Reaction Details |
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Target | Interleukin-1 beta |
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Ligand | BDBM531324 |
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Substrate/Competitor | n/a |
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Meas. Tech. | IL-1 Secretion Assa |
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IC50 | 18.3±n/a nM |
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Citation | Farady, C; Gommermann, N; Janser, P; Mackay, A; Mattes, H; Smith, N; Solovay, CF; Stiefl, NJ; Vangrevelinghe, E; Velcicky, J; von Matt, A NLRP3 inflammasome inhibitors US Patent US11208399 Publication Date 12/28/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 beta |
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Name: | Interleukin-1 beta |
Synonyms: | IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta |
Type: | Cytokine |
Mol. Mass.: | 30734.47 |
Organism: | Homo sapiens (Human) |
Description: | P01584 |
Residue: | 269 |
Sequence: | MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
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BDBM531324 |
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n/a |
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Name | BDBM531324 |
Synonyms: | US11208399, Example 75 |
Type | Small organic molecule |
Emp. Form. | C17H18F4N4O |
Mol. Mass. | 370.3446 |
SMILES | Cc1cc(cc(O)c1-c1ccc(NC[C@@H]2C[C@H](F)CN2)nn1)C(F)(F)F |r| |
Structure |
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