Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 30 |
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Ligand | BDBM445203 |
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Substrate/Competitor | n/a |
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Meas. Tech. | UCHL1 Biochemical IC50 Assay |
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IC50 | <100±n/a nM |
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Citation | Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent US11319287 Publication Date 5/3/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 30 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 30 |
Synonyms: | Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30 |
Type: | Protein |
Mol. Mass.: | 58522.90 |
Organism: | Homo sapiens (Human) |
Description: | Q70CQ3 |
Residue: | 517 |
Sequence: | MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
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BDBM445203 |
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n/a |
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Name | BDBM445203 |
Synonyms: | (S)-1-cyano-N-(4-(6-cyano-3-ethoxypyridin-2-yl)thiazol-2-yl)-N-methylpyrrolidine-2-carboxamide | US10669234, Example 142 | US11319287, Example 142 |
Type | Small organic molecule |
Emp. Form. | C18H18N6O2S |
Mol. Mass. | 382.44 |
SMILES | CCOc1ccc(nc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N)C#N |r| |
Structure |
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