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TargetBromodomain-containing protein 4 [49-170]
LigandBDBM205429
Substrate/Competitorn/a
Meas. Tech.Plate-Based Time-Resolved Fluorescence Energy Transfer (TR-FRET) Assays
IC50 92.0±n/a nM
Citation Zhou, J; Brasier, AR; Tian, B; Liu, Z; Chen, H; Rytting, E Inhibitors of bromodomain-containing protein 4 (BRD4) US Patent US11117865 Publication Date 9/14/2021
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 [49-170]
Name:Bromodomain-containing protein 4 [49-170]
Synonyms:BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:Enzyme Catalytic Domain
Mol. Mass.:14593.14
Organism:Homo sapiens (Human)
Description:aa 49-170 (BRD4-BD1)
Residue:122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMG
TIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
TE
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  Blast E-value cutoff:
BDBM205429
n/a
NameBDBM205429
Synonyms: (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10925881, Name (R)-JQ1 | US11028051, Cmpd (+)-JQ1 | US11117865, Compound JQ1 | US11306105, Compound JQ1 | US11406645, Compound JQ1 | US11542273, Example (+)-JQ1 | US11890288, Compound (+)-JQ1 | US9320741, (R)-JQ1
TypeSmall organic molecule
Emp. Form.C23H25ClN4O2S
Mol. Mass.456.988
SMILESCc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14|
Structure
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