Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
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Ligand | BDBM562401 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Protein-Protein Interaction Assay |
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IC50 | 1.10±n/a nM |
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Citation | Furst, L; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Wei, G; McCarren, PR; Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U; Nowak-Reppel, K Macrocyclic indole derivatives US Patent US11401278 Publication Date 8/2/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
Synonyms: | MCL-1/Noxa BH3 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329] |
Synonyms: | BCL2L3 | MCL1 | MCL1_HUMAN |
Type: | Membrane; Single-pass membrane protein |
Mol. Mass.: | 17924.29 |
Organism: | Homo sapiens (Human) |
Description: | Q07820[173-329] |
Residue: | 157 |
Sequence: | ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGML
RKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAE
SITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIR
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Component 2 |
Name: | Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] |
Synonyms: | APR_HUMAN | NOXA | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA)(BH3) |
Type: | n/a |
Mol. Mass.: | 2208.61 |
Organism: | Homo sapiens (Human) |
Description: | Q13794[26-43] |
Residue: | 18 |
Sequence: | |
BDBM562401 |
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n/a |
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Name | BDBM562401 |
Synonyms: | 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-15-[2-(morpholin-4-yl)ethyl]-13,13-dioxo-10,11,12,13,14,15-hexahydro-2H-13lambda6-pyrazolo[3',4':4,5][1,2,8]thiadiazacycloundecino[6,7,8-hi]indole-8-carboxylic acid (Mixture of Stereoisomers) | US11401278, Example 72 | US11401278, Example 73 | US11401278, Example 74 | US11401278, Example 75 | US11401278, Example 76 |
Type | Small organic molecule |
Emp. Form. | C39H45ClFN5O5S |
Mol. Mass. | 750.322 |
SMILES | CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)S(=O)CCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 |
Structure |
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