Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531296 (US11208399, Example 53) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531223 ((R)-2-(4-Methyl-6-((1-methylpiperidin-3-yl)amino)p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531253 (US11208399, Example 12) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531331 (US11208399, Example 82) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531319 (US11208399, Example 71) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531289 (US11208399, Example 48) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531332 (US11208399, Example 83a) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531220 ((R)-2-(6-((1-Ethylpiperidin-3-yl)amino)pyridazin-3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531288 (US11208399, Example 47) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531230 (US11208399, Example 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531254 (US11208399, Example 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531337 (3-Methyl-2-(6-(((1R,2R,5R)-8-methyl-8-azabicyclo[3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531252 (US11208399, Example 11) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531291 (US11208399, Example 49) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531354 (2-(6-(((3S, 5S)-5-Fluoro-1-methylpiperidin-3-yl)am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531339 (2-(6-(((1S,2S,5S)-8-(2-Hydroxyethyl)-8-azabicyclo[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531232 (US11208399, Example 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531364 ((R)-2-(6-((1-Ethylpiperidin-3-yl)amino)-5-methylpy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50320214 (3-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of SRC | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531292 (US11208399, Example 50) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531323 (US11208399, Example 74) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531293 (US11208399, Example 51) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531282 (US11208399, Example 41) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531224 ((R)-3-Methyl-2-(5-methyl-6-((1-methylpiperidin-3-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531279 (US11208399, Example 39) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531286 (US11208399, Example 45) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531350 (2-(6-(((R)-1-((S)-2-Hydroxypropyl)piperidin-3-yl)a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531318 (US11208399, Example 70) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531351 (2-(6-(((R)-1-((R)-2-Hydroxypropyl)piperidin-3-yl)a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320225 (CHEMBL1085316 | N-(4-(7-amino-3-(3-(4-methylpipera...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320205 (CHEMBL1083001 | N-(4-(7-amino-3-(4-(4-methylpipera...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531329 (US11208399, Example 80) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320209 (1-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531310 (US11208399, Example 64) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531363 ((R)-3-Methyl-2-(5-methyl-6-(piperidin-3-ylamino)py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320224 (1-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531340 (2-(6-(((3R,6R)-6-(Hydroxymethyl)-1-methylpiperidin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531352 (2-(6-(((3S,5S)-5-Fluoropiperidin-3-yl)amino)pyrida...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531280 (US11208399, Example 40) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320218 (CHEMBL1082404 | isobutyl4-(7-amino-3-(3-(4-(2-amin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assay | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320216 (CHEMBL1083644 | isobutyl4-(7-amino-3-(3-(piperazin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assay | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531311 (US11208399, Example 65) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531360 ((3S,5R)-5-((6-(2-Hydroxy-6-methyl-4-(trifluorometh...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320223 (1-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320204 (3-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM50524338 (CHEMBL4468000) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human CFD expressed in Escherichia coli incubated up to 2 hrs by TR-FRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01020 BindingDB Entry DOI: 10.7270/Q20K2D8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50320214 (3-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assay | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase HCK (Homo sapiens (Human)) | BDBM50320214 (3-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute of Biomedical Research Curated by ChEMBL | Assay Description Inhibition of HCK | Bioorg Med Chem Lett 20: 3628-31 (2010) Article DOI: 10.1016/j.bmcl.2010.04.112 BindingDB Entry DOI: 10.7270/Q2XP754D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531302 (US11208399, Example 56) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-1 beta (Homo sapiens (Human)) | BDBM531221 (2-(6-(((cis)-3-Hydroxy-3-methylcyclobutyl)amino)py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu... | Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5 | |||||||||||
More data for this Ligand-Target Pair |
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