| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM517367 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| IC50 | 28.0±n/a nM |
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| Citation |  Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US11104690 Publication Date 8/31/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM517367 |
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| n/a |
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| Name | BDBM517367 |
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| Synonyms: | 1-(4-fluorophenyl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen- 3-yl)-3-[3-(5-methyl-1,3,4- oxadiazol-2-yl)phenyl]-1H- indazole-6-carboxamide (racemic) | US11104690, Example 164 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24FN5O4S |
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| Mol. Mass. | 545.585 |
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| SMILES | Cc1nnc(o1)-c1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1(C)CCS(=O)(=O)C1 |
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| Structure | 
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