Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386893

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

290±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T; Tokunaga, N; Hirozane, M Substituted piperidine compound and use thereof US Patent US11292766 Publication Date 4/5/2022

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386893

n/a

Name

BDBM386893

Synonyms:

US10287305, Example 344 | US10508083, Example 344 | US11292766, Example 344 | methyl cis-2-(((cis-4-(4- methoxyphenyl)cyclohexyl)oxy)- methyl)-3- ((methylsulfonyl)amino)piperidine- 1-carboxylate

Type

Small organic molecule

Emp. Form.

C22H34N2O6S

Mol. Mass.

454.58

SMILES

COC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccc(OC)cc1 |r,wU:20.24,17.17,14.15,8.8,(,-4.23,;1.33,-3.46,;2.67,-4.23,;2.67,-5.77,;4,-3.47,;5.33,-4.24,;6.67,-3.47,;6.67,-1.93,;5.33,-1.15,;5.33,.39,;6.67,1.16,;8,.39,;5.9,2.49,;7.44,2.49,;4,-1.93,;2.67,-1.16,;2.67,.38,;1.33,1.15,;,.39,;-1.33,1.15,;-1.33,2.69,;,3.46,;1.33,2.69,;-2.67,3.46,;-2.67,5,;-4,5.77,;-5.33,5,;-6.67,5.77,;-8,5,;-5.33,3.46,;-4,2.69,)|

Structure