Reaction Details |
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Target | Tyrosine-protein kinase JAK1 [866-1154] |
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Ligand | BDBM264238 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 17.0±n/a nM |
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Citation | Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US11247983 Publication Date 2/15/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK1 [866-1154] |
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Name: | Tyrosine-protein kinase JAK1 [866-1154] |
Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
Type: | Protein |
Mol. Mass.: | 33185.74 |
Organism: | Homo sapiens (Human) |
Description: | P23458[866-1154] |
Residue: | 289 |
Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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BDBM264238 |
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n/a |
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Name | BDBM264238 |
Synonyms: | (2R)-N-(3-{2-[(1- ethyl-3-methoxy-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide | US10167276, Example 58 | US10654835, Example 58 | US11247983, Example 58 | US9714236, 58 |
Type | Small organic molecule |
Emp. Form. | C27H35N9O2 |
Mol. Mass. | 517.6259 |
SMILES | CCn1cc(Nc2ncc(C)c(n2)-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)c(OC)n1 |r| |
Structure |
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