Ki Summary

Reaction Details

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Target

Induced myeloid leukemia cell differentiation protein Mcl-1

Ligand

BDBM429155

Substrate/Competitor

n/a

Meas. Tech.

Bak Peptide Binding Assay

<50.0±n/a nM

Citation

Lee, T; Bian, Z; Belmar, J; Christov, PP; Pelz, NF; Shaw, S; Kim, K; Tarr, JC; Olejniczak, ET; Zhao, B; Fesik, SW Substituted indole Mcl-1 inhibitors US Patent US11208415 Publication Date 12/28/2021

More Info.:

Get all data from this article, Assay Method

Induced myeloid leukemia cell differentiation protein Mcl-1

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1

Synonyms:

Type:

Membrane; Single-pass membrane protein

Mol. Mass.:

37332.87

Organism:

Homo sapiens (Human)

Description:

Q07820

Residue:

350

Sequence:

MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

BDBM429155

n/a

Name

BDBM429155

Synonyms:

US10533010, Example I-270 | US11208415, Example I-270

Type

Small organic molecule

Emp. Form.

C38H44ClN5O6

Mol. Mass.

702.239

SMILES

CC[C@H](C)[C@H](NC(=O)c1ccc(CNC(=O)c2[nH]c3c(cccc3c2CCCOc2cc(C)c(Cl)c(C)c2)-c2c(C)nn(C)c2C)o1)C(O)=O |r,wU:4.4,2.2,(-13.88,5.68,;-12.64,6.59,;-11.23,5.96,;-11.07,4.43,;-9.98,6.87,;-8.58,6.24,;-7.33,7.15,;-7.49,8.68,;-5.92,6.52,;-4.59,7.29,;-3.45,6.26,;-4.07,4.85,;-3.3,3.52,;-1.76,3.52,;-.99,2.19,;-1.76,.85,;.55,2.19,;1.45,3.43,;2.92,2.96,;4.25,3.73,;5.59,2.96,;5.59,1.42,;4.25,.65,;2.92,1.42,;1.45,.94,;.98,-.52,;2.01,-1.67,;1.53,-3.13,;2.56,-4.28,;2.09,-5.74,;.58,-6.06,;.1,-7.53,;-1.4,-7.85,;1.13,-8.67,;.66,-10.14,;2.64,-8.35,;3.67,-9.5,;3.12,-6.89,;4.25,5.27,;3.01,6.17,;1.54,5.7,;3.48,7.64,;5.02,7.64,;5.93,8.88,;5.5,6.17,;6.96,5.7,;-5.6,5.01,;-10.14,8.4,;-8.9,9.31,;-11.55,9.03,)|

Structure