Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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Ligand | BDBM572199 |
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Substrate/Competitor | n/a |
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Meas. Tech. | MCL-1/Noxa BH3 Peptide (MCL-1 Assay) |
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IC50 | 0.870±n/a nM |
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Citation | Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Macrocyclic chlorine substituted indole derivatives US Patent US11447504 Publication Date 9/20/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
Synonyms: | MCL-1/Noxa BH3 Peptide |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 3 components. |
Component 1 |
Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321] |
Synonyms: | BCL2L3 | MCL1 | MCL1_HUMAN |
Type: | n/a |
Mol. Mass.: | 17056.39 |
Organism: | Homo sapiens (Human) |
Description: | Q07820[173-321] |
Residue: | 149 |
Sequence: | ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGML
RKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAE
SITDVLVRTKRDWLVKQRGWDGFVEFFHV
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Component 2 |
Name: | Maltose/maltodextrin import ATP-binding protein MalK |
Synonyms: | MALK_ECOLI | malK |
Type: | Protein |
Mol. Mass.: | 40990.98 |
Organism: | n/a |
Description: | P68187 |
Residue: | 371 |
Sequence: | MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDL
FIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEV
LQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLH
KRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMN
FLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVIL
EGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGT
ACRRLHKEPGV
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Component 3 |
Name: | Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V] |
Synonyms: | APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa |
Type: | Protein |
Mol. Mass.: | 3072.54 |
Organism: | Human |
Description: | Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide |
Residue: | 26 |
Sequence: | PAELEVEVATQLRRFGDKLNFRQKLL
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BDBM572199 |
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n/a |
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Name | BDBM572199 |
Synonyms: | (+)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic acid-N-ethylethanamine SaltEnantiomer 1 | US11447504, Example 52 |
Type | Small organic molecule |
Emp. Form. | C34H36ClN3O3 |
Mol. Mass. | 570.121 |
SMILES | CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C |
Structure |
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