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USPatent US9334271

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227484
PNG
(US9334271, 5)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cc(F)cc2[nH]ccc12 |r|
Show InChI InChI=1S/C23H24FN7O2/c1-13-11-32-7-5-30(13)22-19-21(28-23(29-22)31-6-8-33-12-14(31)2)27-20(26-19)17-9-15(24)10-18-16(17)3-4-25-18/h3-4,9-10,13-14H,5-8,11-12H2,1-2H3/b20-17-/t13-,14+/m1/s1
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n/an/a 21n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227510
PNG
(US9334271, 31)
Show SMILES COc1cc(-c2nc3c(nc(nc3[nH]2)N2CCOC[C@@H]2C)N2CCOC[C@H]2C)c2cc[nH]c2c1 |r|
Show InChI InChI=1S/C24H27N7O3/c1-14-12-33-8-6-30(14)23-20-22(28-24(29-23)31-7-9-34-13-15(31)2)27-21(26-20)18-10-16(32-3)11-19-17(18)4-5-25-19/h4-5,10-11,14-15H,6-9,12-13H2,1-3H3/b21-18-/t14-,15+/m1/s1
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n/an/a 28n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227494
PNG
(US9334271, 15)
Show SMILES CC[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r|
Show InChI InChI=1S/C24H27N7O2/c1-3-16-14-33-12-10-31(16)24-28-22-20(23(29-24)30-9-11-32-13-15(30)2)26-21(27-22)18-5-4-6-19-17(18)7-8-25-19/h4-8,15-16H,3,9-14H2,1-2H3/b21-18-/t15-,16-/m1/s1
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n/an/a 60n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227485
PNG
(US9334271, 6)
Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cc(CO)cc2[nH]ccc12 |r|
Show InChI InChI=1S/C24H27N7O3/c1-14-12-33-7-5-30(14)23-20-22(28-24(29-23)31-6-8-34-13-15(31)2)27-21(26-20)18-9-16(11-32)10-19-17(18)3-4-25-19/h3-4,9-10,14-15,32H,5-8,11-13H2,1-2H3/b21-18-/t14-,15-/m1/s1
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n/an/a 66n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227505
PNG
(US9334271, 26)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCO[C@@H](CO)C1 |r|
Show InChI InChI=1S/C23H25N7O3/c1-14-13-32-9-8-30(14)22-19-21(27-23(28-22)29-7-10-33-15(11-29)12-31)26-20(25-19)17-3-2-4-18-16(17)5-6-24-18/h2-6,14-15,31H,7-13H2,1H3/b20-17-/t14-,15-/m1/s1
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n/an/a 67n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227493
PNG
(US9334271, 14)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1C2CCC1CC(O)C2 |r,TLB:9:25:33.31.30:27.28,THB:32:31:25:27.28|
Show InChI InChI=1S/C25H27N7O2/c1-14-13-34-10-9-31(14)24-21-23(28-22(27-21)19-3-2-4-20-18(19)7-8-26-20)29-25(30-24)32-15-5-6-16(32)12-17(33)11-15/h2-4,7-8,14-17,33H,5-6,9-13H2,1H3/b22-19-/t14-,15?,16?,17?/m1/s1
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n/an/a 76n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227502
PNG
(US9334271, 23)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r|
Show InChI InChI=1S/C24H27N7O2/c1-14-13-32-10-9-31(14)23-20-22(28-24(29-23)30-11-15(2)33-16(3)12-30)27-21(26-20)18-5-4-6-19-17(18)7-8-25-19/h4-8,14-16H,9-13H2,1-3H3/b21-18-/t14-,15-,16+/m1/s1
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n/an/a 78n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227497
PNG
(US9334271, 18)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCN(CC1)C1COC1 |r|
Show InChI InChI=1S/C25H28N8O2/c1-16-13-34-12-11-33(16)24-21-23(28-22(27-21)19-3-2-4-20-18(19)5-6-26-20)29-25(30-24)32-9-7-31(8-10-32)17-14-35-15-17/h2-6,16-17H,7-15H2,1H3/b22-19-/t16-/m1/s1
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n/an/a 91n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227481
PNG
(US9334271, 2)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cc[nH]n1 |r|
Show InChI InChI=1S/C18H22N8O2/c1-11-9-27-7-5-25(11)17-14-16(21-15(20-14)13-3-4-19-24-13)22-18(23-17)26-6-8-28-10-12(26)2/h3-4,11-12H,5-10H2,1-2H3/b15-13-/t11-,12+/m1/s1
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n/an/a 104n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227496
PNG
(US9334271, 17)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CC2(C1)CCCOC2 |r|
Show InChI InChI=1S/C25H27N7O2/c1-16-12-33-11-9-32(16)23-20-22(28-21(27-20)18-4-2-5-19-17(18)6-8-26-19)29-24(30-23)31-13-25(14-31)7-3-10-34-15-25/h2,4-6,8,16H,3,7,9-15H2,1H3/b21-18-/t16-/m1/s1
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n/an/a 112n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227500
PNG
(US9334271, 21)
Show SMILES CC(C)[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r|
Show InChI InChI=1S/C25H29N7O2/c1-15(2)20-14-34-12-10-32(20)25-29-23-21(24(30-25)31-9-11-33-13-16(31)3)27-22(28-23)18-5-4-6-19-17(18)7-8-26-19/h4-8,15-16,20H,9-14H2,1-3H3/b22-18-/t16-,20+/m1/s1
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n/an/a 122n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227480
PNG
(US9334271, 1)
Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1ccccn1 |r|
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n/an/a 139n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227492
PNG
(US9334271, 13)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1C2CCC1CC(O)C2 |r,TLB:32:31:25:27.28,9:25:33.31.30:27.28|
Show InChI InChI=1S/C25H27N7O2/c1-14-13-34-10-9-31(14)24-21-23(28-22(27-21)19-3-2-4-20-18(19)7-8-26-20)29-25(30-24)32-15-5-6-16(32)12-17(33)11-15/h2-4,7-8,14-17,33H,5-6,9-13H2,1H3/b22-19-/t14-,15?,16?,17?/m1/s1
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n/an/a 143n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227482
PNG
(US9334271, 3)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCCOCC1 |r|
Show InChI InChI=1S/C23H25N7O2/c1-15-14-32-13-10-30(15)22-19-21(27-23(28-22)29-8-3-11-31-12-9-29)26-20(25-19)17-4-2-5-18-16(17)6-7-24-18/h2,4-7,15H,3,8-14H2,1H3/b20-17-/t15-/m1/s1
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n/an/a 164n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227486
PNG
(US9334271, 7)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1ccccn1 |r|
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n/an/a 184n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227491
PNG
(US9334271, 12)
Show SMILES CCC[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r|
Show InChI InChI=1S/C25H29N7O2/c1-3-5-17-15-34-13-11-32(17)25-29-23-21(24(30-25)31-10-12-33-14-16(31)2)27-22(28-23)19-6-4-7-20-18(19)8-9-26-20/h4,6-9,16-17H,3,5,10-15H2,1-2H3/b22-19-/t16-,17-/m1/s1
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Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227498
PNG
(US9334271, 19)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CC2COCC2C1 |r|
Show InChI InChI=1S/C24H25N7O2/c1-14-11-32-8-7-31(14)23-20-22(28-24(29-23)30-9-15-12-33-13-16(15)10-30)27-21(26-20)18-3-2-4-19-17(18)5-6-25-19/h2-6,14-16H,7-13H2,1H3/b21-18-/t14-,15?,16?/m1/s1
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n/an/a 296n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227495
PNG
(US9334271, 16)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCN(C)CC1 |r|
Show InChI InChI=1S/C23H26N8O/c1-15-14-32-13-12-31(15)22-19-21(27-23(28-22)30-10-8-29(2)9-11-30)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,15H,8-14H2,1-2H3/b20-17-/t15-/m1/s1
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n/an/a 308n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227489
PNG
(US9334271, 10)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cc[nH]n1 |r|
Show InChI InChI=1S/C18H22N8O2/c1-11-9-27-7-5-25(11)17-14-16(21-15(20-14)13-3-4-19-24-13)22-18(23-17)26-6-8-28-10-12(26)2/h3-4,11-12H,5-10H2,1-2H3/b15-13+/t11-,12-/m0/s1
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n/an/a 343n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227509
PNG
(US9334271, 30)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccc(cc1)-c1ncc[nH]1 |r|
Show InChI InChI=1S/C24H26N8O2/c1-15-13-33-11-9-31(15)23-19-22(29-24(30-23)32-10-12-34-14-16(32)2)28-21(27-19)18-5-3-17(4-6-18)20-25-7-8-26-20/h3-8,15-16H,9-14H2,1-2H3/t15-,16-/m0/s1
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n/an/a 364n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227503
PNG
(US9334271, 24)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC11CCOCC1 |r|
Show InChI InChI=1S/C25H27N7O2/c1-16-15-34-14-11-31(16)23-20-22(28-21(27-20)18-3-2-4-19-17(18)5-9-26-19)29-24(30-23)32-10-6-25(32)7-12-33-13-8-25/h2-5,9,16H,6-8,10-15H2,1H3/b21-18-/t16-/m1/s1
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n/an/a 369n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227504
PNG
(US9334271, 25)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCO[C@H](CO)C1 |r|
Show InChI InChI=1S/C23H25N7O3/c1-14-13-32-9-8-30(14)22-19-21(27-23(28-22)29-7-10-33-15(11-29)12-31)26-20(25-19)17-3-2-4-18-16(17)5-6-24-18/h2-6,14-15,31H,7-13H2,1H3/b20-17-/t14-,15+/m1/s1
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n/an/a 380n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227490
PNG
(US9334271, 11)
Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cc[nH]n1 |r|
Show InChI InChI=1S/C18H22N8O2/c1-11-9-27-7-5-25(11)17-14-16(21-15(20-14)13-3-4-19-24-13)22-18(23-17)26-6-8-28-10-12(26)2/h3-4,11-12H,5-10H2,1-2H3/b15-13-/t11-,12-/m1/s1
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n/an/a 385n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227499
PNG
(US9334271, 20)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC2COCC2C1 |r|
Show InChI InChI=1S/C25H27N7O2/c1-15-12-33-10-9-32(15)24-21-23(28-22(27-21)19-3-2-4-20-18(19)5-7-26-20)29-25(30-24)31-8-6-16-13-34-14-17(16)11-31/h2-5,7,15-17H,6,8-14H2,1H3/b22-19-/t15-,16?,17?/m1/s1
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n/an/a 484n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227511
PNG
(US9334271, 32)
Show SMILES COC(=O)c1cc(-c2nc3c(nc(nc3[nH]2)N2CCOC[C@H]2C)N2CCOC[C@H]2C)c2cc[nH]c2c1 |r|
Show InChI InChI=1S/C25H27N7O4/c1-14-12-35-8-6-31(14)23-20-22(29-25(30-23)32-7-9-36-13-15(32)2)28-21(27-20)18-10-16(24(33)34-3)11-19-17(18)4-5-26-19/h4-5,10-11,14-15H,6-9,12-13H2,1-3H3/b21-18-/t14-,15-/m1/s1
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n/an/a 533n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227507
PNG
(US9334271, 28)
Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1ccc(N)nc1 |r|
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n/an/a 754n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227488
PNG
(US9334271, 9)
Show SMILES C1CN(CCO1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1ccccn1
Show InChI InChI=1S/C18H21N7O2/c1-2-4-19-13(3-1)15-20-14-16(21-15)22-18(25-7-11-27-12-8-25)23-17(14)24-5-9-26-10-6-24/h1-4H,5-12H2,(H,20,21,22,23)
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n/an/a 860n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227487
PNG
(US9334271, 8)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccccn1 |r|
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n/an/a 1.03E+3n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227508
PNG
(US9334271, 29)
Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1cnc(N)nc1 |r|
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n/an/a 1.31E+3n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227501
PNG
(US9334271, 22)
Show SMILES C[C@@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC(CC1)C(F)(F)F |r|
Show InChI InChI=1S/C24H24F3N7O/c1-14-13-35-12-11-34(14)22-19-21(30-20(29-19)17-3-2-4-18-16(17)5-8-28-18)31-23(32-22)33-9-6-15(7-10-33)24(25,26)27/h2-5,8,14-15H,6-7,9-13H2,1H3/b20-17-/t14-/m1/s1
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n/an/a 1.51E+3n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227483
PNG
(US9334271, 4)
Show SMILES C[C@@H]1COCCN1c1nc(N2CCOC[C@H]2C)c2nc([nH]c2n1)-c1ccc(cc1)-c1ncc[nH]1 |r|
Show InChI InChI=1S/C24H26N8O2/c1-15-13-33-11-9-31(15)23-19-22(29-24(30-23)32-10-12-34-14-16(32)2)28-21(27-19)18-5-3-17(4-6-18)20-25-7-8-26-20/h3-8,15-16H,9-14H2,1-2H3/t15-,16-/m1/s1
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n/an/a 2.12E+3n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM227506
PNG
(US9334271, 27)
Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1ccc(N)nc1 |r|
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n/an/a 2.41E+3n/an/an/an/a7.525



Novarits AG

US Patent


Assay Description
1. 8-point serial dilutions of compounds (10 mM stock) are performed in 90% DMSO in a 384-well "masterplate" and 50 nL is transferred onto 384-well a...

US Patent US9334271 (2016)


BindingDB Entry DOI: 10.7270/Q2P55MCT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%