Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Ligand | BDBM445091 |
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Substrate/Competitor | n/a |
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Meas. Tech. | USP30 Biochemical IC50 Assay |
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IC50 | 550±n/a nM |
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Citation | Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent US11319287 Publication Date 5/3/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
Type: | PROTEIN |
Mol. Mass.: | 24819.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_974327 |
Residue: | 223 |
Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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BDBM445091 |
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n/a |
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Name | BDBM445091 |
Synonyms: | (S)-4,4-difluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile | US10669234, Example 30 | US11319287, Example 30 |
Type | Small organic molecule |
Emp. Form. | C18H17F2N5O |
Mol. Mass. | 357.3573 |
SMILES | Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N |
Structure |
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