| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 beta |
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| Ligand | BDBM531252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IL-1 Secretion Assa |
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| IC50 | 1.30±n/a nM |
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| Citation |  Farady, C; Gommermann, N; Janser, P; Mackay, A; Mattes, H; Smith, N; Solovay, CF; Stiefl, NJ; Vangrevelinghe, E; Velcicky, J; von Matt, A NLRP3 inflammasome inhibitors US Patent US11208399 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Interleukin-1 beta |
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| Name: | Interleukin-1 beta |
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| Synonyms: | IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta |
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| Type: | Cytokine |
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| Mol. Mass.: | 30734.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01584 |
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| Residue: | 269 |
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| Sequence: | MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
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|
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| BDBM531252 |
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| n/a |
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| Name | BDBM531252 |
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| Synonyms: | US11208399, Example 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22F3N5O |
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| Mol. Mass. | 405.4168 |
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| SMILES | CCN1CCC[C@H](C1)Nc1nnc(cc1C#N)-c1c(C)cc(cc1O)C(F)(F)F |r| |
|---|
| Structure | 
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