Reaction Details | |||
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Target | TGF-beta receptor type-1 | ||
Ligand | BDBM282899 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
IC50 | 0.500±n/a nM | ||
Citation | Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Dame, CP; Rahaman, H; Warrier, JS TGF-beta inhibitors US Patent US11352360 Publication Date 6/7/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
TGF-beta receptor type-1 | |||
Name: | TGF-beta receptor type-1 | ||
Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
Type: | enzyme | ||
Mol. Mass.: | 55968.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36897 | ||
Residue: | 503 | ||
Sequence: |
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BDBM282899 | |||
n/a | |||
Name | BDBM282899 | ||
Synonyms: | 6-(4-(3-chloro-4-fluorophenyl)-1-(3-fluorocyclobutyl)- 1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3- carbonitrile | US10287295, Example 104' | US11352360, Example 104' | US9884868, Example 104' | ||
Type | Small organic molecule | ||
Emp. Form. | C20H13ClF2N6 | ||
Mol. Mass. | 410.807 | ||
SMILES | FC1CC(C1)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 |(-2.83,-5.84,;-1.74,-4.75,;-1.74,-3.21,;-.2,-3.21,;-.2,-4.75,;.88,-2.12,;2.35,-2.6,;3.25,-1.35,;2.35,-.11,;.88,-.58,;-.45,.19,;-.45,1.73,;-1.78,2.5,;-3.12,1.73,;-4.58,2.2,;-5.49,.96,;-4.58,-.29,;-5.06,-1.75,;-5.53,-3.22,;-3.12,.19,;-1.78,-.58,;2.75,1.38,;1.66,2.47,;2.06,3.96,;3.54,4.35,;3.94,5.84,;4.63,3.27,;6.12,3.66,;4.24,1.78,)| | ||
Structure |