| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease HTRA1 |
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| Ligand | BDBM560246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRA1 Assay |
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| IC50 | 5.00±n/a nM |
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| Citation |  Gomez, R; Ding, J; Oballa, RM; Powell, DA; Epifanov, M Heterocyclic prolinamide derivatives US Patent US11377439 Publication Date 7/5/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease HTRA1 |
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| Name: | Serine protease HTRA1 |
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| Synonyms: | HTRA | HTRA1 | HTRA1_HUMAN | PRSS11 |
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| Type: | Protein |
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| Mol. Mass.: | 51293.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92743 |
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| Residue: | 480 |
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| Sequence: | MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
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| BDBM560246 |
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| n/a |
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| Name | BDBM560246 |
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| Synonyms: | US11377439, Example 83 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H50N8O8S2 |
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| Mol. Mass. | 786.961 |
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| SMILES | CC(C)(O)c1cnnn1[C@H]1C[C@H](N(C1)C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc(cc1)S(=O)(=O)NC1CC1)C(=O)NC1(CCSCC1)C(=O)C(N)=O |r| |
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| Structure | 
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