Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase JAK1 [866-1154] |
---|
Ligand | BDBM264180 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
IC50 | 43.0±n/a nM |
---|
Citation | Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US11247983 Publication Date 2/15/2022 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase JAK1 [866-1154] |
---|
Name: | Tyrosine-protein kinase JAK1 [866-1154] |
Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
Type: | Protein |
Mol. Mass.: | 33185.74 |
Organism: | Homo sapiens (Human) |
Description: | P23458[866-1154] |
Residue: | 289 |
Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
|
|
|
BDBM264180 |
---|
n/a |
---|
Name | BDBM264180 |
Synonyms: | (2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H-indol- 7-yl)propanamide | US10167276, Example 4 | US10654835, Example 4 | US11247983, Example 4 | US9714236, 4 |
Type | Small organic molecule |
Emp. Form. | C26H32FN9O2 |
Mol. Mass. | 521.5898 |
SMILES | CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F |r| |
Structure |
|