| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 [1-211]/Bad BH3 Peptide |
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| Ligand | BDBM572219 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BCL-2/Bad BH3 Peptide (BCL-2 Assay) |
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| IC50 | 19000±n/a nM |
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| Citation |  Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Macrocyclic chlorine substituted indole derivatives US Patent US11447504 Publication Date 9/20/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 [1-211]/Bad BH3 Peptide |
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| Name: | Apoptosis regulator Bcl-2 [1-211]/Bad BH3 Peptide |
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| Synonyms: | BCL-2/Bad BH3 Peptide |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Apoptosis regulator Bcl-2 [1-211] |
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| Synonyms: | BCL2 | BCL2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 23308.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415[1-211] |
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| Residue: | 211 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFD
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| Component 2 |
| Name: | Bcl2-associated agonist of cell death [103-127,M117N] |
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| Synonyms: | BAD | BAD_HUMAN | BBC6 | BCL2L8 | cl2-associated agonist of cell death (BAD)(BH3) |
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| Type: | n/a |
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| Mol. Mass.: | 3088.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92934[103-127,M117N] |
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| Residue: | 25 |
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| Sequence: | NLWAAQRYGRELRRNSDEFVDSFKK
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| BDBM572219 |
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| n/a |
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| Name | BDBM572219 |
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| Synonyms: | (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,15-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid | US11447504, Example 74 | US11447504, Example 75 | US11447504, Example 76 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H34ClFN4O3 |
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| Mol. Mass. | 589.099 |
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| SMILES | CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 |
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| Structure | 
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