| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] |
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| Ligand | BDBM575641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition by Candidate Inhibitors (High) |
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| IC50 | <1±n/a nM |
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| Citation |  Sands, AT; Bence, NF; Zapf, CW; Cohen, F; Wang, C; Cummins, T; Tanaka, H; Shunatona, H; Cardozo, M; Weiss, D; Gosling, J 3-substituted piperidine compounds for Cbl-b inhibition, and use thereof US Patent US11464802 Publication Date 10/11/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] |
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| Name: | Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] |
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| Synonyms: | CBLB | CBLB_HUMAN | E3 ubiquitin-protein ligase CBL-B [36-427] | RNF56 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45487.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 36-427 (sequence in paper SEQ ID No: 1) |
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| Residue: | 392 |
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| Sequence: | PKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDN
QKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLA
EIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMA
LKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQK
YSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR
SYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTS
CLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
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| BDBM575641 |
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| n/a |
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| Name | BDBM575641 |
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| Synonyms: | US11464802, Compound 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27F5N6O2 |
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| Mol. Mass. | 586.5557 |
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| SMILES | Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C3)C#N)cc2C(F)(F)F)C1=O |r| |
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| Structure | 
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