Reaction Details |
| Report a problem with these data |
Target | Diacylglycerol O-acyltransferase 2 |
---|
Ligand | BDBM517333 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzymatic Activity Assay |
---|
IC50 | 4.50±n/a nM |
---|
Citation | Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US11104690 Publication Date 8/31/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Diacylglycerol O-acyltransferase 2 |
---|
Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
|
|
BDBM517333 |
---|
n/a |
---|
Name | BDBM517333 |
Synonyms: | 3-(5-cyano-2-fluorophenyl)- 1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-1H-indazole-6- carboxamide (enantiomer A) | US11104690, Example 151-A |
Type | Small organic molecule |
Emp. Form. | C26H20F2N4O3S |
Mol. Mass. | 506.524 |
SMILES | C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cc3)c2c1)-c1cc(ccc1F)C#N |r| |
Structure |
|