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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | CREB-binding protein [1081-1197] | ||
| Ligand | BDBM511394 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | CBP AlphaScreen Assay | ||
| IC50 | 2.00±n/a nM | ||
| Citation |  Le, K; Soth, MJ; Jones, P; Cross, JB; Carroll, CL; McAfoos, TJ; Mandal, PK Imidazopiperazine inhibitors of transcription activating proteins US Patent US11058688 Publication Date 7/13/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| CREB-binding protein [1081-1197] | |||
| Name: | CREB-binding protein [1081-1197] | ||
| Synonyms: | CBP | CBP_HUMAN | CREB-binding protein (CBP)(1081-1197) | CREBBP | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13987.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q92793[1081-1197] | ||
| Residue: | 117 | ||
| Sequence: |
| ||
| BDBM511394 | |||
| n/a | |||
| Name | BDBM511394 | ||
| Synonyms: | 3-(4,4- difluorocyclohexyl)-1-(7- fluoro-3-(2-methylthiazol- 5-yl)isoquinolin-8-yl)-N- methyl-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide | US11058688, Example 93 | US11058688, Example 97 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H27F3N6OS | ||
| Mol. Mass. | 540.603 | ||
| SMILES | CNC(=O)N1CCn2c(C1)c(nc2C1CCC(F)(F)CC1)-c1c(F)ccc2cc(ncc12)-c1cnc(C)s1 |(-5.55,-.48,;-4.22,.29,;-2.89,-.48,;-2.89,-2.02,;-1.55,.29,;-1.55,1.83,;-.22,2.6,;1.11,1.83,;1.11,.29,;-.22,-.48,;2.58,-.19,;3.48,1.06,;2.58,2.3,;2.98,3.79,;4.47,4.19,;4.86,5.68,;3.77,6.77,;4.86,7.85,;3.38,8.25,;2.29,6.37,;1.89,4.88,;2.98,-1.68,;4.47,-2.08,;5.55,-.99,;4.86,-3.56,;3.77,-4.65,;2.29,-4.25,;1.2,-5.34,;-.29,-4.94,;-.69,-3.46,;.4,-2.37,;1.89,-2.77,;-1.38,-6.03,;-1.14,-7.55,;-2.51,-8.25,;-3.6,-7.16,;-5.09,-7.56,;-2.9,-5.79,)| | ||
| Structure | 
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