Found 110 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259335
(US9505745, 12 | US9790212, Example 12)Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259342
(US9505745, 19 | US9790212, Example 19)Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259355
(US9505745, 32 | US9790212, Example 32)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C |r,wU:3.2,wD:6.9,(5.55,-2.37,;4.46,-1.28,;2.98,-1.67,;2.58,-3.16,;3.67,-4.25,;3.27,-5.74,;1.78,-6.14,;.69,-5.05,;1.09,-3.56,;1.38,-7.62,;2.47,-8.71,;-.11,-8.02,;1.89,-.59,;.35,-.59,;-.13,.88,;1.12,1.78,;1.12,3.32,;2.45,4.09,;-.22,4.09,;-.22,5.63,;-1.55,6.4,;-1.55,7.94,;-.22,8.71,;-2.88,8.71,;-4.22,7.94,;-5.55,8.71,;-4.22,6.4,;-5.55,5.63,;-2.88,5.63,;-2.88,4.09,;2.36,.88,;3.7,1.65,)| Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20- | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259339
(US9505745, 16 | US9790212, Example 16)Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:25.29,wD:22.22,(10.2,-4.23,;9.43,-2.9,;7.89,-2.9,;7.12,-1.57,;8.21,-.48,;7.81,1.01,;8.9,2.1,;6.32,1.41,;5.23,.32,;3.75,.72,;5.63,-1.17,;4.54,-2.26,;4.94,-3.74,;3.85,-4.83,;2.37,-4.43,;4.25,-6.32,;3.35,-7.57,;4.25,-8.81,;5.72,-8.34,;7.05,-9.11,;8.38,-8.34,;9.72,-9.11,;7.05,-10.65,;5.72,-11.42,;5.72,-12.96,;7.05,-13.73,;8.38,-12.96,;8.38,-11.42,;7.05,-15.27,;8.38,-16.04,;5.72,-16.04,;5.72,-6.8,;7.05,-6.03,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259371
(US9505745, 48 | US9790212, Example 48)Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1 |(1.29,-4.65,;.52,-3.32,;-1.02,-3.32,;-1.79,-1.98,;-3.33,-1.98,;-3.81,-.52,;-2.56,.39,;-2.56,1.93,;-3.9,2.7,;-1.23,2.7,;-1.23,4.24,;.1,5.01,;.1,6.55,;-1.23,7.32,;1.44,7.32,;2.77,6.55,;4.1,7.32,;2.77,5.01,;1.44,4.24,;1.44,2.7,;-1.32,-.52,;.02,.25,;-1.79,-4.65,;-3.33,-4.65,;-4.1,-5.98,;-3.33,-7.32,;-1.79,-7.32,;-1.02,-5.98,)| Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259330
(US9505745, 7)Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259367
(US9505745, 44 | US9505745, 45 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-2.56,-3.32,;-3.33,-4.65,;-2.56,-5.98,;-1.02,-5.98,;-.25,-4.65,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259356
(US9505745, 33 | US9790212, Example 33)Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259359
(US9505745, 36 | US9790212, Example 36)Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.71,-2.37,;6.62,-1.28,;5.14,-1.67,;4.74,-3.16,;3.25,-3.56,;2.85,-5.05,;3.94,-6.14,;5.43,-5.74,;5.83,-4.25,;3.54,-7.62,;4.63,-8.71,;2.05,-8.02,;4.05,-.59,;2.51,-.59,;2.03,.88,;3.28,1.78,;3.28,3.32,;1.94,4.09,;4.61,4.09,;4.61,5.63,;5.94,6.4,;5.94,7.94,;4.61,8.71,;7.28,8.71,;8.61,7.94,;9.94,8.71,;8.61,6.4,;7.28,5.63,;7.28,4.09,;4.52,.88,;5.86,1.65,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259331
(US9505745, 8)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259341
(US9505745, 18 | US9790212, Example 18)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259369
(US9505745, 46 | US9505745, 47 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259358
(US9505745, 35)Show SMILES C\C=C(/[C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.6,wD:3.2,(7.69,-1.28,;6.6,-.19,;5.12,-.59,;4.72,-2.07,;3.23,-2.47,;2.83,-3.96,;3.92,-5.05,;3.52,-6.54,;5.41,-4.65,;5.81,-3.16,;4.03,.5,;2.49,.5,;2.01,1.97,;3.26,2.87,;3.26,4.41,;1.92,5.18,;4.59,5.18,;4.59,6.72,;5.93,7.49,;5.93,9.03,;4.59,9.8,;7.26,9.8,;8.59,9.03,;9.93,9.8,;8.59,7.49,;7.26,6.72,;7.26,5.18,;4.5,1.97,;5.84,2.74,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259341
(US9505745, 18 | US9790212, Example 18)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(7.97,-10.65,;6.88,-9.56,;5.4,-9.96,;5,-11.45,;3.51,-11.84,;3.11,-13.33,;4.2,-14.42,;5.69,-14.02,;6.09,-12.53,;3.8,-15.91,;4.89,-17,;2.31,-16.31,;4.31,-8.87,;2.77,-8.87,;2.29,-7.4,;3.54,-6.5,;3.54,-4.96,;2.2,-4.19,;4.87,-4.19,;4.87,-2.65,;6.2,-1.88,;7.54,-2.65,;7.54,-4.19,;8.87,-4.96,;8.87,-1.88,;8.87,-.34,;10.21,.43,;7.54,.43,;6.2,-.34,;4.87,.43,;4.78,-7.4,;6.27,-7.01,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259331
(US9505745, 8)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259327
(US9505745, 4 | US9790212, Example 4)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.26,-3.32,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;2.95,-4.65,;2.18,-5.98,;.64,-5.98,;-.13,-4.65,;.64,-3.32,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259376
(US9505745, 53 | US9790212, Example 53)Show SMILES CCN(C1CCOCC1)c1sc(Cl)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259387
(US9505745, 64 | US9790212, Example 64)Show SMILES CCN(C)[C@H]1CC[C@@H](CC1)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:4.3,wD:7.10,(4.62,-7.16,;3.14,-7.56,;2.05,-6.47,;.56,-6.87,;2.45,-4.98,;1.36,-3.89,;1.76,-2.41,;3.24,-2.01,;4.33,-3.1,;3.93,-4.58,;3.64,-.52,;5.13,-.12,;6.22,-1.21,;2.55,.57,;1.01,.57,;.54,2.03,;1.78,2.94,;1.78,4.48,;3.12,5.25,;.45,5.25,;-.88,4.48,;-2.22,5.25,;-3.55,4.48,;-3.55,2.94,;-4.89,5.25,;-4.89,6.79,;-6.22,7.56,;-3.55,7.56,;-2.22,6.79,;-.88,7.56,;3.03,2.03,;4.36,2.8,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259366
(US9505745, 43 | US9790212, Example 43)Show SMILES CCC([C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.6,wD:3.2,(1.29,-3.98,;.52,-2.65,;-1.02,-2.65,;-1.79,-3.98,;-3.33,-3.98,;-4.1,-5.32,;-3.33,-6.65,;-4.1,-7.98,;-1.79,-6.65,;-1.02,-5.32,;-1.79,-1.32,;-3.33,-1.32,;-3.81,.15,;-2.56,1.05,;-2.56,2.59,;-3.9,3.36,;-1.23,3.36,;-1.23,4.9,;.1,5.67,;.1,7.21,;-1.23,7.98,;1.44,7.98,;2.77,7.21,;4.1,7.98,;2.77,5.67,;1.44,4.9,;1.44,3.36,;-1.32,.15,;.02,.92,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259329
(US9505745, 6 | US9790212, Example 6)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259334
(US9505745, 11 | US9790212, Example 11)Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259329
(US9505745, 6 | US9790212, Example 6)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259351
(US9505745, 28 | US9790212, Example 28)Show SMILES CCC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259363
(US9505745, 40)Show SMILES CCC(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259334
(US9505745, 11 | US9790212, Example 11)Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259367
(US9505745, 44 | US9505745, 45 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-2.56,-3.32,;-3.33,-4.65,;-2.56,-5.98,;-1.02,-5.98,;-.25,-4.65,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259330
(US9505745, 7)Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(5.26,-.65,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;.64,-3.32,;-.13,-4.65,;.64,-5.98,;2.18,-5.98,;2.95,-4.65,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259342
(US9505745, 19 | US9790212, Example 19)Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259335
(US9505745, 12 | US9790212, Example 12)Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27) | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259390
(US9505745, 67 | US9790212, Example 67)Show SMILES CCN(C1CCNCC1F)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
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| PC cid
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| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259373
(US9505745, 50 | US9790212, Example 50)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(3.79,-1.39,;2.3,-.99,;1.21,-2.08,;1.61,-3.57,;3.09,-3.97,;3.49,-5.45,;2.4,-6.54,;.92,-6.14,;.52,-4.66,;2.8,-8.03,;1.71,-9.12,;4.29,-8.43,;-.28,-1.68,;-1.52,-2.59,;-2.77,-1.68,;-4.1,-2.45,;-2.29,-.22,;-3.06,1.12,;-4.6,1.12,;-2.29,2.45,;-3.06,3.78,;-2.29,5.12,;-.75,5.12,;.02,3.78,;.02,6.45,;-.75,7.79,;.02,9.12,;-2.29,7.79,;-3.06,6.45,;-4.6,6.45,;-.75,-.22,;.02,1.12,)| | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259364
(US9505745, 41 | US9790212, Example 41)Show SMILES CC[C@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r| | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259339
(US9505745, 16 | US9790212, Example 16)Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:25.29,wD:22.22,(10.2,-4.23,;9.43,-2.9,;7.89,-2.9,;7.12,-1.57,;8.21,-.48,;7.81,1.01,;8.9,2.1,;6.32,1.41,;5.23,.32,;3.75,.72,;5.63,-1.17,;4.54,-2.26,;4.94,-3.74,;3.85,-4.83,;2.37,-4.43,;4.25,-6.32,;3.35,-7.57,;4.25,-8.81,;5.72,-8.34,;7.05,-9.11,;8.38,-8.34,;9.72,-9.11,;7.05,-10.65,;5.72,-11.42,;5.72,-12.96,;7.05,-13.73,;8.38,-12.96,;8.38,-11.42,;7.05,-15.27,;8.38,-16.04,;5.72,-16.04,;5.72,-6.8,;7.05,-6.03,)| | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259327
(US9505745, 4 | US9790212, Example 4)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.26,-3.32,;4.49,-1.98,;2.95,-1.98,;2.18,-3.32,;2.95,-4.65,;2.18,-5.98,;.64,-5.98,;-.13,-4.65,;.64,-3.32,;-.13,-7.32,;-1.67,-7.32,;.64,-8.65,;2.18,-.65,;.64,-.65,;.16,.82,;1.41,1.72,;1.41,3.26,;2.74,4.03,;.08,4.03,;.08,5.57,;-1.26,6.34,;-1.26,7.88,;.08,8.65,;-2.59,8.65,;-3.93,7.88,;-5.26,8.65,;-3.93,6.34,;-2.59,5.57,;-2.59,4.03,;2.66,.82,;3.99,1.59,)| | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259374
(US9505745, 51 | US9790212, Example 51)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(4.36,-1.39,;2.87,-.99,;1.78,-2.08,;2.18,-3.57,;3.67,-3.97,;4.07,-5.45,;2.98,-6.54,;1.49,-6.14,;1.09,-4.66,;3.38,-8.03,;2.29,-9.12,;4.86,-8.43,;.29,-1.68,;-.95,-2.59,;-2.2,-1.68,;-3.53,-2.45,;-4.86,-3.22,;-1.72,-.22,;-2.49,1.12,;-4.03,1.12,;-1.72,2.45,;-2.49,3.78,;-1.72,5.12,;-.18,5.12,;.59,3.78,;.59,6.45,;-.18,7.79,;.59,9.12,;-1.72,7.79,;-2.49,6.45,;-4.03,6.45,;-.18,-.22,;.59,1.12,)| | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259398
(US9505745, 75 | US9790212, Example 75)Show SMILES CCN(C1CCOCC1)c1sc(-c2ccoc2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O4S/c1-5-28(19-7-10-31-11-8-19)25-17(4)21(22(33-25)18-6-9-32-14-18)24(30)26-13-20-15(2)12-16(3)27-23(20)29/h6,9,12,14,19H,5,7-8,10-11,13H2,1-4H3,(H,26,30)(H,27,29) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259350
(US9505745, 27 | US9790212, Example 27)Show SMILES CC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259400
(US9505745, 77 | US9790212, Example 77)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(-c2ccoc2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(3.64,-2.37,;2.55,-1.28,;1.06,-1.67,;.66,-3.16,;-.83,-3.56,;-1.22,-5.05,;-.14,-6.14,;1.35,-5.74,;1.75,-4.25,;-.53,-7.62,;-2.02,-8.02,;.55,-8.71,;-.03,-.59,;-1.57,-.59,;-2.04,.88,;-3.38,1.65,;-3.85,3.11,;-5.39,3.11,;-5.87,1.65,;-4.62,.74,;-.8,1.78,;-.8,3.32,;-2.13,4.09,;.54,4.09,;.54,5.63,;1.87,6.4,;1.87,7.94,;.54,8.71,;3.2,8.71,;4.54,7.94,;5.87,8.71,;4.54,6.4,;3.2,5.63,;3.2,4.09,;.45,.88,;1.78,1.65,)| | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259328
(US9505745, 5 | US9790212, Example 5)Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(7.61,-10.63,;6.84,-9.3,;5.3,-9.3,;4.53,-10.63,;2.99,-10.63,;2.22,-11.96,;2.99,-13.3,;4.53,-13.3,;5.3,-11.96,;2.22,-14.63,;.68,-14.63,;2.99,-15.96,;4.53,-7.96,;2.99,-7.96,;2.51,-6.5,;3.76,-5.59,;3.76,-4.05,;5.09,-3.28,;2.42,-3.28,;2.42,-1.74,;1.09,-.97,;1.09,.57,;2.42,1.34,;-.24,1.34,;-1.58,.57,;-2.91,1.34,;-1.58,-.97,;-.24,-1.74,;-.24,-3.28,;5,-6.5,;6.34,-5.73,)| | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259377
(US9505745, 54 | US9790212, Example 54)Show SMILES CCN(C1CCOCC1)c1sc(C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-15(4)19(16(5)29-22)21(27)23-12-18-13(2)11-14(3)24-20(18)26/h11,17H,6-10,12H2,1-5H3,(H,23,27)(H,24,26) | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259399
(US9505745, 76 | US9790212, Example 76)Show SMILES CCN(C1CCOCC1)c1sc(-c2ccco2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O4S/c1-5-28(18-8-11-31-12-9-18)25-17(4)21(22(33-25)20-7-6-10-32-20)24(30)26-14-19-15(2)13-16(3)27-23(19)29/h6-7,10,13,18H,5,8-9,11-12,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259355
(US9505745, 32 | US9790212, Example 32)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C |r,wU:3.2,wD:6.9,(5.55,-2.37,;4.46,-1.28,;2.98,-1.67,;2.58,-3.16,;3.67,-4.25,;3.27,-5.74,;1.78,-6.14,;.69,-5.05,;1.09,-3.56,;1.38,-7.62,;2.47,-8.71,;-.11,-8.02,;1.89,-.59,;.35,-.59,;-.13,.88,;1.12,1.78,;1.12,3.32,;2.45,4.09,;-.22,4.09,;-.22,5.63,;-1.55,6.4,;-1.55,7.94,;-.22,8.71,;-2.88,8.71,;-4.22,7.94,;-5.55,8.71,;-4.22,6.4,;-5.55,5.63,;-2.88,5.63,;-2.88,4.09,;2.36,.88,;3.7,1.65,)| Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20- | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259362
(US9505745, 39 | US9790212, Example 40)Show SMILES CCC(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259328
(US9505745, 5 | US9790212, Example 5)Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(7.61,-10.63,;6.84,-9.3,;5.3,-9.3,;4.53,-10.63,;2.99,-10.63,;2.22,-11.96,;2.99,-13.3,;4.53,-13.3,;5.3,-11.96,;2.22,-14.63,;.68,-14.63,;2.99,-15.96,;4.53,-7.96,;2.99,-7.96,;2.51,-6.5,;3.76,-5.59,;3.76,-4.05,;5.09,-3.28,;2.42,-3.28,;2.42,-1.74,;1.09,-.97,;1.09,.57,;2.42,1.34,;-.24,1.34,;-1.58,.57,;-2.91,1.34,;-1.58,-.97,;-.24,-1.74,;-.24,-3.28,;5,-6.5,;6.34,-5.73,)| | PDB
UniProtKB/SwissProt
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antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259351
(US9505745, 28 | US9790212, Example 28)Show SMILES CCC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259389
(US9505745, 66 | US9790212, Example 66)Show SMILES CCN(C1CCN(CC1)C(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-8-10-27(11-9-19)15(2)3)24-18(6)21(14-31-24)22(29)25-13-20-16(4)12-17(5)26-23(20)30/h12,14-15,19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30) | PDB
UniProtKB/SwissProt
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antibodypedia
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259325
(US9505745, 2 | US9790212, Example 2)Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25) | PDB
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antibodypedia
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antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259350
(US9505745, 27 | US9790212, Example 27)Show SMILES CC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
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antibodypedia
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259378
(US9505745, 55 | US9790212, Example 55)Show SMILES CCN(C1CCOCC1)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H28N4O3S/c1-5-26(16-6-8-29-9-7-16)22-15(4)19(18(11-23)30-22)21(28)24-12-17-13(2)10-14(3)25-20(17)27/h10,16H,5-9,12H2,1-4H3,(H,24,28)(H,25,27) | PDB
UniProtKB/SwissProt
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antibodypedia
antibodypedia
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259338
(US9505745, 15 | US9790212, Example 15)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29) | PDB
UniProtKB/SwissProt
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antibodypedia
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antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259391
(US9505745, 68 | US9790212, Example 68)Show SMILES Cc1c(csc1N1CCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
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antibodypedia
antibodypedia
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259348
(US9505745, 25 | US9790212, Example 25)Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259357
(US9505745, 34 | US9790212, Example 35)Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.06,-1.28,;3.97,-.19,;2.48,-.59,;2.09,-2.07,;3.17,-3.16,;2.78,-4.65,;1.29,-5.05,;.2,-3.96,;.6,-2.47,;.89,-6.54,;1.98,-7.62,;1.58,-9.11,;3.47,-7.23,;4.56,-8.32,;6.04,-7.92,;4.16,-9.8,;5.64,-9.4,;1.4,.5,;-.14,.5,;-.62,1.97,;.63,2.87,;.63,4.41,;1.96,5.18,;-.71,5.18,;-.71,6.72,;-2.04,7.49,;-2.04,9.03,;-.71,9.8,;-3.38,9.8,;-4.71,9.03,;-6.04,9.8,;-4.71,7.49,;-3.38,6.72,;-3.38,5.18,;1.87,1.97,;3.21,2.74,)| | PDB
UniProtKB/SwissProt
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antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259393
(US9505745, 70 | US9790212, Example 70)Show SMILES Cc1c(csc1-c1cccc2CNCCc12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C23H25N3O2S/c1-13-9-14(2)26-23(28)19(13)11-25-22(27)20-12-29-21(15(20)3)18-6-4-5-16-10-24-8-7-17(16)18/h4-6,9,12,24H,7-8,10-11H2,1-3H3,(H,25,27)(H,26,28) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259354
(US9505745, 31 | US9790212, Example 31)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259401
(US9505745, 78 | US9790212, Example 78)Show SMILES CCN(C1CCOCC1)c1sc(-c2cnn(C)c2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H33N5O3S/c1-6-30(19-7-9-33-10-8-19)25-17(4)21(22(34-25)18-12-27-29(5)14-18)24(32)26-13-20-15(2)11-16(3)28-23(20)31/h11-12,14,19H,6-10,13H2,1-5H3,(H,26,32)(H,28,31) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259344
(US9505745, 21)Show SMILES Cc1c(csc1C(O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
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antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259326
(US9505745, 3 | US9790212, Example 3)Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259396
(US9505745, 73 | US9790212, Example 73)Show SMILES CCC(CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259372
(US9505745, 49 | US9790212, Example 49)Show SMILES Cc1c(csc1C(=C)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C21H27N3O2S/c1-12-9-13(2)24-21(26)17(12)10-23-20(25)18-11-27-19(15(18)4)14(3)16-5-7-22-8-6-16/h9,11,16,22H,3,5-8,10H2,1-2,4H3,(H,23,25)(H,24,26) | PDB
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259361
(US9505745, 38 | US9790212, Example 38)Show SMILES CN(C)[C@H]1CC[C@@H](CC1)C(O)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,w:9.10,wU:3.2,wD:6.9,(4.68,-8.71,;3.59,-7.62,;2.1,-8.02,;3.99,-6.14,;2.9,-5.05,;3.3,-3.56,;4.78,-3.16,;5.87,-4.25,;5.47,-5.74,;5.18,-1.67,;6.67,-1.28,;4.09,-.59,;2.55,-.59,;2.08,.88,;3.32,1.78,;3.32,3.32,;1.99,4.09,;4.66,4.09,;4.66,5.63,;5.99,6.4,;5.99,7.94,;4.66,8.71,;7.33,8.71,;8.66,7.94,;9.99,8.71,;8.66,6.4,;7.33,5.63,;7.33,4.09,;4.57,.88,;5.9,1.65,)| | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259343
(US9505745, 20 | US9790212, Example 20)Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3 | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259325
(US9505745, 2 | US9790212, Example 2)Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259388
(US9505745, 65 | US9790212, Example 65)Show SMILES CCOC(=O)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C19H25N3O4S/c1-6-22(19(25)26-7-2)18-13(5)15(10-27-18)16(23)20-9-14-11(3)8-12(4)21-17(14)24/h8,10H,6-7,9H2,1-5H3,(H,20,23)(H,21,24) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259397
(US9505745, 74)Show SMILES C\C=C(/CCCN1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C27H40N4O2S/c1-7-21(9-8-12-31-13-10-22(11-14-31)30(5)6)25-20(4)24(17-34-25)26(32)28-16-23-18(2)15-19(3)29-27(23)33/h7,15,17,22H,8-14,16H2,1-6H3,(H,28,32)(H,29,33)/b21-7+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259326
(US9505745, 3 | US9790212, Example 3)Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259380
(US9505745, 57 | US9790212, Example 58)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259395
(US9505745, 72)Show SMILES C\C=C(/CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H36N4O2S/c1-6-20(8-7-9-29-12-10-28(5)11-13-29)23-19(4)22(16-32-23)24(30)26-15-21-17(2)14-18(3)27-25(21)31/h6,14,16H,7-13,15H2,1-5H3,(H,26,30)(H,27,31)/b20-6+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259347
(US9505745, 24 | US9790212, Example 24)Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259369
(US9505745, 46 | US9505745, 47 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259336
(US9505745, 13 | US9790212, Example 13)Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259375
(US9505745, 52 | US9790212, Example 52)Show SMILES CCN(CC)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C18H24BrN3O2S/c1-6-22(7-2)18-12(5)14(15(19)25-18)17(24)20-9-13-10(3)8-11(4)21-16(13)23/h8H,6-7,9H2,1-5H3,(H,20,24)(H,21,23) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259344
(US9505745, 21)Show SMILES Cc1c(csc1C(O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259365
(US9505745, 42 | US9790212, Example 42)Show SMILES CC[C@@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259340
(US9505745, 17 | US9790212, Example 17)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C |r,wU:6.9,wD:3.2,(9.44,-18.86,;8.11,-18.09,;6.78,-18.86,;6.78,-20.4,;5.44,-21.17,;5.44,-22.71,;6.78,-23.48,;8.11,-22.71,;8.11,-21.17,;6.78,-25.02,;8.11,-25.79,;5.44,-25.79,;5.44,-18.09,;3.98,-18.56,;3.07,-17.32,;3.98,-16.07,;3.58,-14.58,;2.09,-14.19,;4.67,-13.49,;4.27,-12.01,;5.36,-10.92,;6.85,-11.32,;7.24,-12.8,;7.94,-10.23,;7.54,-8.74,;6.05,-8.34,;4.96,-9.43,;3.47,-9.03,;8.63,-7.65,;10.11,-8.05,;8.23,-6.16,;9.71,-6.56,;5.44,-16.55,;6.78,-15.78,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259382
(US9505745, 59 | US9790212, Example 59)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C31H46N4O5S/c1-8-35(23-11-15-39-16-12-23)29-21(4)25(28(37)32-18-24-19(2)17-20(3)33-27(24)36)26(41-29)22-9-13-34(14-10-22)30(38)40-31(5,6)7/h17,22-23H,8-16,18H2,1-7H3,(H,32,37)(H,33,36) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259352
(US9505745, 29 | US9790212, Example 29)Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259345
(US9505745, 22 | US9790212, Example 22)Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259392
(US9505745, 69 | US9790212, Example 69)Show SMILES Cc1c(csc1N1CCCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259379
(US9505745, 56 | US9790212, Example 56)Show SMILES CCN(C1CCOCC1)c1sc(N2CCN(C)CC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H39N5O3S/c1-6-31(20-7-13-34-14-8-20)25-19(4)22(26(35-25)30-11-9-29(5)10-12-30)24(33)27-16-21-17(2)15-18(3)28-23(21)32/h15,20H,6-14,16H2,1-5H3,(H,27,33)(H,28,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259386
(US9505745, 63 | US9790212, Example 63)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C27H40N4O5S2/c1-6-31(21-9-13-36-14-10-21)27-19(4)23(24(37-27)20-7-11-30(12-8-20)38(5,34)35)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h15,20-21H,6-14,16H2,1-5H3,(H,28,33)(H,29,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259384
(US9505745, 61 | US9790212, Example 61)Show SMILES CCN(C1CCOCC1)c1sc(c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CCN(C)CC1 |t:31| Show InChI InChI=1S/C27H38N4O3S/c1-6-31(21-9-13-34-14-10-21)27-19(4)23(24(35-27)20-7-11-30(5)12-8-20)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h7,15,21H,6,8-14,16H2,1-5H3,(H,28,33)(H,29,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259346
(US9505745, 23 | US9790212, Example 23)Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259360
(US9505745, 37 | US9790212, Example 37)Show SMILES Cc1c(csc1C(O)[C@H]1CC[C@H](N)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O |r,w:6.7,wU:11.12,wD:8.8,(-.09,1.1,;-1.42,.33,;-2.67,1.24,;-3.91,.33,;-3.44,-1.13,;-1.9,-1.13,;-.81,-2.22,;.68,-1.82,;-1.21,-3.71,;-2.69,-4.11,;-3.09,-5.59,;-2,-6.68,;-2.4,-8.17,;-.52,-6.28,;-.12,-4.8,;-2.67,2.78,;-4,3.55,;-1.33,3.55,;-1.33,5.09,;,5.86,;,7.4,;-1.33,8.17,;1.33,8.17,;2.67,7.4,;4,8.17,;2.67,5.86,;1.33,5.09,;1.33,3.55,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259385
(US9505745, 62 | US9790212, Example 62)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259338
(US9505745, 15 | US9790212, Example 15)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259348
(US9505745, 25 | US9790212, Example 25)Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259349
(US9505745, 26 | US9790212, Example 26)Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259340
(US9505745, 17 | US9790212, Example 17)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C |r,wU:6.9,wD:3.2,(9.44,-18.86,;8.11,-18.09,;6.78,-18.86,;6.78,-20.4,;5.44,-21.17,;5.44,-22.71,;6.78,-23.48,;8.11,-22.71,;8.11,-21.17,;6.78,-25.02,;8.11,-25.79,;5.44,-25.79,;5.44,-18.09,;3.98,-18.56,;3.07,-17.32,;3.98,-16.07,;3.58,-14.58,;2.09,-14.19,;4.67,-13.49,;4.27,-12.01,;5.36,-10.92,;6.85,-11.32,;7.24,-12.8,;7.94,-10.23,;7.54,-8.74,;6.05,-8.34,;4.96,-9.43,;3.47,-9.03,;8.63,-7.65,;10.11,-8.05,;8.23,-6.16,;9.71,-6.56,;5.44,-16.55,;6.78,-15.78,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259337
(US9505745, 14 | US9790212, Example 14)Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259383
(US9505745, 60 | US9790212, Example 60)Show SMILES CCN(C1CCOCC1)c1sc(C2CCNCC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H38N4O3S/c1-5-30(20-8-12-33-13-9-20)26-18(4)22(23(34-26)19-6-10-27-11-7-19)25(32)28-15-21-16(2)14-17(3)29-24(21)31/h14,19-20,27H,5-13,15H2,1-4H3,(H,28,32)(H,29,31) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259354
(US9505745, 31 | US9790212, Example 31)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259381
(US9505745, 58)Show SMILES CCN(C1CCOCC1)c1sc(C2CCNC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259394
(US9505745, 71)Show SMILES C\C=C(/CCN1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C23H31N3O3S/c1-5-18(6-7-26-8-10-29-11-9-26)21-17(4)20(14-30-21)22(27)24-13-19-15(2)12-16(3)25-23(19)28/h5,12,14H,6-11,13H2,1-4H3,(H,24,27)(H,25,28)/b18-5+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259343
(US9505745, 20 | US9790212, Example 20)Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3 | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259337
(US9505745, 14 | US9790212, Example 14)Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259336
(US9505745, 13 | US9790212, Example 13)Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259352
(US9505745, 29 | US9790212, Example 29)Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259324
(US9505745, 1 | US9790212, Example 1)Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259346
(US9505745, 23 | US9790212, Example 23)Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259347
(US9505745, 24 | US9790212, Example 24)Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259349
(US9505745, 26 | US9790212, Example 26)Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259345
(US9505745, 22 | US9790212, Example 22)Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259333
(US9505745, 10 | US9790212, Example 10)Show SMILES Cc1c(cnn1CC1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C19H26N4O3/c1-12-8-13(2)22-19(25)16(12)9-20-18(24)17-10-21-23(14(17)3)11-15-4-6-26-7-5-15/h8,10,15H,4-7,9,11H2,1-3H3,(H,20,24)(H,22,25) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259332
(US9505745, 9 | US9790212, Example 9)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C19H20N4O2/c1-12-9-13(2)22-19(25)16(12)10-20-18(24)17-11-21-23(14(17)3)15-7-5-4-6-8-15/h4-9,11H,10H2,1-3H3,(H,20,24)(H,22,25) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259324
(US9505745, 1 | US9790212, Example 1)Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259353
(US9505745, 30 | US9790212, Example 30)Show SMILES CCN(C1CCOCC1)c1ccc(s1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C20H27N3O3S/c1-4-23(15-7-9-26-10-8-15)18-6-5-17(27-18)20(25)21-12-16-13(2)11-14(3)22-19(16)24/h5-6,11,15H,4,7-10,12H2,1-3H3,(H,21,25)(H,22,24) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259332
(US9505745, 9 | US9790212, Example 9)Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C19H20N4O2/c1-12-9-13(2)22-19(25)16(12)10-20-18(24)17-11-21-23(14(17)3)15-7-5-4-6-8-15/h4-9,11H,10H2,1-3H3,(H,20,24)(H,22,25) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259333
(US9505745, 10 | US9790212, Example 10)Show SMILES Cc1c(cnn1CC1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C19H26N4O3/c1-12-8-13(2)22-19(25)16(12)9-20-18(24)17-10-21-23(14(17)3)11-15-4-6-26-7-5-15/h8,10,15H,4-7,9,11H2,1-3H3,(H,20,24)(H,22,25) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259353
(US9505745, 30 | US9790212, Example 30)Show SMILES CCN(C1CCOCC1)c1ccc(s1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C20H27N3O3S/c1-4-23(15-7-9-26-10-8-15)18-6-5-17(27-18)20(25)21-12-16-13(2)11-14(3)22-19(16)24/h5-6,11,15H,4,7-10,12H2,1-3H3,(H,21,25)(H,22,24) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
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