Reaction Details | |||
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Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | ||
Ligand | BDBM529911 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Chelation-Enhanced Fluorescence (CHEF) Assay | ||
Ki | 13.0±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | |||
Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | ||
Synonyms: | CDK4/CycD | CDK4/CycD1 | CDK4/Cyclin D1 | CDK4/D1 | Cyclin-Dependent Kinase 4 (CDK4) | Cyclin-dependent kinase 4 | Cyclin-dependent kinase 4/G1/S-specific cyclin D1 | Cyclin-dependent kinase 4/cyclin D1 | ||
Type: | Protein Complex | ||
Mol. Mass.: | n/a | ||
Description: | CDK4/D1 complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 4 | ||
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 33731.96 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11802 | ||
Residue: | 303 | ||
Sequence: |
| ||
Component 2 | |||
Name: | G1/S-specific cyclin-D1 | ||
Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 33717.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 295 | ||
Sequence: |
| ||
BDBM529911 | |||
n/a | |||
Name | BDBM529911 | ||
Synonyms: | US11203594, Example 21 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H24N4O5 | ||
Mol. Mass. | 388.4177 | ||
SMILES | CC(=O)c1c(C)c2cnc(N[C@@H]3CCOC[C@H]3O)nc2n([C@H]2C[C@H](O)C2)c1=O |wU:11.10,23.25,wD:16.17,21.22,(-4,-2.31,;-2.67,-3.08,;-2.67,-4.62,;-1.33,-2.31,;,-3.08,;,-4.62,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;4,-.77,;5.33,,;6.67,-.77,;6.67,-2.31,;8,-3.08,;9.34,-2.31,;9.34,-.77,;8,,;8,1.54,;2.67,,;1.33,-.77,;;,1.54,;1.09,2.63,;,3.72,;,5.26,;-1.09,2.63,;-1.33,-.77,;-2.67,,)| | ||
Structure | ![]() |