Reaction Details |
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Target | Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] |
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Ligand | BDBM575676 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition by Candidate Inhibitors (Low) |
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IC50 | <1±n/a nM |
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Citation | Sands, AT; Bence, NF; Zapf, CW; Cohen, F; Wang, C; Cummins, T; Tanaka, H; Shunatona, H; Cardozo, M; Weiss, D; Gosling, J 3-substituted piperidine compounds for Cbl-b inhibition, and use thereof US Patent US11464802 Publication Date 10/11/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] |
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Name: | Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] |
Synonyms: | CBLB | CBLB_HUMAN | E3 ubiquitin-protein ligase CBL-B [36-427] | RNF56 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 45487.32 |
Organism: | Homo sapiens (Human) |
Description: | aa 36-427 (sequence in paper SEQ ID No: 1) |
Residue: | 392 |
Sequence: | PKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDN
QKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLA
EIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMA
LKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQK
YSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR
SYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTS
CLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
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BDBM575676 |
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n/a |
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Name | BDBM575676 |
Synonyms: | US11464802, Compound 39 |
Type | Small organic molecule |
Emp. Form. | C30H35F3N6O3 |
Mol. Mass. | 584.6325 |
SMILES | CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1 |r| |
Structure |
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