Reaction Details | |||
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Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 | ||
Ligand | BDBM529914 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Chelation-Enhanced Fluorescence (CHEF) Assay | ||
Ki | 24.0±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 | |||
Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 | ||
Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 6 | ||
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 36937.42 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00534 | ||
Residue: | 326 | ||
Sequence: |
| ||
Component 2 | |||
Name: | G1/S-specific cyclin-D3 | ||
Synonyms: | CCND3 | CCND3_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 32521.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30281 | ||
Residue: | 292 | ||
Sequence: |
| ||
BDBM529914 | |||
n/a | |||
Name | BDBM529914 | ||
Synonyms: | US11203594, Example 24 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H29N5O4 | ||
Mol. Mass. | 415.4861 | ||
SMILES | CC(=O)c1c(C)c2cnc(N[C@@H]3CCOC[C@H]3O)nc2n([C@H]2CC[C@H](N)CC2)c1=O |wU:11.10,24.26,wD:16.17,21.22,(-4,-2.31,;-2.67,-3.08,;-2.67,-4.62,;-1.33,-2.31,;,-3.08,;,-4.62,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;4,-.77,;5.33,,;6.67,-.77,;6.67,-2.31,;8,-3.08,;9.34,-2.31,;9.34,-.77,;8,,;8,1.54,;2.67,,;1.33,-.77,;;,1.54,;1.33,2.31,;1.33,3.85,;,4.62,;,6.16,;-1.33,3.85,;-1.33,2.31,;-1.33,-.77,;-2.67,,)| | ||
Structure | ![]() |