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TargetTyrosine-protein kinase JAK1 [866-1154]
LigandBDBM264180
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
IC50 43.0±n/a nM
Citation Astrand, ABGrimster, NPKawatkar, SKettle, JGNilsson, MKRuston, LSu, QVasbinder, MWinter-Holt, JJWoessner, RDChuaqui, CEMcCabe, J Compounds and methods for inhibiting JAK US Patent US11247983 Publication Date 2/15/2022
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1 [866-1154]
Name:Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:Protein
Mol. Mass.:33185.74
Organism:Homo sapiens (Human)
Description:P23458[866-1154]
Residue:289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM264180
n/a
NameBDBM264180
Synonyms:(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H-indol- 7-yl)propanamide | US10167276, Example 4 | US10654835, Example 4 | US11247983, Example 4 | US9714236, 4
TypeSmall organic molecule
Emp. Form.C26H32FN9O2
Mol. Mass.521.5898
SMILESCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F |r|
Structure
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