48,.38,;-3.48,1.93,;-2.15,2.69,;-4.82,2.69,;-6.15,1.93,;-7.61,2.4,;-8.52,1.15,;-7.61,-.09,;-6.15,.38,;-4.82,-.38,;-4.82,-1.93,)| Show InChI InChI=1S/C20H16ClN3O4S2/c1-12-4-3-5-13(10-12)23(2)30(27,28)14-6-7-16(21)17(11-14)24-19(25)15-8-9-29-18(15)22-20(24)26/h3-11H,1-2H3,(H,22,26) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160318
(US9040693, 2)Show SMILES Clc1ccc(cc1-n1c(=O)[nH]c2ccsc2c1=O)S(=O)(=O)N1CCCc2ccccc12 |(-2.82,-3.08,;-1.48,-2.31,;-.15,-3.08,;1.18,-2.31,;1.18,-.77,;-.15,,;-1.48,-.77,;-2.82,,;-2.82,1.54,;-1.48,2.31,;-4.15,2.31,;-5.48,1.54,;-6.95,2.02,;-7.85,.77,;-6.95,-.48,;-5.48,,;-4.15,-.77,;-4.15,-2.31,;2.52,,;1.75,1.33,;3.29,-1.33,;3.85,.77,;3.85,2.31,;5.19,3.08,;6.52,2.31,;6.52,.77,;7.85,,;7.85,-1.54,;6.52,-2.31,;5.19,-1.54,;5.19,,)| Show InChI InChI=1S/C21H16ClN3O4S2/c22-15-8-7-14(31(28,29)24-10-3-5-13-4-1-2-6-17(13)24)12-18(15)25-20(26)19-16(9-11-30-19)23-21(25)27/h1-2,4,6-9,11-12H,3,5,10H2,(H,23,27) | PDB
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KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM160323
(US9040693, 31)Show SMILES CNC(=O)c1scc2[nH]c(=O)n(-c3cc(ccc3Cl)S(=O)(=O)N3CCCc4ccccc34)c(=O)c12 |(-8.94,-.44,;-8.17,-1.78,;-6.63,-1.78,;-5.86,-3.11,;-5.86,-.44,;-6.77,.8,;-5.86,2.05,;-4.4,1.57,;-3.06,2.34,;-1.73,1.57,;-.39,2.34,;-1.73,.03,;-.39,-.74,;.94,.03,;2.27,-.74,;2.27,-2.28,;.94,-3.05,;-.39,-2.28,;-1.73,-3.05,;3.61,.03,;2.84,1.37,;4.38,-1.3,;4.94,.8,;4.94,2.34,;6.27,3.11,;7.61,2.34,;7.61,.8,;8.94,.03,;8.94,-1.51,;7.61,-2.28,;6.27,-1.51,;6.27,.03,;-3.06,-.74,;-3.06,-2.28,;-4.4,.03,)| Show InChI InChI=1S/C23H19ClN4O5S2/c1-25-21(29)20-19-16(12-34-20)26-23(31)28(22(19)30)18-11-14(8-9-15(18)24)35(32,33)27-10-4-6-13-5-2-3-7-17(13)27/h2-3,5,7-9,11-12H,4,6,10H2,1H3,(H,25,29)(H,26,31) | PDB
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| n/a | n/a | 272 | n/a | n/a | n/a | n/a | n/a | 37 |
KISSEI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description
Antagonizing effect of compounds for human GnRHR1 was evaluated by change of calcium levels in GnRH-stimulated cells. After removing the culture medi... |
US Patent US9040693 (2015)
BindingDB Entry DOI: 10.7270/Q21R6P8N |
More data for this
Ligand-Target Pair | |
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