| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [342-460] |
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| Ligand | BDBM518799 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Plate-Based Time-Resolved Fluorescence Energy Transfer (TR-FRET) Assays |
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| IC50 | 1170±n/a nM |
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| Citation |  Zhou, J; Brasier, AR; Tian, B; Liu, Z; Chen, H; Rytting, E Inhibitors of bromodomain-containing protein 4 (BRD4) US Patent US11117865 Publication Date 9/14/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [342-460] |
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| Name: | Bromodomain-containing protein 4 [342-460] |
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| Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 13783.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | a.a. 342-460 (BRD4-BD2) |
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| Residue: | 119 |
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| Sequence: | PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMS
TIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
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| BDBM518799 |
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| n/a |
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| Name | BDBM518799 |
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| Synonyms: | US11117865, Compound ZL0591 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29F3N4O4S |
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| Mol. Mass. | 526.572 |
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| SMILES | OC1CCN(C[C@@H]2CCCN2S(=O)(=O)c2ccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)cc2)CC1 |r| |
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| Structure | 
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