Found 14 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM200638
(US9227977, Compound (I))Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)n(Cc3ccccc3C(F)(F)F)c(=O)c12 Show InChI InChI=1S/C36H31F4N7O5/c1-50-12-13-52-15-14-51-11-5-8-22-7-4-10-28-30(22)35(49)46(19-23-6-2-3-9-27(23)36(38,39)40)29(44-28)20-47-34-31(33(41)42-21-43-34)32(45-47)24-16-25(37)18-26(48)17-24/h2-4,6-7,9-10,16-18,21,48H,11-15,19-20H2,1H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM200640
(US9227977, Example 50)Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)n(Cc3ccccc3F)c(=O)c12 Show InChI InChI=1S/C35H32FN7O5/c1-46-15-16-48-18-17-47-14-6-10-23-8-5-13-28-30(23)35(45)42(20-25-7-2-3-12-27(25)36)29(40-28)21-43-34-31(33(37)38-22-39-34)32(41-43)24-9-4-11-26(44)19-24/h2-5,7-9,11-13,19,22,44H,14-18,20-21H2,1H3,(H2,37,38,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM200639
(US9227977, Compound A)Show SMILES COCCN(CCOC)C(=O)CCCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)n(Cc3ccccc3Cl)c(=O)c12 Show InChI InChI=1S/C39H39ClN8O5/c1-52-20-18-46(19-21-53-2)33(50)17-5-3-4-10-26-12-9-16-31-34(26)39(51)47(23-28-11-6-7-15-30(28)40)32(44-31)24-48-38-35(37(41)42-25-43-38)36(45-48)27-13-8-14-29(49)22-27/h6-9,11-16,22,25,49H,3,5,17-21,23-24H2,1-2H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM200637
(US9227977, Compound (Ia))Show SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCOCCOCCO)c4c(=O)n3Cc3ccccc3C(F)(F)F)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C35H29F4N7O5/c36-24-15-23(16-25(48)17-24)31-30-32(40)41-20-42-33(30)46(44-31)19-28-43-27-9-3-6-21(7-4-11-50-13-14-51-12-10-47)29(27)34(49)45(28)18-22-5-1-2-8-26(22)35(37,38)39/h1-3,5-6,8-9,15-17,20,47-48H,10-14,18-19H2,(H2,40,41,42) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description As a means of assessing PI3K δ activation in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product of PI3K... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM200639
(US9227977, Compound A)Show SMILES COCCN(CCOC)C(=O)CCCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)n(Cc3ccccc3Cl)c(=O)c12 Show InChI InChI=1S/C39H39ClN8O5/c1-52-20-18-46(19-21-53-2)33(50)17-5-3-4-10-26-12-9-16-31-34(26)39(51)47(23-28-11-6-7-15-30(28)40)32(44-31)24-48-38-35(37(41)42-25-43-38)36(45-48)27-13-8-14-29(49)22-27/h6-9,11-16,22,25,49H,3,5,17-21,23-24H2,1-2H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM200638
(US9227977, Compound (I))Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)n(Cc3ccccc3C(F)(F)F)c(=O)c12 Show InChI InChI=1S/C36H31F4N7O5/c1-50-12-13-52-15-14-51-11-5-8-22-7-4-10-28-30(22)35(49)46(19-23-6-2-3-9-27(23)36(38,39)40)29(44-28)20-47-34-31(33(41)42-21-43-34)32(45-47)24-16-25(37)18-26(48)17-24/h2-4,6-7,9-10,16-18,21,48H,11-15,19-20H2,1H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM200640
(US9227977, Example 50)Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)n(Cc3ccccc3F)c(=O)c12 Show InChI InChI=1S/C35H32FN7O5/c1-46-15-16-48-18-17-47-14-6-10-23-8-5-13-28-30(23)35(45)42(20-25-7-2-3-12-27(25)36)29(40-28)21-43-34-31(33(37)38-22-39-34)32(41-43)24-9-4-11-26(44)19-24/h2-5,7-9,11-13,19,22,44H,14-18,20-21H2,1H3,(H2,37,38,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM200639
(US9227977, Compound A)Show SMILES COCCN(CCOC)C(=O)CCCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)n(Cc3ccccc3Cl)c(=O)c12 Show InChI InChI=1S/C39H39ClN8O5/c1-52-20-18-46(19-21-53-2)33(50)17-5-3-4-10-26-12-9-16-31-34(26)39(51)47(23-28-11-6-7-15-30(28)40)32(44-31)24-48-38-35(37(41)42-25-43-38)36(45-48)27-13-8-14-29(49)22-27/h6-9,11-16,22,25,49H,3,5,17-21,23-24H2,1-2H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 193 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM200637
(US9227977, Compound (Ia))Show SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCOCCOCCO)c4c(=O)n3Cc3ccccc3C(F)(F)F)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C35H29F4N7O5/c36-24-15-23(16-25(48)17-24)31-30-32(40)41-20-42-33(30)46(44-31)19-28-43-27-9-3-6-21(7-4-11-50-13-14-51-12-10-47)29(27)34(49)45(28)18-22-5-1-2-8-26(22)35(37,38)39/h1-3,5-6,8-9,15-17,20,47-48H,10-14,18-19H2,(H2,40,41,42) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 577 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description As a means of assessing the activation of PI3K γ in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product of... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM200640
(US9227977, Example 50)Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)n(Cc3ccccc3F)c(=O)c12 Show InChI InChI=1S/C35H32FN7O5/c1-46-15-16-48-18-17-47-14-6-10-23-8-5-13-28-30(23)35(45)42(20-25-7-2-3-12-27(25)36)29(40-28)21-43-34-31(33(37)38-22-39-34)32(41-43)24-9-4-11-26(44)19-24/h2-5,7-9,11-13,19,22,44H,14-18,20-21H2,1H3,(H2,37,38,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 653 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM200638
(US9227977, Compound (I))Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)n(Cc3ccccc3C(F)(F)F)c(=O)c12 Show InChI InChI=1S/C36H31F4N7O5/c1-50-12-13-52-15-14-51-11-5-8-22-7-4-10-28-30(22)35(49)46(19-23-6-2-3-9-27(23)36(38,39)40)29(44-28)20-47-34-31(33(41)42-21-43-34)32(45-47)24-16-25(37)18-26(48)17-24/h2-4,6-7,9-10,16-18,21,48H,11-15,19-20H2,1H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM200638
(US9227977, Compound (I))Show SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)n(Cc3ccccc3C(F)(F)F)c(=O)c12 Show InChI InChI=1S/C36H31F4N7O5/c1-50-12-13-52-15-14-51-11-5-8-22-7-4-10-28-30(22)35(49)46(19-23-6-2-3-9-27(23)36(38,39)40)29(44-28)20-47-34-31(33(41)42-21-43-34)32(45-47)24-16-25(37)18-26(48)17-24/h2-4,6-7,9-10,16-18,21,48H,11-15,19-20H2,1H3,(H2,41,42,43) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM200637
(US9227977, Compound (Ia))Show SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCOCCOCCO)c4c(=O)n3Cc3ccccc3C(F)(F)F)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C35H29F4N7O5/c36-24-15-23(16-25(48)17-24)31-30-32(40)41-20-42-33(30)46(44-31)19-28-43-27-9-3-6-21(7-4-11-50-13-14-51-12-10-47)29(27)34(49)45(28)18-22-5-1-2-8-26(22)35(37,38)39/h1-3,5-6,8-9,15-17,20,47-48H,10-14,18-19H2,(H2,40,41,42) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description As a means of assessing PI3K alpha or beta; activation in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product o... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM200637
(US9227977, Compound (Ia))Show SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCOCCOCCO)c4c(=O)n3Cc3ccccc3C(F)(F)F)nc(-c3cc(O)cc(F)c3)c12 Show InChI InChI=1S/C35H29F4N7O5/c36-24-15-23(16-25(48)17-24)31-30-32(40)41-20-42-33(30)46(44-31)19-28-43-27-9-3-6-21(7-4-11-50-13-14-51-12-10-47)29(27)34(49)45(28)18-22-5-1-2-8-26(22)35(37,38)39/h1-3,5-6,8-9,15-17,20,47-48H,10-14,18-19H2,(H2,40,41,42) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Ltd.
US Patent
| Assay Description As a means of assessing PI3K alpha or beta; activation in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product o... |
US Patent US9227977 (2016)
BindingDB Entry DOI: 10.7270/Q2BZ64WZ |
More data for this Ligand-Target Pair | |