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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | CREB-binding protein [1081-1197] | ||
| Ligand | BDBM511390 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | CBP AlphaScreen Assay | ||
| IC50 | 2.00±n/a nM | ||
| Citation |  Le, K; Soth, MJ; Jones, P; Cross, JB; Carroll, CL; McAfoos, TJ; Mandal, PK Imidazopiperazine inhibitors of transcription activating proteins US Patent US11058688 Publication Date 7/13/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| CREB-binding protein [1081-1197] | |||
| Name: | CREB-binding protein [1081-1197] | ||
| Synonyms: | CBP | CBP_HUMAN | CREB-binding protein (CBP)(1081-1197) | CREBBP | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13987.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q92793[1081-1197] | ||
| Residue: | 117 | ||
| Sequence: |
| ||
| BDBM511390 | |||
| n/a | |||
| Name | BDBM511390 | ||
| Synonyms: | 1-(7-fluoro-3-(2- methylthiazol-5- yl)isoquinolin-8-yl)-N- methyl-3-(tetrahydro-2H- pyran-4-yl)-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide | US11058688, Example 89 | US11058688, Example 95 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27FN6O2S | ||
| Mol. Mass. | 506.595 | ||
| SMILES | CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1c(F)ccc2cc(ncc12)-c1cnc(C)s1 |(-5.55,.26,;-4.22,1.03,;-2.89,.26,;-2.89,-1.28,;-1.55,1.03,;-1.55,2.57,;-.22,3.34,;1.11,2.57,;1.11,1.03,;-.22,.26,;2.58,.55,;3.48,1.8,;2.58,3.05,;2.98,4.53,;4.47,4.93,;4.86,6.42,;3.77,7.51,;2.29,7.11,;1.89,5.62,;2.98,-.93,;4.47,-1.33,;5.55,-.24,;4.86,-2.82,;3.77,-3.91,;2.29,-3.51,;1.2,-4.6,;-.29,-4.2,;-.69,-2.71,;.4,-1.62,;1.89,-2.02,;-1.38,-5.29,;-1.14,-6.81,;-2.51,-7.51,;-3.6,-6.42,;-5.09,-6.82,;-2.9,-5.05,)| | ||
| Structure | 
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