| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
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| Ligand | BDBM562377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Protein-Protein Interaction Assay |
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| IC50 | 0.940±n/a nM |
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| Citation |  Furst, L; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Wei, G; McCarren, PR; Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U; Nowak-Reppel, K Macrocyclic indole derivatives US Patent US11401278 Publication Date 8/2/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
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| Synonyms: | MCL-1/Noxa BH3 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329] |
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| Synonyms: | BCL2L3 | MCL1 | MCL1_HUMAN |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 17924.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[173-329] |
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| Residue: | 157 |
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| Sequence: | ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGML
RKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAE
SITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIR
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| Component 2 |
| Name: | Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
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| Synonyms: | APR_HUMAN | NOXA | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA)(BH3) |
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| Type: | n/a |
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| Mol. Mass.: | 2208.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13794[26-43] |
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| Residue: | 18 |
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| Sequence: | |
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| BDBM562377 |
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| n/a |
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| Name | BDBM562377 |
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| Synonyms: | (rac)-4-chloro-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,3,14-trimethyl-15-(rac)-[2-(morpholin-4-yl)ethyl]-11,12,14,15-tetrahydro-2H,10H-pyrazolo[3′,4′:4,5][1,2,8]thiadiazacycloundecino[6,7,8-hi]indole-8-carboxylic acid 13,13-dioxide (Mixture of Stereoisomers) | US11401278, Example 48 | US11401278, Example 65 | US11401278, Example 66 | US11401278, Example 67 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H43ClFN5O6S |
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| Mol. Mass. | 752.294 |
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| SMILES | CN1C(CCN2CCOCC2)c2nn(C)c(C)c2-c2c(Cl)ccc3c(CCCOc4cccc5cc(F)ccc45)c(C(O)=O)n(CCCS1(=O)=O)c23 |
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| Structure | 
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